South Brazil Research Articles

Rethinking rectal cancer management through COVID: Real word evidence in a public hospital in the south of Brazil.

e15620 Background: Treatment of locally advanced rectal cancer is based on a combination of radiotherapy and chemotherapy, either as adjuvant, neoadjuvant or total strategies. Short course radiotherapy followed by neoadjuvant chemotherapy, as described in the RAPIDO trial, was chosen by our Oncology, Radiotherapy and Coloproctological tumor board at Hospital de Clínicas de Porto Alegre during the COVID19 pandemic as a measure to reduce hospital visits and thus the possibility of transmission and infection by the SARS-COV-2 virus. Methods: We performed an observational analysis, including all patients treated with short course radiotherapy for locally advanced rectal cancer, at the Hospital de Clínicas de Porto Alegre in the period between January 2020 and March 2023. Metastatic patients were included, either treated with curative or palliative intent. Demographic characteristics, clinical staging, timing of chemotherapy, radiotherapy and surgery were analyzed. Clinical response was evaluated through sigmoidoscopy and clinical rectal exam. Patients with complete clinical response were offered the watch and wait strategy or surgery, after careful discussion of the possible benefits and risks. Results: Ninety-six patients were submitted to short course radiotherapy in the period described. Seven (7) patients were excluded; 89 patients were included in the final analysis. Fifty-five percent were male; mean age was 62 ±12.5 years; 52.8% were ECOG 1 at the diagnosis. Median CEA value at diagnosis was 7 ng/mL (CI 95%:4.4 - 9.8). Sixty-four percent were stage III, 31.4% stage IV, 3.3% stage II. Ninety-eight percent completed the programmed radiotherapy treatment. Only two patients received less than 25Gy. Forty-nine percent of patients completed the whole planned chemotherapy treatment; 15.7% were treated with palliative intent chemotherapy and 5.6% couldn’t receive chemotherapy for other reasons. Clinical response data were available in 62 patients: the main reason for unavailable clinical response was metastatic disease. Disease control was achieved in 98.4% of the cases, with only 1 patient having progressive disease during treatment (1.6%). The overall clinical response rate was 72.6%, 25.8% had stable disease and 24.2% complete clinical response. Fifteen of the 16 patients that presented with complete clinical response opted into a watch and wait strategy, achieving a 1-year disease free survival of 86.6%. Conclusions: Adopting the RAPIDO approach had a positive outcome in our advanced rectal cancer population. Short course radiotherapy followed by chemotherapy achieved excellent rates of disease control. Almost 25% of the non-metastatic patients undergoing RAPIDO treatment achieved complete clinical response opting into a watch and wait program.

The Impact of Mega Sports Events on the Strength of the National Soft Power: A Comparative Analysis

Abstract This article examines the strategic use of mega sports events as a means to enhance national soft power, exploring the complex interplay between international sports diplomacy and geopolitical influence. The study will examine how these events serve as means of economic and cultural diplomacy and also as platforms for global interaction through a comparative analysis of countries that include South Africa, Brazil, Russia, Germany, and Qatar. Employing a qualitative methodology, the research synthesizes the existing literature and case studies to provide information on the objectives, strategies, and outcomes associated with hosting such events. This study aims to contribute to the larger discussion on soft power and its effectiveness in the modern international arena by analyzing the complex effects of these mega events on national branding. It does this by providing a nuanced understanding of how major international sporting events can affect geopolitical dynamics and shape international perceptions.

