In this paper, we investigate a novel implication of the non-negligible spacetime curvature at large distances when its effects are expressed in terms of a suitably modified form of the Heisenberg uncertainty relations. Specifically, we establish a one-to-one correspondence between this modified uncertainty principle and the Standard Model Extension (SME), a string-theoretical effective field theory that accounts for both explicit and spontaneous breaking of Lorentz symmetry. This tight correspondence between string-derived effective field theory and modified quantum mechanics with extended uncertainty relations is validated by comparing the predictions concerning a deformed Hawking temperature derived from the two models. Moreover, starting from the experimental bounds on the gravity sector of the SME, we derive the most stringent constraint achieved so far on the value of the free parameter in the extended Heisenberg uncertainty principle.