Abstract The Modeling Eddies in the Southern Ocean (MESO) project uses numerical sensitivity studies to examine the role played by Southern Ocean winds and eddies in determining the density structure of the global ocean and the magnitude and structure of the global overturning circulation. A hemispheric isopycnal-coordinate ocean model (which avoids numerical diapycnal diffusion) with realistic geometry is run with idealized forcing at a range of resolutions from coarse (2°) to eddy-permitting (1/6°). A comparison of coarse resolutions with fine resolutions indicates that explicit eddies affect both the structure of the overturning and the response of the overturning to wind stress changes. While the presence of resolved eddies does not greatly affect the prevailing qualitative picture of the ocean circulation, it alters the overturning cells involving the Southern Ocean transformation of dense deep waters and light waters of subtropical origin into intermediate waters. With resolved eddies, the surface-to-intermediate water cell extends farther southward by hundreds of kilometers and the deep-to-intermediate cell draws on comparatively lighter deep waters. The overturning response to changes in the winds is also sensitive to the presence of eddies. In noneddying simulations, changing the Ekman transport produces comparable changes in the overturning, much of it involving transformation of deep waters and resembling the mean circulation. In the eddy-permitting simulations, a significant fraction of the Ekman transport changes are compensated by eddy-induced transport drawing from lighter waters than does the mean overturning. This significant difference calls into question the ability of coarse-resolution ocean models to accurately capture the impact of changes in the Southern Ocean on the global ocean circulation.