South India Research Articles

Source parameter and tectonic implications of small earthquakes originating in South India

A data collection of 80 local earthquakes (1.8 < ML < 3.5) recorded by several seismic stations beneath South India from February 2009 to October 2012 was studied to estimate the source parameter characteristics. The result shows that the seismic moments (M0) vary from 8.95×1011to 6.56×1013 Nm, while source radii (r) are between 120 and 150 m. The source radius seems to be independent of magnitude and smaller within a major part of the region. This can be due to local earthquakes that may originate in the region from either the brittle shear-failure mechanism on faults or the presence of weakened zones in this region. The estimated stress drops values range from 0.20 to 3 MPa for most of the events and shows an increasing trend with the seismic moment, indicating a wide range of strength of crustal rocks. Few lower crustal event exhibits slightly elevated stress drop (4–10 MPa) values, and these cannot be solely attributed to a single model; instead, it appears that the potential contributing factors vary area wise. The corner (fc) and high cut (fmax) frequency values are bit scattered with the seismic moment, and the possible explanation would be either a complex rupture process or the involvement of a long period spectrum in the component. Both fmax and fc show a decreasing trend against seismic moments, indicating that both are caused by a source process and independent of epicentral distances and focal depths. However, source displacement D(0.006 and 0.04 m) and radiated seismic energy (Es) increases linearly with the seismic moment and is an indication of the size dependency feature. We established various empirical relationships between source parameters, including MW - ML and log(M0) - ML and proposed the ML- MW relationship for the study region, which is MW∝ 0.62ML. Overall, the present study indicates that most source parameters tend to vary with the size of the earthquake and generally follow the global model of small magnitude earthquakes. The information, we gained through this study provides insight into earthquake size, source physics, and that can help the scientific community significantly, to better understand, mitigate, and respond to the seismic hazards posed by earthquakes in the studied area.

Efficacy and tolerability of a 4-month ofloxacin-containing regimen compared to a 6-month regimen in the treatment of patients with superficial lymph node tuberculosis: a randomized trial

BackgroundTuberculosis (TB) lymphadenitis is the most common form of extra-pulmonary TB, and the treatment duration is six months. This non-inferiority based randomized clinical trial in South India evaluated the efficacy and safety of a four-month ofloxacin containing regimen in tuberculosis lymphadenitis (TBL) patients.MethodsNew, adult, HIV-negative, microbiologically and or histopathologically confirmed superficial lymph node TB patients were randomized to either four-month oflaxacin containing test regimen [ofloxacin (O), isoniazid (H), rifampicin (R), pyrazinamide (Z) -2RHZO daily/ 2RHO thrice-weekly] or a six-month thrice-weekly control regimen (2HRZ, ethambutol/4RH). The treatment was directly observed. Clinical progress was monitored monthly during and up to 12 months post-treatment, and thereafter every three months up to 24 months. The primary outcome was determined by response at the end of treatment and TB recurrence during the 24 months post-treatment.ResultsOf the 302 patients randomized, 298 (98.7%) were eligible for modified intention-to-treat (ITT) analysis and 294 (97%) for per-protocol (PP) analysis. The TB recurrence-free favourable response in the PP analysis was 94.0% (95% CI: 90.1–97.8) and 94.5% (95% CI: 90.8–98.2) in the test and control regimen respectively, while in the ITT analysis, it was 92.7% and 93.2%. The TB recurrence-free favourable response in the test regimen was non-inferior to the control regimen 0.5% (95% CI: -4.8-5.9) in the PP analysis based on the 6% non-inferiority margin. Treatment was modified for drug toxicity in two patients in the test regimen, while one patient had a paradoxical reaction.ConclusionThe 4-month ofloxacin containing regimen was found to be non-inferior and as safe as the 6-month thrice-weekly control regimen.

