The rapidly changing digital landscape presents a new context highlighting growth strategies and organizational ambidexterity. This research explores the interaction between growth strategies of rural SMEs, digital orientation, and organizational ambidexterity during the COVID-19 pandemic. The survey data comprised 204 responses from Finnish SME owner-managers in the rural region of South Ostrobothnia in October 2021. The results from the ordinal regression analysis demonstrate that organizational ambidexterity positively influences the utilization of all growth strategies, serving as a mediator in the relationship between digital orientation and these strategies. Digital orientation is positively associated with applying a product/service development strategy, market development strategy, diversification, and business model development but not with market penetration strategy. These findings suggest that a digital orientation enables SMEs to strike a balance between exploration and exploitation, allowing them to effectively pursue both. Furthermore, digitalization offers rural businesses opportunities to implement more demanding growth strategies. Therefore, to ensure the long-term vitality of rural areas, society and policymakers must collaborate in providing robust digital infrastructure.