THE SETAs AND S-SYSTEM SKILLS DEVELOPMENT IN SOUTH AFRICA AND BRAZIL: A TRANSFORMATIVE SOCIAL POLICY PERSPECTIVE

Relevance. The African Union declared 2024 the Year of Education, Educating an African Fit for the 21st Century and the Agenda 2063 aspiration seeks to catalyse an education and skills revolution for Africa’s industrialisation. This places Technical and Vocational Education and Training at the centre in skills development on the continent. As part of their endogenous initiatives at improving skills, knowledge and abilities desired for work and enhance industrial competitiveness South Africa and Brazil instituted the SETAs system and the S-System, respectively aimed at skills formation and human capital development. Aim. The two BRICS countries of South Africa and Brazil, through Acts of Parliament, institutionalised skills development programs which had seen them emerge as leading economies on their respective continents. What key lessons can be drawn for other African countries in their quest for industrialisation in the AU Year of the Year of Education to foster the relevant and competitive skills needed for the 21st century. Methods. The case studies of the S-system of Brazil and the SETAs system of South Africa are presented using a case study approach. Examining the SETAs and S-systems using a Transformative Social Policy framework, the paper adopts a case study approach seeks to answer the following questions: (1) what kind of institutional linkages and coordination between industry/business and skills/education training institutions need to be in place for adequate and appropriate human capital formation in Africa? (2) what are the appropriate funding mechanisms for human capital development suitable for African countries to adopt? (3) What coordination and facilitating role should be adopted by states in African countries to facilitate industry/training institutional linkages? Results and conclusions. Key finding indicates that while the SETAs in South Africa are widely recognised by employers and give holders a big advantage in securing employment, TVET-market coordination, regional coordination for area-specific industrialisation and appropriate skills funding mechanism are key for competitive skills development and provide practical and policy lessons for African governments.

Decolonizing Through Public History – Introduction

Abstract Decolonization is the subject of an abundant literature, both as a historical event and as a contemporary process. In relations with the past, debates have risen about issues such as colonial monuments, museum collections, and repatriation. Rather than dealing with a specific type of space, institution, or material, this special issue in International Public History offers a discussion on the many links between decolonization and public history. The articles explore if and to what extent public history practices can contribute to decolonizing the history production process (through decolonized sources, decolonized interpretation processes, and decolonized space of communication of history). The articles discuss what ‘public’ in ‘public history’ means: who is doing history, for whom, with whom, and for what? The self-reflective approach of public history also questions the colonial bias and processes at stake in institutions such as archives, museums, and universities. The special issue includes contributions from various countries (South Africa, Kenya, Brazil, Canada, and Japan) to foster discussions on the plurality of links between public history and decolonization in an international context that goes beyond the too-often Western oriented public history frameworks.

Scientific Mapping of Elderly Food Studies: A Bibliometric Approach

As the global population ages, there is a growing emphasis on addressing the dietary needs and overall well-being of older individuals. Bibliometric analysis of existing literature on food innovation for the elderly helps identify research trends and gaps, guiding future exploration to better meet the nutritional needs and preferences of this population. The aim of this research is to examine the literature on food and nutrition for older adults through bibliometric analysis. Data was gathered on April 19th, 2024, from the Scopus database by using the search term "elder* AND food". Articles were restricted to specific subject areas and then analyzed using VOSviewer and descriptive statistics. A total of 746 articles published between 1951 and 2024 were discovered, with a notable rise in publications in the past decade. The United States ranked first in the number of published articles, followed by South Korea and Brazil. Keywords were grouped into 11 clusters, encompassing themes such as diet quality, food security, nutritional status, and elderly care. The analysis underscored the global importance of research on elderly nutrition, underscoring the necessity for international cooperation. Recent developments revealed a concentration on food-based dietary guidelines and the management of food bolus for older individuals. The study also addressed limitations, such as potential biases arising from relying on Scopus and excluding non-English publications.

Feasibility of using in situ UV/Vis spectrometer probe for measuring COD in WWTP based on UASB reactor

The aim of this work is to report the use of a UV/Vis spectrometer for real time, in situ monitoring of the chemical oxygen demand (COD) in a municipal wastewater treatment plant (WWTP) operating with upflow anaerobic sludge blanket (UASB) reactor, installed in south of Brazil. The spectrometer was used according to the factory calibration procedures: global, local offset and local linear. COD probe measurements were compared to laboratory analyses for the calibration procedures. Continuous operation led to increasing errors, which was related to grime deposition on the probe window and avoided with periodic cleaning. Performance of the probe measurements versus laboratory analyses was evaluated with coefficient of determination, root mean squared error (RMSE), relative RMSE, RMSE to standard deviation ratio (RSR) and Student’s t-test. It is concluded that the best calibration procedures is the local linear, for the influent and the effluent of UASB reactor. The probe consists of an improvement to real time and in situ monitoring of South America WWTPs.