Power Relations in Optimisation of Therapies and Equity in Access to Antibiotics (PROTEA) Study: investigating the intersection of socio-economic and cultural drivers on antimicrobial resistance (AMR) and its influence on healthcare access and health-providing behaviours in India and South Africa

Across social structures within society, including healthcare, power relations manifest according to gender, socioeconomic status, race, ethnicity, and class influencing infection related healthcare access and health providing-behaviours. Therefore, accounting for sociocultural drivers, including gender, race, and class, and their influence on economic status can improve healthcare access and health-providing behaviours in infection prevention and control (IPC) as well as antibiotic use, which in turn helps mitigate the spread of antimicrobial resistance (AMR). This Wellcome funded research will investigate how and why the social determinants of health and economic status influence how people seek, experience, and provide healthcare for suspected or proven (bacterial) infections and how these factors influence antibiotic prescribing and use in South Africa (upper middle-income country) and India (lower middle-income country). The aim of this body of work is to, (1) define and estimate the sociocultural and economic drivers for AMR in different resource settings, (2) design, implement and evaluate context-sensitive IPC and antimicrobial stewardship (AMS) interventions, and (3) inform policy and strategy for AMR mitigation. The population will be healthcare workers (HCWs), patients, and their carers across acute medical and surgical pathways where IPC and antibiotic-related healthcare access and health-providing behaviours will be studied. Qualitative methods will include ethnographic research, semi-structured in-depth interviews, and focus groups with healthcare providers, patients and carers. Quantitative analysis of bedside observational data from hospitals and population level data on antibiotic use will study the various predictors of AMR using bivariable and multivariable regression analyses. The research will provide high-quality evidence on how social determinants intersect with health, social well-being, and vulnerability in IPC practices and antibiotic use. Using this knowledge we will: 1) design, implement, and measure effects of interventions accounting for these factors; 2) provide a toolkit for advocacy for actors in AMR, and healthcare to assist them to promote dialogue, including policy dialogue on this issue. This work directly benefits the target population and informs healthcare services and practice across the participating countries with potential for wider translation. The setting will be hospitals in South Africa (middle-income country) and India (lower middle-income country). The population will be healthcare workers (HCWs), patients, and their carers across acute medical and surgical pathways where IPC and antibiotic-related health-seeking and health-providing behaviours will be studied. These populations represent communities most affected by infections and AMR because existing interventions do not address a) differences in how surgical versus medical teams manage infections; b) the role of the wider social network of individuals on their decision-making, c) intersection of the social determinants of health including race, gender, socioeconomic deprivation with AMR.

Comparative Efficacy of Magnetic Resonance Cholangiopancreatography vs. Percutaneous Transhepatic Cholangiography With Percutaneous Transhepatic Biliary Drainage Stenting in Evaluating Obstructive Jaundice: A Prospective Study in South India

Comparative Efficacy of Magnetic Resonance Cholangiopancreatography vs. Percutaneous Transhepatic Cholangiography With Percutaneous Transhepatic Biliary Drainage Stenting in Evaluating Obstructive Jaundice: A Prospective Study in South India

Vīrabhadra, the Dreadful Destroyer of Sacrifice

When Śiva is not invited to the great sacrifice organised by Dakṣa, his bride Satī’s father, he emanates from himself the terrible Vīrabhadra, who completely destroys the sacrificial arena. The remote origins of this mythical story, which is extensively narrated especially in the Purāṇas, lie in some myths concerning Rudra, Śiva’s Vedic-Brahmanic precursor. The cult of Vīrabhadra spread throughout South India during the Vijayanagara empire, mainly thanks to the Śivaite sect of the Vīraśaivas. The long-lasting diffusion of his cult is also demonstrated by the wide production of metal plaques depicting this god. A few years ago the art collectors Paola and Giuseppe Berger donated a conspicuous collection of these plaques to the Veneranda Accademia Ambrosiana of Milan; they are currently on display in the Pinacoteca Ambrosiana. Many of these plaques are possibly attributable to the 18th and 19th centuries and their exact provenance cannot be defined at the present stage of studies, but most of them presumably come from Karnataka. They show an almost constant basic iconography, but also a wide range of different artistic languages. Here we propose a general analysis of this repertoire, and a more detailed description of some of the specimens.

