A chemometric and sensory study was conducted of ten Spanish red wines, all described as “Tempranillo Crianza 2010”, with Protected Designation of Origin (PDO). The analysis considered the following physicochemical parameters: alcohol content, SO2 level, acidity, tannin, antioxidant capacity and colour. In the chemometric study, Principal Component Analysis of the colour, Cluster Analysis, Analysis Of Variance (ANOVA) and the Kruskal-Wallis test showed that the samples corresponding to PDOs #8, #9 and #10 presented the highest number of differences from the rest. In the sensory analysis, Samples #9 and #10 were identified as the most different. From both types of study, we conclude that Samples #8, #9 and #10 present the greatest differences, while the remaining samples were very similar in their chemometric and sensory characteristics.