The Brazilian Hymnological Melting Pot: Investigating Ethnoracial Discourses in the Compilation of the Lutheran Hymnal Livro de Canto (2017)

In 1926, a New York Times article described the cultural and ethnic flows in south Brazil as a “Melting Pot”. The report predicted that German Brazilians, tied to their ethnoracial origin, would soon be Brazilianized. The study of congregational song practices offers insight into the relationship between migration, race, culture, and ethnicity. Moreover, investigating Brazilian Lutheran singing practices helps us understand how the New York Times’ prediction unfolded on the ground. This paper examines the Brazilian Lutheran hymnal Livro de Canto, published in 2017, and displays how Brazil’s ethnoracial diversity is manifested and negotiated in the Lutheran context, both musically and theologically. By interviewing members of the hymnal committee and investigating how they dealt with Brazil’s ethnoraciality in the context of the hymnal compilation, this paper demonstrates ways denominations and churchgoers negotiate theological, cultural, musical, and ethnoracial identities through congregational singing. More importantly, it showcases how Brazilian Lutheran church music practices inform broader social conversations around racism, nationalism, Blackness, and Brazilianness.

Genotoxicity detected during cyanobacteria bloom in a water supply reservoir

The aquatic ecosystems are susceptible to cyanobacterial blooms due to the eutrophication of water bodies caused by human activities. In this study, phytoplankton and cyanotoxins analysis, as well as cellular and genetic biomarkers of toxicity (Allium cepa test - higher plant test system), were evaluated in water samples of Alagados Reservoir during a cyanobacterial bloom in South Brazil. The water samples were collected during the wet season at two sites in the Reservoir. Paralytic shellfish toxins (PSTs) were detected in both samples (sites 1 and 2); however, the levels of PSTs were higher in site 1. Gonyautoxin 2 was the major cyanotoxin found in the Reservoir. Both samples were able to induce cytotoxic effects (reduced Mitotic Index) and damage the genetic material (i.e., increased frequencies of chromosome aberration and micronuclei) of meristematic cells of A. cepa. The cellular and genetic damages were higher in the sample site 1, wherein high levels of PSTs were verified. Thus, our findings suggested that cyanotoxins-contaminated waters may damage the genetic material of living organisms, and therefore this group of contaminants should be assessed for their potential genotoxicity.

Exercise as medicine! Physical activity mitigated the impact of the COVID-19 pandemic on depressive symptoms in adults with depression

We investigated the longitudinal association between physical activity (PA) and symptoms of depression and anxiety in people with depression during the COVID-19 pandemic. We used data from baseline (June 2020) to wave 3 (June 2021) of the PAMPA Cohort, an ambispective cohort with adults in south Brazil. The Hospital Anxiety and Depression Scale assessed depressive and anxiety symptoms in all waves. Participants reported frequency (minutes), type (aerobic, strength, combined), and place (out of home, at home) of physical activity at baseline. Generalized linear models were used to investigate the interaction between time and PA, adjusting for possible confounding variables. Subjective memory decline was assessed using multivariate Cox proportional hazard regression models to obtain adjusted hazard ratio (HR) and respective 95% confidence interval (CI). Participants (n = 424) with self-reported clinically diagnosed depression were included. We observed a non-linear increase trajectory of depression during the first year of the COVID-19 pandemic. PA was associated with a slower trajectory of depressive (slope: −1.89; 95%CI: −3.34, −0.43 points) but not anxiety (slope: −1.33; 95%CI: −2.93, 0.25 points) symptoms during the COVID-19 pandemic. Participants who continued physically active from pre-pandemic in wave 1 showed a lower risk of subjective memory decline during follow-up than those who persisted inactive in the same period (HR: 0.52; 95%CI: 0.30, 0.89). PA attenuated the impact of the COVID-19 pandemic on depressive symptoms in adults living with depression in south Brazil. Regularity of physical activity was associated with fewer depression and anxiety symptoms and a lower risk of subjective memory decline.