Spaza Shops in Townships and Rural Areas to Switch to Electronic Payment Method to Run the Business Successfully and Safe: Case Study Mkhuhlu Township, Bushbuckridge Municipality, Mpumalanga In South Africa

The purpose of this study was to investigate whether spaza shop (tuck shop) owners in South Africa utilise mobile communication technologies. Secondly, it evaluated opportunities created using mobile communication. Interviews were conducted with 110 small, micro- and medium enterprises (SMMEs) operating spaza business shops in Mkhuhlu and Calcutta in the Bushbuckridge Municipality in Mpumalanga. Police officers, residents of South Africa, Somalians and Indians were interviewed. Data were collected through self-completion questionnaires. Interviews were conducted in English as most of the races did not understand an African language. Findings more technical and Technological skills are needed for the township business owners. Safety and security must support SMMEs in townships by protecting their owners and their resources against criminals.

Association of maternal and cord vitamin B12 levels with anthropometry in term neonates born to malnourished mothers in coastal South India.

Malnourished pregnant women are at increased risk of micronutrient deficiency. We assessed the vitamin B12 status in both malnourished and normally nourished pregnant women and their neonates. Additionally, we studied the association between maternal B12 levels, cord B12 levels and neonatal anthropometry. This cross-sectional study enrolled 63 malnourished and 63 normally nourished mothers and neonates. Maternal and cord blood samples were collected at the time of delivery for estimation of vitamin B12 levels. Maternal and cord vitamin B12 levels were compared using the Mann-Whitney U test. Neonatal anthropometry was correlated with maternal and cord B12 levels using Spearman's correlation. Data were analyzed using SPSS version 25. Mean maternal age was 26.58 yrs. The median cord B12 levels were lower than the maternal B12 levels. Maternal B12 levels showed a strong positive correlation with cord B12 levels (rho = 0.879; p < 0.001). Maternal (p < 0.001) and cord (p < 0.001) vitamin B12 levels were significantly lower in the malnourished group than in the normally nourished group. In malnourished group, 66.8% mothers and 95.2% neonates were Vitamin B12 deficient, whereas 1.5% mothers and 4.7% neonates were vitamin B12 deficient in normally nourished group. In the malnourished group, maternal B12 levels were positively correlated with birth weight (rho 0.363, p = 0.003) and length (rho 0.330, p =0.008), whereas cord B12 levels were positively correlated with birth weight in the normally nourished group. (rho 0.277 p= 0.028). High rates of vitamin B12 deficiency were observed in malnourished mothers and neonates. There was a positive correlation between birth weight, length, and maternal vitamin B12 levels in malnourished mothers. These findings emphasize the need to address maternal malnutrition and vitamin B12 deficiency to improve neonatal health.

Clinical Profile of Dengue Seropositive Infection From a Tertiary Care Hospital Situated in Mysuru, South India

Clinical Profile of Dengue Seropositive Infection From a Tertiary Care Hospital Situated in Mysuru, South India

Predicting COVID 19-Associated Pulmonary Aspergillosis Risk in Low- and Middle-Income Countries: A Matched Case-Control Study.

Coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) is a life-threatening fungal infection. Studies focusing on CAPA in low- and middle-income countries are limited. This retrospective matched case-control study was conducted at a tertiary care center in South India. Cases of CAPA were classified using the 2020 European Confederation of Medical Mycology/International Society for Human and Animal Mycology consensus criteria. A total of 95 cases were matched 1:1 with COVID-19 patients without CAPA. Matching was done based on age and period of admission. Inverse probability weighting was used to account for imbalances in COVID-19 severity and intensive care unit (ICU) admission. Data on demographics, clinical details, microbiologic and radiologic data, and treatment outcomes were collected. A predictive score for CAPA was developed from baseline risk factors. The predictive score identified lymphopenia, European Organisation for Research and Treatment of Cancer risk factors, and broad-spectrum antibiotic use as the main risk factors for CAPA. Positivity for bacterial pathogens in blood or bronchoalveolar lavage samples reduced the risk of CAPA. The predictive model performed well in cross-validation, with an area under the curve value of 82%. CAPA diagnosis significantly increased mortality and shift to ICU. The predictive model derived from the current study offers a valuable tool for clinicians, especially in high-endemic low- and middle-income countries, for the early identification and treatment of CAPA. With further validation, this risk score could improve patient outcomes.

