Abstract Lightning around the world poses a significant threat to life, infrastructure, and economic sectors. This study evaluates lightning risk at the municipal level in Mexico, recognizing the interplay of hazard and vulnerability in risk estimation. Despite declining lightning-related fatalities, possibly attributed to demographic shifts and improved urban infrastructure, persistent social vulnerability exists, particularly among rural populations engaged in labor-intensive agriculture with lower education levels. We estimate a risk map for lightning-related fatality risk in Mexico, where we identify high-risk regions along the Sierra Madre Occidental, the Pacific coast, and central and southeastern Mexico, marked by elevated lightning days and social vulnerability. The risk map integrates hazard and social vulnerability, capturing the distribution of fatality incidents, and it reveals that 82.1% of incidents occurred in municipalities categorized as “high” or “very high” risk. This result emphasizes the need to consider both physical hazard and social vulnerability for a comprehensive assessment of lightning risk. This study contributes to understanding lightning risk in Mexico, providing crucial insights at the municipality level for informing policymaking and targeting risk mitigation strategies. By highlighting the interrelation of hazard and social vulnerability, this research aligns with broader goals of enhancing local resilience and safety in the face of natural hazards, highlighting the ongoing need for disaster risk reduction efforts. Significance Statement This study provides a comprehensive evaluation of the risk of death by lightning at the municipality level in Mexico, considering the intricate interplay between hazard and social vulnerability. By analyzing both the physical hazard of lightning and the social vulnerability of exposed populations, the study provides a map estimating the risk level for each municipality. The risk map, capturing the interrelation of hazard and vulnerability, provides a powerful tool for policymakers and emergency responders. With 82.1% of lightning fatalities concentrated in municipalities with “high” and “very high” risk, this work underscores the need for comprehensive risk assessment strategies. This research contributes knowledge for informed decision-making, targeted interventions, and the ongoing pursuit of enhancing community resilience to lightning-related hazards.