Baseline and end-of-treatment host serum biomarkers predict relapse in adults with pulmonary tuberculosis

There is a need for new tools for monitoring of the response to TB treatment. Such tools may allow for tailored treatment regimens, and stratify patients initiating TB treatment into different risk groups. We evaluated combinations between previously published host biomarkers and new candidates, as tools for monitoring TB treatment response, and prediction of relapse. Serum samples were collected at multiple time points, from patients initiating TB treatment at research sites situated in South Africa (ActionTB study), Brazil and Uganda (TBRU study). Using a multiplex immunoassay platform, we evaluated the concentrations of selected host inflammatory biomarkers in sera obtained from clinically cured patients with and without subsequent relapse within 2 years of TB treatment completion. A total of 130 TB patients, 30 (23%) of whom had confirmed relapse were included in the study. The median time to relapse was 9.7 months in the ActionTB study (n=12 patients who relapsed), and 5 months (n=18 patients who relapsed) in the TBRU study. Serum concentrations of several host biomarkers changed during TB treatment with IL-6, IP-10, IL-22 and complement C3 showing potential individually, in predicting relapse. A six-marker signature comprising of TTP, BMI, sICAM-1, IL-22, IL-1β and complement C3, predicted relapse, prior to the onset of TB treatment with 89% sensitivity and 94% specificity. Furthermore, a 3-marker signature (Apo-CIII, IP-10 and sIL-6R) predicted relapse in samples collected at the end of TB treatment with sensitivity of 71% and specificity of 74%. A previously identified baseline relapse prediction signature (TTP, BMI, TNF-β, sIL-6R, IL-12p40 and IP-10) also showed potential in the current study. Serum host inflammatory biomarkers may be useful in predicting relapse in TB patients prior to the initiation of treatment. Our findings have implications for tailored patient management and require prospective evaluation in larger studies.

ORGANIZACIONES SOSTENIBLES? LA PERCEPCIÓN DE LOS ESTUDIANTES DE UNA INSTITUCIÓN DE EDUCACIÓN SUPERIOR

The role of Higher Education Institutions (HEIs) as opinion and behavior makers has long been recognized and this affects relevant issues between society and organizations such as sustainability. Studying how university students perceive sustainability in organizations can reveal guidelines for decision-making and actions in HEIs. There fore, the objective of this study is to verify which factors and variables impact the perception of students about the sustainability of organizations. A Survey was conducted with students of an HEI in south of Brazil. Data collection was performed through a questionnaire and a valid sample of 895 respondents was obtained. The results show the positive impact of the factors Environmental and Sustainable Aspects, Social, Ethical and Corporate Governance. It is concluded that the elements that form these factors generate guidelines for theim provement of sustainability practices.

Effects of different production systems on health, zootechnical and metabolic parameters in Holstein calves in the extreme south of Brazil