Correlates of disability among primary care patients with common mental disorders and chronic medical conditions- a cross-sectional study from rural South India.

We examined the correlates of disability among people with non-communicable diseases (NCDs) and comorbid common mental disorders (CMDs) from rural India. The sample comprised 2,486 participants enrolled in a cluster randomized trial (cRCT), Healthier OPtions through Empowerment (HOPE). Participants were 30 years or older, with a diagnosis of major depressive disorder, dysthymia, generalized anxiety disorder, and/or panic disorder on the MINI-International Neuropsychiatric Interview, with hypertension, diabetes, dsylipidemia and/ or ischemic heart disease. Disability was measured with the 12-item version of WHODAS 2.0. The severity of depression and anxiety was measured using the Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder Scale (GAD-7), respectively. Multiple linear regression analyses were used to examine associations. The mean age was 59 ± 10.0 years, three quarters (1864) of the participants were female, and 64.0% were married. More than half of the participants had no formal education (57.9%). Most of the participants had two or more chronic medical conditions (73.0%). The mean disability score was 24.3. The mean depression score was 8.5, and the mean anxiety score was 6.7. Higher levels of disability were reported by participants ≥ 60 years of age, those with moderate and severe depression, and moderate anxiety. Among female participants, being unmarried was associated with greater disability. Male participants without formal education reported greater levels of disability. Higher severity of CMDs is significantly associated with higher levels of disability. For women, being unmarried and for men having no formal education was associated with higher levels of disability. ClinicalTrials.gov NCT02310932 [URL: https://clinicaltrials.gov/ct2/show/record/NCT02310932 ] registered on December 8, 2014, and Clinical Trials Registry India CTRI/2018/04/013001, registered on April 4, 2018. Retrospectively registered.

Elucidating the Immune Response to SARS-CoV-2: Natural Infection versus Covaxin/Covishield Vaccination in a South Indian Population

A natural infection or a vaccination can initially prime the immune system to form immunological memory. The immunity engendered by vaccination against COVID-19 versus natural infection with SARS-CoV-2 has not been well studied in the Indian population. In this study, we compared the immunity conferred by COVID-19 vaccines to naturally acquired immunity to SARS-CoV-2 in a South Indian population. We examined binding and neutralizing antibody (NAb) levels against the ancestral and variant lineages and assessed the ex vivo cellular parameters of memory T cells, memory B cells, and monocytes and finally measured the circulating cytokine response. COVID-19 vaccination stimulates heightened levels of IgG antibodies against the original strain of SARS-CoV-2, as well as increased binding to the spike protein and neutralizing antibody levels. This enhanced response extends to variant lineages such as B.1.617.2 (Delta, India), B.1.1.529 (Omicron, India), B.1.351 (Beta, South Africa), and B.1.1.7 (Alpha, UK). COVID-19 vaccination differs from SARS-CoV-2 infection by having increased frequencies of classical memory B cells, activated memory B and plasma cells, CD4/CD8 T cells of effector memory, effector cells, stem cell-like memory T cells, and classical and intermediate monocytes and diminished frequencies of CD4/CD8 T cells of central memory and non-classical monocytes in vaccinated individuals in comparison to those with natural infection. Thus, COVID-19 vaccination is characterized by enhanced humoral responses and robust activation of innate and memory T cell responses in comparison to natural infection in a South Indian population.

