The wetlands of the southern Louisiana coast are disappearing due to a host of environmental stressors. Thus, it is imperative to analyze the spatial and temporal variability of wetland vertical accretion rates. A key question in accretion concerns the role of landfalling hurricanes as a land-building agent, due to their propensity to deposit significant volumes of inorganic sediments. Since 1996, thousands of accretion measurements have been made at 390 sites across coastal Louisiana as a result of a regional monitoring network, called the Coastal Reference Monitoring System (CRMS). We utilized this dataset to analyze the spatial and temporal patterns of accretion by mapping rates during time periods before, around, and after the landfall of Hurricane Isaac (2012). This analysis is vital for quantifying the role of hurricanes as a land-building agent and for understanding the main mechanism causing heightened wetland accretion. The results show that accretion rates averaged about 2.89 cm/year from stations sampled before Isaac, 4.04 cm/year during the period encompassing Isaac, and 2.38 cm/year from sites established and sampled after Isaac. Accretion rates attributable to Isaac’s effects were therefore 40% and 70% greater than before and after the event, respectively, indicating the event’s importance toward coastal land-building. Accretion associated with Isaac was highest at sites located 70 kilometers from the storm track, particularly those near the Mississippi River and its adjacent distributaries and lakes. This spatial pattern of elevated accretion rates indicates that freshwater flooding from fluvial channels, rather than storm surge from the sea per se, is the main mechanism responsible for increased wetland accretion. This significance of riverine flooding has implications toward future coastal restoration policies and practices.