The aim of this study was to evaluate the incidence of diseases as well as metabolic and zootechnical parameters in Holstein calves maintained in individual or collective housing systems in the extreme south of Brazil. One hundred calves were included immediately after birth and monitored for 90 days. Animals were randomly divided into two groups: individual stalls group (ISG; n=50) and collective stalls group (CSG; n=50). ISG calves were individually housed in 1.2m² wood pens and received 6 L of milk/day and concentrate food and water ad libitum for 90 days. Calves in the CSG were housed in groups of up to 25 animals, in a total of two stalls containing one animal per 3 m2. CSG calves received up to 8 L of milk/day at 0-15 days, milk ad libitum at 15-40 days, 7.2 L of milk. /day at 40-60 days, and gradual weaning at 60-90 days with concentrate food and water ad libitum, using an automatic feeder. In both groups, Zootechnical parameters (weight, thoracic perimeter, height at the withers, and rump width) were measured weekly during the first 28 days and once every 15 days until weaning. Blood samples were retrieved weekly during the first 28 days. Metabolic parameters evaluated in this study were total calcium, beta-hydroxybutyrate (BHBA), free fatty acids (FFA), and glucose. The animals were monitored daily for clinical signs of diseases diarrhea and respiratory symptoms. General morbidity was higher in CSG 92% compared to ISG 74% (p<0.05). We observed increased diarrhea-related morbidity and a higher rate of recurrence in the ISG (50% and 60%, respectively; p<0.05) compared to those in the CSG (both 20%, p<0.05 between groups). The morbidity due to bronchopneumonia was higher in the CSG (92%) than in the ISG (74%, p<0.05). Recurrence of bronchopneumonia and mortality were similar between groups (p>0.05). Glucose, FFA, and BHBA concentrations were higher in the ISG (p<0.05) and total calcium higher in CSG (p<0.05). Finally, the weight and thoracic perimeter were higher in the CSG than those in the ISG, whereas the height and, rump width, at the withers was higher in the ISG than that in the CSG (p<0.05). In conclusion, animals raised in a collective system with automatic feeders exhibited less diarrhea and increased serum calcium as well as improved zootechnical development, although they had a higher incidence of bronchopneumonia.

Four Storm Surge Cases on the Coast of São Paulo, Brazil: Weather Analyses and High-Resolution Forecasts

The coast of São Paulo, Brazil, is exposed to storm surges that can cause damage and floods. These storm surges are produced by slowly traveling cyclone–anticyclone systems. The motivation behind this work was the need to evaluate high-resolution forecasts of the mean sea-level pressure and 10 m winds, which are the major drivers of the wave model. This work is part of the activity in devising an early warning system for São Paulo coastal storm surges. For the evaluation, four case studies that had a major impact on the coast of São Paulo in 2020 were selected. Because storm surges that reach the coast may cause coastal flooding, precipitation forecasts were also evaluated. The mesoscale Eta model produces forecasts with a 5 km resolution for up to an 84 h lead time. The model was set up in a region that covers part of southeast and south Brazil. The ERA5 reanalysis was used to describe the large-scale synoptic conditions and to evaluate the weather forecasts. The cases showed a region in common between 35° S, 40° S and 35° W, 45° W where the low-pressure center deepened rapidly on the day before the highest waves reached the coast of São Paulo, with a mostly eastward, rather than northeastward, displacement of the associated surface cyclone and minimal or no tilt with height. The winds on the coast were the strongest on the day before the surge reached the coast of São Paulo, and then the winds weakened on the day of the maximum wave height. The pattern of the mean sea-level pressure and 10 m wind in the 36 h, 60 h, and 84 h forecasts agreed with the ERA5 reanalysis, but the pressure was slightly underestimated. In contrast, the winds along the coast were slightly overestimated. The 24 h accumulated precipitation pattern was also captured by the forecast, but was overestimated, especially at high precipitation rates. The 36 h forecasts showed the smallest error, but the growth in the error for longer lead times was small, which made the 84 h forecasts useful for driving wave models and other local applications, such as an early warning system.

Contribution of Syphilis to Adverse Pregnancy Outcomes in People Living With and Without HIV in South Brazil: 2008 to 2018.