Pre-eradication updated seabird survey including new records on Amsterdam Island, southern Indian Ocean

Pre-eradication updated seabird survey including new records on Amsterdam Island, southern Indian Ocean

Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome: A Case Report From South India

Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome: A Case Report From South India

First Report for Painted Globular Frog Uperodon taprobanicus in North Bastar Kanker District of Chhattisgarh, (India)

The North Bastar Kanker is full of natural wealth where different types of species are found every year, out of which new species are found the Painted Globular Frog (Uperodon taprobanicus) has been seen for the first time, according to the current study. One year of observation throughout the village badgaon near Khandi Rivershowed this species to be present in this microhabitat. The species' taxonomic validity in the area was aided by morphological and photographsanalysis that validated its identification. The known distribution range of U. taprobanicus, which was previously primarily reported in South India and Sri Lanka, is expanded by this finding. In order to shed light on the state of the species' conservation in this area, ecological characteristics like habitat choice, microhabitat usage and potential threats were also evaluated. The exploration underscores the importance of continued monitoring and conservation efforts to safeguard the diversity of amphibians in Chhattisgarh and highlights the need for further research to elucidate the ecological requirements and population dynamics of U. taprobanicus in its newly identified habitat. This species has been marked in the IUCN data and its conservation is very important in time. If we cannot conserve it, then we will eliminate this species from our ecosystem and we may see natural calamity and loss in the near future.

Burden of Chronic Kidney Disease of Undetermined Aetiology (CKDu) in a Tertiary Care Public Hospital in North India.

Chronic kidney disease of undetermined aetiology (CKDu) is an important public health problem. Indian data are mostly based on studies from rural regions in south and east India. We examined the burden and profile of CKDu in patients attending a tertiary care hospital in north India. We assessed records of consecutive new CKD patients registered in a nephrology clinic from January 2015 to June 2022. Patients were classified as having CKDu based on predefined inclusion and exclusion criteria. Clinical and laboratory parameters at presentation and kidney biopsy when done were noted. Records of 32,369 patients with CKD were screened, and 29,663 were included (2,706 excluded due to inadequate data). A total of 370 (1.2%) patients were categorized as CKDu. Mean age was 41 ± 14.7 years, 58.1% being male. Of them, 158 (42.7%) patients were in CKD stage 3, 89 (24.1%) in stage 4, 84 (22.7%) in stage 5, and 39 (10.5%) were dialysis dependent at presentation; 232 (62.7%) patients had proteinuria &lt;0.5 gm/day and 138 (37.3%) between 0.5 and 1 gm/day. Renal histology was available for 65 CKDu patients: 62 had chronic tubulointerstitial nephritis (CTIN) and 3 had non-specific changes. When defined using strict criteria with intensive diagnostic workup, burden of CKDu is low in our hospital-based cohort of CKD patients. CTIN is the predominant histopathological finding in kidney biopsy.

Perilampus gowriae sp. nov. and the rediscovery of Krombeinius eumenidarum Bouček (Hymenoptera: Perilampidae) from South India

ABSTRACT A new species of the cosmopolitan genus Perilampus Latreille, 1809 (Perilampidae) is described from south India with illustrations and its association with an unidentified Charops (Hymenoptera: Ichneumonidae) pupa is recorded. The euminine parasitising perilampid, Krombeinius eumenidarum Bouček, 1978 (Perilampidae) is rediscovered and illustrated, also validating its host association with Paraleptomenes miniatus mephitis (Cameron, 1901) (Hymenoptera: Vespidae: Eumeninae) from south India. A checklist of Perilampidae occurring in India is also provided. http://www.zoobank.org/urn:lsid:zoobank.org:act:88B760A0-CA1D-4217-A5CA-54989FD66FB8

Spectrum of Inpatient Pediatric Dermatology Cases at a Tertiary Health Care Centre in South India

Spectrum of Inpatient Pediatric Dermatology Cases at a Tertiary Health Care Centre in South India

Drivers of PM2.5 Episodes and Exceedance in India: A Synthesis From the COALESCE Network

