Addresses the challenges and considerations of criminalistics and crime scene investigation in extraterrestrial gravitational environments. Future space exploration may require the development of protocols for extraterrestrial crime scene investigations. Challenges in microgravity effects, confined space environments, forensic techniques, communication, coordination, and legal jurisdiction are highlighted in this brief. Microgravity effects create difficulties in dis-placing evidence, such as blood spatter patterns, which make interpretation of events difficult. Restricted areas such as spacecraft and stations require special techniques and equipment. Storing and securing evidence in microgravity makes traditional methods impractical. The lack of gravity affects fingerprint development and preservation, requiring the use of alternative methods. Compact and specialized equipment is required to analyze DNA in space. Communication de-lays hinder real-time collaboration between researchers on Earth and those in space. Guidance can be provided to personnel in space with remote technologies and autonomous systems. Determining legal jurisdiction for crimes committed in space or on spacecraft requires complex international cooperation and agreements. The development of space law, technology and international agreements is important to meet the challenges of extraterrestrial crime scene investigations. Future discussions and research will provide a basis for establishing protocols for extraterrestrial crime scene investigations to ensure effective and fair forensic practices. As space exploration progresses, advances need to be made in these areas. As space exploration advances, the development of space law, technology, and international agreements is crucial to meeting the unique challenges of extraterrestrial crime scene investigations. This summary provides a basis for future discussions and research regarding the establishment of protocols to ensure effective and fair forensic practices off Earth.