Syphilis coinfection among pregnant people living with HIV (PLH) may worsen pregnancy outcomes. We evaluated the impact of syphilis coinfection on pregnancies in south Brazil. Data were extracted from hospital records between January 1, 2008, and December 31, 2018. Preterm birth (PTB), low birth weight (LBW <2500 g), and a composite adverse infant outcome (AIO: HIV vertical transmission, loss to follow-up before HIV diagnosis, stillbirth, congenital syphilis) were evaluated among pregnancies without HIV and syphilis (PWOH + S), PLH monoinfection, syphilis monoinfection (PLS), and PLH with syphilis (PLH + S). Among 48,685 deliveries where patients were tested for HIV and syphilis, 1353 (2.8%) occurred in PLH; of these, 181 (13.4%) were HIV/syphilis coinfected (PLH + S). Among PLH, 2.4% of infants acquired HIV and 13.1% were lost to follow-up before HIV diagnosis. Among all PLS, 70.5% of infants acquired congenital syphilis. Across the cohort, 1.2% stillbirths/neonatal deaths occurred. Thirty-seven percent of PLH + S did not initiate antiretroviral therapy versus 15.4% of PLH monoinfection ( P < 0.001). Less than half (37.6%) of PLH + S had VDRL titers ≥1:16 compared with 21.7% of PLS only ( P < 0.001). Among PLH, syphilis coinfection and unknown/high VDRL titers (≥1:16) increased AIO risk more (adjusted relative risk [aRR], 3.96; 95% confidence interval [CI], 3.33-4.70) compared with low VDRL titers (≤1:8; aRR, 3.51; 95% CI, 2.90-4.25). Unsuppressed viremia (≥50 copies/mL) was associated with risk of PTB (aRR, 1.43; 95% CI, 1.07-1.92) and AIO (aRR, 1.38; 95% CI, 1.11-1.70) but not LBW. Lack of prenatal care was significant in predicting PTB and LBW in all PLH and PLS monoinfection. Syphilis coinfection worsens AIOs in all women and compounds negative effects of HIV infection during pregnancy. Effective syphilis treatment and HIV viral load suppression are paramount for optimal obstetric care.

Abstract PO5-02-14: Clinical-pathological determinant factors to choose between four or six cycles of adjuvant chemotherapy with docetaxel/cyclophosphamide (TC) in a retrospective real-world cohort of HER2-negative breast cancer patients