AbstractEmission sources influencing high particulate air pollution levels and related mortality in India have been studied earlier on country‐wide and sub‐national scales. Here, we use novel data sets of emissions (for 2019) and observations created under the Carbonaceous Aerosol Emissions, Source Apportionment, and Climate Impacts network in India (Venkataraman et al., 2020, https://doi.org/10.1175/bams‐d‐19‐0030.1) in WRF‐Chem simulations to evaluate drivers of high PM2.5 levels during episodes and in airsheds with different pollution levels. We identify airsheds in “extreme” (110–140 μg/m3), “severe” (80–110 μg/m3) and “significant” (40–80 μg/m3) exceedance of the Indian annual ambient air quality standard (National Ambient Air Quality Standards [NAAQS]) of 40 μg/m3 for PM2.5. We find that primary organic matter and anthropogenic mineral matter (largely coal fly‐ash) drive high PM2.5 levels, both annually and during high PM2.5 episodes. PM2.5 episodes are driven by organic aerosol in north India (Mohali) in wintertime but are additionally influenced by mineral matter and secondary inorganics in central (Bhopal), south India (Mysuru) and eastern India (Shyamnagar). Across airsheds in exceedance of the NAAQS and during high PM2.5 episodes, primary PM2.5 emissions arise largely from the residential sector (50%–75%). Formal sector emissions (industry, thermal power and transport; 40%–55%) drive airshed and episode scale PM2.5 exceedance in northern and eastern India. Agricultural residue burning emissions predominate (50%–75%) on episode scales, both in northern and central India, but not on annual scales. Interestingly, residential sector emissions strongly influence (60%–90%) airsheds in compliance with the NAAQS (annual mean PM2.5 &lt; 40 μg/m3), implying the need for modern residential energy transitions for the reduction of ambient air pollution across India.

Reconciling Religion, Reform and Modernity: A Study of Early Muslim Women’s Periodicals from South India

This study analyses the women’s periodicals that were in circulation among the Muslims of Kerala, South India, during the early twentieth century. They were published by small-scale print houses and Muslim women associated with these periodicals as writers, editors and publishers, shaping a highly porous public sphere unlike the nationalist and colonial homogenous imaginations of the public. These early writings from Muslim women expose the entanglement of imagined rights and community identity embodied in faith and piety in colonial modernity. They ought to be studied to understand how social identity drew considerably from the domains of religion and community, if not region, and that gender and nation played less significant roles in their imagination of modernity. Moreover, their engagement with the West was not determined in the context of resistance to colonial administration alone, but also in a deeper and more complex history of Islam’s encounters with it.

A Comprehensive Review of Surface Ozone Variations in Several Indian Hotspots

Ozone at ground level (O3) is an air pollutant that is formed from primary precursor gases like nitrogen oxides (NOx) and volatile organic compounds (VOCs). It plays a significant role as a precursor to highly reactive hydroxyl (OH) radicals, which ultimately influence the lifespan of various gases in the atmosphere. The elevated surface O3 levels resulting from anthropogenic activities have detrimental effects on both human health and agricultural productivity. This paper provides a comprehensive analysis of the variations in surface O3 levels across various regions in the Indian subcontinent, focusing on both spatial and temporal changes. The study is based on an in-depth review of literature spanning the last thirty years in India. Based on the findings of the latest study, the spatial distribution of surface O3 indicates a rise of approximately 50–70 ppbv during the summer and pre-monsoon periods in the northern region and Indo-Gangetic Plain. Moreover, elevated levels of surface O3 (40–70 ppbv) are observed during the pre-monsoon/summer season in the western, southern, and peninsular Indian regions. The investigation also underscores the ground-based observations of diurnal and seasonal alterations in surface O3 levels at two separate sites (rural and urban) in Kannur district, located in southern India, over a duration of nine years starting from January 2016. The O3 concentration exhibits an increasing trend of 7.91% (rural site) and 5.41% (urban site), ascribed to the rise in vehicular and industrial operations. This review also presents a succinct summary of O3 fluctuations during solar eclipses and nocturnal firework displays in the subcontinent.