The combined use of seawater sea-sand concrete (SSC), epoxy-coated rebar (ECR) and fiber-reinforced polymer (FRP) can achieve significant economic and environmental benefits in coastal infrastructure constructions. Thus, this paper first presents an experimental and analytical study on the eccentric compression behavior of partially carbon FRP (CFRP) wrapped SSC columns reinforced with ECR. The effects of load eccentricities, thickness of CFRP strips, clear spacing ratios, and slenderness ratios were comprehensively analyzed. Test results show that as the eccentricity increased from 60 mm to 120 mm, the increment of load capacity of partially CFRP wrapped columns reduced by 27.6 % to 17.1 %. Moreover, a larger lateral deflection was detected for the specimens with a relatively high slenderness ratio, which results in an obvious second-order effect and further aggravates the nonlinearity of axial load-bending curves, especially for the specimens under a small eccentricity. In addition, an eccentricity-dependent stress-strain model for concrete was developed under FRP strip-steel hoop composite confinement, and the lateral deflection formula of eccentrically loaded columns was also derived based on force equilibrium analysis. Finally, a new theoretical formula incorporating the effect of the slenderness ratio was also presented for the determination of load and moment capacity of the partially CFRP wrapped columns based on section analysis. By comparing with the test results, the developed model exhibits satisfactory accuracy.