The object of the study is cultural genesis in the Southern Urals in the Late Middle Ages and Modern Times. The subject of the study is the factors influencing its development, which are considered through the prism of studying the archaeological material obtained during reconnaissance work on the monuments of the XVI – early XX centuries. This problem was not the object of special study. At the same time, its solution, on the one hand, fills in the gaps in the analysis of the processes of cultural genesis in the region as a whole, and on the other hand, contributes to the study of the peculiarities of the ethnocultural development of individual ethnic groups living here in the past. The theoretical basis of the research is the researches of Russian scientists in the field of cultural genesis, containing conceptual and theoretical developments. The information base of the study was the factual material on the problem under study, obtained during archaeological research on the territory of the Republic of Bashkortostan, including by the author himself, interdisciplinary and systematic approaches were used in the work for a comprehensive analysis of the designated problem, theoretical modeling, generalization, comparative historical, comparative typological methods were also used in the work. The scientific novelty of the study is due to the fact that for the first time the factors of cultural development in the Southern Urals in the Late Middle Ages and Modern Times were systematized and analyzed, which were considered in the context of the archaeological direction of cultural genesis research. It was revealed that the development of culture in the Southern Urals in the XVI – early XX centuries was influenced by both external (natural-geographical, anthropogenic, colonization, etc.) and internal (ethnic, religious, etc.) factors, which are recorded to varying degrees by the cultural layers of urban and rural settlements, fortifications and factories, cemeteries , etc. At the same time, speaking about the factors of cultural genesis, it should be borne in mind that they are so closely interrelated that it is often difficult to determine whether a change in culture is the result of the influence of one or another factor or several at the same time.