We report paleomagnetic and rock magnetic data from the rapakivi granites of the Parguaza batholith (Guyana Precambrian Shield, southwestern Venezuela). These results suggest that the pluton is inversely zoned with respect to the cooling ages. In order to explain such an age pattern, tentative structural settings are proposed placing the Parguaza intrusions in a plate tectonic context. Six sites were sampled along a 200 km transect that cuts through the northern lobe of the batholith. Thermomagnetic curves, X-ray diffraction and fluorescence, hysteresis loops, thermal and alternating field (AF) intensity plots, transmission (TEM) and scanning (SEM) electron microscope analyses and Königsberger ratios (Qn) values were used to identify the different magnetic mineralogies and their distribution of grain sizes. Magnetite, titanomagnetite near magnetite in composition and deuteric hematite are the three carriers of natural remanent magnetizations (NRMs) in these rocks. Magnetic granulometry indicators such as Königsberger ratios (Qn values) suggest the dominant presence of single domain magnetites with average grain sizes grading from finer to coarser away from the center of the transect. The paleomagnetic results reveal the existence of two primary thermoremanent and/or thermochemical magnetizations (TRMsTCRMs) for sites CSP-3, PI-2 and PI-4 (Decl. = 328°, Incl. = −21°, k = 15, α95 = 11.4°) and site CSP-2, PI-1 and PI-3 (Decl. = 16°, Incl. = 87°, k = 10, α95 = 13°), respectively. There is also a poorly defined G3R2 magnetization (Decl. = 284°, Incl. = −86°, k = 6, α95 = 27°) found in sites CSP-2, PI-1 and PI-3. The overlap of coercivities and the unblocking temperatures spectra, probably resulting from the coexistence of primary single-domain magnetic mineralogies with secondary exsolutions of single-domain-like Ti-poor (Fe-rich) regions (almost pure magnetite) in multidomain titanomagnetite grains, in most cases precludes the complete resolution of hybrid G1 (N + R) or G3 (N + R). The relative ages for these components were determined using a map of RbSr model age ‘chrontours’. G1 and G3 are the older and the younger TRMsTCRMs, respectively, and were acquired at two discrete moments of the batholith's geological history. The final map resulting from integrating the paleomagnetic and RbSr data, shows an age pattern for this batholith, and the rest of the intrusions that belong to the Parguaza Igneous Complex, that could be explained either as the effect of inverse cooling of a single intrusive body, the sequential emplacement of magmas controlled by normal faulting or an internal tectonism resulting in a system of NE-trending horsts and grabens cutting through the pluton. Because of its feasibility and agreement with the most recent theories about the tectonic evolution of the Guyana Shield, we favor the latter hypothesis.