A field experiment was conducted during summer 2015 at Navsari (Gujarat) to study the effect of spacing and nutrient management on summer sesame (Sesamum indicum L.) under south Gujarat conditions. Among almost all the growth and yield attributes, maximum plant height and minimum number of branches/plant, dry matter production/plant, seed yield/plant, number of capsules/plant and number of seeds/capsule were recorded with spacing of 30 cm x 10 cm. While, maximum seed yield, straw yield, oil yield, nutrient uptake, net realizationand BCR were recorded with spacing of 45 cm x 10 cm. Among all the growth and yield attributes, maximumplant height, number of branches/plant, dry matter production/plant, number of capsules/plant, number of seeds/capsule, seed yield/plant, seed yield and straw yield, were recorded with the application of 100% RDF, i.e. 50-25-0 kg N-P2O5-K2O/ha). Treatments receiving 100% RDF realized the highest net realization of 35477` ha with the highest BCR of 2.69.