Large-scale structures are often built using space frames or trusses. These can become complex if the geometry of the space frame structure is customizable and if they do not contain any recurring components. Consequently, the design effort required, and the production cost of these unique components become large. Further, designing and creating these structures is challenging for novice designers as these processes require large design know-how. This challenge can be addressed with a knowledge-based engineering (KBE) approach. Design processes for specific, repeating tasks are analyzed and broken down into individual steps, which can be automated as a rule-based design procedure.This work introduces an automated design workflow that follows a KBE approach. The workflow automates the design process for irregular space frame structures. The workflow takes a mesh geometry of the space-frame structure as an input, and decomposes the mesh to nodes, bars, and panels. The workflow then generates and exports the fabrication data that are required for production: STL files for the three-dimensional node geometries that are additively manufactured with multi jet fusion, cutting lines for the planar panels that are produced with a laser-cuter, and length values that are used to cut straight bars. The work describes in detail the rules applied for the automation of the design process. This automated design workflow enables novice designers to create space frame structures with reduced design effort. The workflow is applied on a horse sculpture to demonstrate the manufacturability of the parts and the assembly of the space frame structure.