Abstract Introduction: The long-term severe adverse events associated with anthracyclines, including irreversible cardiotoxicity, myelodysplastic syndromes, and therapy-related leukemias, led researchers to question the risk-benefit of anthracycline-based chemotherapy regimens, especially for patients without axillary lymph node involvement, leading to an increasing trend to omit anthracyclines in adjuvant treatment. Docetaxel plus cyclophosphamide (TC) has replaced doxorubicin plus cyclophosphamide (AC) for lower-risk patients that need adjuvant chemotherapy. However, the optimal number of cycles of adjuvant in patients with node-positive or node-negative breast cancer is currently unknown. Methods: We performed a retrospective cohort study of patients with HER2-negative breast cancer, stage I to III, that received adjuvant docetaxel and cyclophosphamide (TC) for four or six cycles, treated from January 2010 to December 2021. Patients were included from four cancer institutions, both private and public, located in the South, Southeast, and Northeast of Brazil. Objectives: To investigate the clinical-pathological characteristics and survival of earlystage HER2-negative breast cancer patients who received four (TC4) or six cycles (TC6) of adjuvant docetaxel and cyclophosphamide (TC). Results: We collected data from six hundred and ninety-eight patients, 98.7% were female with an average age of 52 years, 51.9% were postmenopausal, 14.6% BRCA gene mutation, 66% had some comorbidity, and only 8.4% were not candidates for anthracyclines. Two hundred and twenty-five patients had public and 473 private health insurance. About 13.2% of the patients were hormone receptor negative (HR-) and 86.8% hormone receptor positive (HR+), 57.4% breast-conserving surgery and 77.7% sentinel lymph node (SL). Five hundred sixty-four (80.8%) patients received TC4 and 134 (19.2%) TC6. We observed that patients who received TC 6 had unfavorable prognostic factors such as: (TC4 vs TC6) previous breast cancer (8.7% vs 16.3%) (p=0.002), invasive ductal carcinoma (IDC) (73.4 vs 86.7%) (p=0.009), histological grade 3 (HG3) (34.9 vs 42.9%) (p= 0,085) conservative surgery (59.4% vs 53%) (p=0144), SL (80.9% vs 62.2%) (p =0.001), Lymph node positive (15% vs 42.3%) (p=0.001), pathological stage II (37.5% vs 50%) (p=0.001).Treatment completion rates were 96.5% and 84.3% for TC4 and TC6, respectively (p=0,02). The incidence of grade 3 or higher toxicity with TC6 (14% vs 21.1%; p= 0,043). Febrile neutropenia was observed in 6.7% of both groups. Grade 3 or higher neuropathy was most common with TC6 (2.2% vs 10.3%; p=0,163). Permanent treatment discontinuation was more frequent in the TC6 group (3.4% vs. 9.8%; p=0,004), as well as late toxicity (3.4% vs. 9.2%; p=0,004). Ninety-four percent of the patients completed the proposed cycles of chemotherapy, 72% received adjuvant radiotherapy and 85.4% received adjuvant hormone therapy, with 42% of these receiving an aromatase inhibitor for 5 years. The median follow-up of the entire cohort was 61 months. There was no difference in the 5-year DFS (77.5% vs. 64.7%; p=0.159) or the 5-year OS (89.5% vs. 70.5%; p= 0,06) between patients treated with TC4 and TC6. Conclusion: TC6 was commonly used for patients with unfavorable prognostic factors as history of previous breast cancer, (IDC), HG III, lymph node positive and stage II. Patients who received TC6 had less chance of completing the treatment and more severe toxicity, especially late peripheral neuropathy. There was no difference in DFS or OS. Citation Format: Mila Kraychete, Marcelle Cesca, Guilherme Almeida, Leonardo Santana, Luciana Leite, Solange M. Sanches, Vladmir Cordeiro de Lima, Rafaela Pirolli, Rafael Manea, Felipe Kaneta, Jean Coutinho, Lucas Vian, Waires Zeviani, Marcio Reis, Luciana Landeiro, Clarissa Mathias, Geila Nunez, Tamara Santana, Monique Tavares. Clinical-pathological determinant factors to choose between four or six cycles of adjuvant chemotherapy with docetaxel/cyclophosphamide (TC) in a retrospective real-world cohort of HER2-negative breast cancer patients [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO5-02-14.

Climate Change, Air Pollution, and Human Health in the Kruger to Canyons Biosphere Region, South Africa, and Amazonas, Brazil: A Narrative Review

Climate Change, Air Pollution, and Human Health in the Kruger to Canyons Biosphere Region, South Africa, and Amazonas, Brazil: A Narrative Review

Biomarkers of oxidative stress and bioaccumulation of trace metals in waterbirds from different rice fields systems

AbstractWe compared trace metal concentrations (Pb, Zn, Cd, Cu) in feathers and biomarkers in muscle and liver tissue of waterbirds from organic and conventional irrigated rice farms in South Brazil. Cu and Pb concentrations were higher in waterbirds from conventional farms, whereas Cd and Zn levels were elevated in organic farms. Birds foraging in organic farms exhibited lower CAT and SOD activity and higher NPSH, LPO, and PC concentrations compared to those in conventional farms. Higher Cu and Pb concentrations were associated with elevated SOD and CAT activity, more prevalent in birds frequenting conventional farms. Conversely, birds with higher Cd and Zn concentrations showed increased NPSH, LPO, and PC levels and were more common in organic farms. Our study underscores complex differences in trace metal accumulation and oxidative stress biomarkers among waterbirds in organic and conventional rice crops.

Serological Profile for Major Respiratory Viruses in Unvaccinated Cows from High-Yielding Dairy Herds.

