Abstract Background Cancer prevention literacy (CPL) is essential for empowering individuals to make health-informed decisions and adopt preventive measures to reduce their cancer risk. This study aims to measure CPL among the European population. Methods A cross-sectional population-based study was conducted from February to March 2024 among European residents over 18 years old (N = 2312) in the context of BUMPER Project (https://bumper.cancer.eu/). An online self-administered questionnaire was developed including: sociodemographic characteristics (age, gender, country of residence, educational level), and CPL (general and by European Code Against Cancer -ECAC- topics). A descriptive analysis was performed and the chi-square and Kruskal-Wallis test were calculated to examine the relationship between CPL and sociodemographic variables. Results 44.2% showed a high level of CPL, followed by 39.5% with medium, and 16.3% with low level. 61.1% of participants are not aware of ECAC. ECAC topics with higher levels of knowledge are: UV exposure (88.3%), pollution (81.6%), tobacco (78.7%), second-hand smoking (60.9%). ECAC topics with lower levels are: hormone replacement therapy (47.9%), breastfeeding (41.6%), and vaccination (32.9%). Statistically significant differences (p < 0.05) are observed in CPL level by gender, country of residence, and educational level. Those with a higher % of low CPL levels are men (22.8%), people from West and South Europe (20.8% and 18.1%), and primary education level (34.7%). Conclusions CPL level is medium-high among the European population, with social and gender inequalities. Further studies are needed to delve into these inequalities. Key messages • The cancer prevention literacy level is medium-high among the European population, with social and gender inequalities. • There is a need of tailored interventions to address social inequalities in cancer prevention literacy among European population.