This study aims to determine the serological profile of high-yielding dairy cows for four main viruses (bovine alphaherpesvirus 1 (BoAHV1), bovine viral diarrhea virus (BVDV), bovine parainfluenza virus 3 (BPIV3), and bovine respiratory syncytial virus (BRSV)) related to bovine respiratory disease (BRD) in cattle herds worldwide. In this survey, 497 blood serum samples were collected from non-vaccinated dairy cows without clinical respiratory signs in 39 herds in the central-eastern mesoregion of Paraná State, South Brazil. The presence of neutralizing antibodies was determined by virus neutralization (VN) tests. VN antibodies against BoAHV1, BVDV, BPIV3, and BRSV were detected in 355 (71.4%), 280 (56.3%), 481 (96.8%), and 315 (63.4%) serum samples, respectively. The frequencies of seropositive herds for BoAHV1, BVDV, BPIV3, and BRSV were 79.5 (n = 31), 82.0 (n = 32), 100 (n = 39), and 84.6% (n = 33), respectively. The frequencies of seropositive cows varied according to the type of herd management and the number of cows in the herd. The detection of VN antibodies in unvaccinated dairy cattle herds demonstrated the endemic circulation of the four viruses in the herds evaluated. For BRD prevention, it is recommended to implement a vaccination program for cows that provides passive immunity in calves and active immunity in cows.

LONG COVID AND ASSOCIATED FACTORS IN INDIVIDUALS FROM SOUTHERN BRAZIL: A POPULATION-BASED STUDY SULCOVID-19

The present study aimed to verify the prevalence and factors associated with COVID-19 and describe the main residual symptoms in individuals from the extreme south of Brazil. This is a cross-sectional study with 2,919 individuals older than 18 years diagnosed with COVID-19 in the period from December 2020 to March 2021 and who continued with symptoms after 6-9 months of infection. The prevalence of long COVID was 48.3% (95% CI 46.5; 50.1). The most prevalent residual symptoms were fatigue, memory loss, loss of attention, headache, loss of smell, muscle pain, and loss of taste. The groups most likely to develop long COVID were female, had anxiety, hypertension, heart problems, diabetes mellitus, musculoskeletal problems, respiratory problems, previous morbidities, and hospital admission. Physical activity and self-perception of good and very good health were protective factors for the outcome. When adjusted, female gender, anxiety, morbidities, and hospitalization remained associated with the outcome. This study showed that half of the individuals developed long COVID after 6-9 months of infection, highlighting female individuals and those with chronic conditions, demanding the creation of public policies that promote comprehensive and continued assistance to them.

Accuracy assessment of global DEMs for the mapping of coastal flooding on a low-lying sandy environment: Cassino Beach, Brazil

Projected sea level rise in the 21st century, driven by climate change, threatens low-lying coastal areas with the risk of persistent flooding. Accurately estimating flooding extent and depth is crucial to implementing effective coastal management, with digital elevation models (DEMs) playing a pivotal role. Intrinsic inaccuracies of DEMs might lead to uncertainty in the flooding projections due to SLR scenarios, which are problematic for decision-makers. This work assessed the accuracy of five global digital elevation models for coastal flooding mapping on a low-lying sandy coastal environment in the south of Brazil (Cassino Beach). Five global DEMs were assessed, namely ALOS-AW3D30, ALOS-PALSAR, ASTER, SRTM, and TanDEM-X, and a high-resolution digital elevation model (created using local aerial vehicle (UAV) imagery) was used as a benchmark. A morphometric comparison was conducted between the five global DEMs and the high-resolution local DEMs. Several statistical metrics were calculated, including the root mean squared error, correlation coefficient, and bias.Additionally, flood depths and extent were computed for different scenarios of sea level rise, and comparisons between the different DEMs were quantified. Results show that among the DEMs evaluated, TanDEM-X DEM achieved the highest correlation with the UAV DEM elevation in the beach and dune region, presenting R² equal to 0.56 and RMSE equal to 0.88 m. On the other hand, the ALOS-AW3D30, ALOS-PALSAR, ASTER, and SRTM DEMs presented low correlation and RMSE values above 2.49 m. The analysis of coastal flooding extension and depths confirms that the TanDEM-X DEM exhibited the highest similarity with the UAV DEM across various sea level scenarios, and it was the only global DEM analyzed capable of capturing dune depressions and roads, which serve as primary pathways for flooding in the type of coastal region under consideration.