South East England Research Articles

A decade of Campylobacter and Campylobacter bacteraemias in a district general hospital and the surrounding London and South East region, England

Campylobacter bacteraemia is a rare complication of the most common bacterial gastrointestinal infection but is associated with significant morbidity and mortality. There is limited data describing current trends in surveillance and antimicrobial resistance for the Campylobacter strains involved. At the Epsom and St Helier's University Hospital (ESTH), we noted a marked increase in Campylobacter bacteraemia infections in 2021. We extracted Campylobacter reports using the UK Health Security Agency's (UKHSA) Second Generation Surveillance System (laboratory reporting system) between 1st January 2012 and 31st December 2021. We reviewed patient records of patients with Campylobacter bacteraemia for details including presentation, past medical history, duration of hospital stay, and antibiotic use. Between 2012 and 2021, ESTH reported a total of 34 cases of Campylobacter bacteraemia. In 2021, the estimated incidence was 6.8 cases per 100,000 population and in the surrounding area, the incidence was 0.4 per 100,000 population. The incidence rate of Campylobacter bacteraemia in London and the South East region was significantly lower than ESTH (RR = 0.17, p<0.0001). Campylobacter bacteraemia cases at ESTH reported a high number of co-morbidities (average number of comorbidities = 2.3) and had a duration of stay in hospital of a median of 7 days (IQR = 4-10 days). Campylobacter jejuni was the most commonly reported species for stool and blood Campylobacter in ESTH, London, and South East England. Campylobacter bacteraemia reports at ESTH were significantly (p<0.001) higher than the surrounding London and South East region. While no common cause for the exceedance of Campylobacter bacteraemia has been identified, common risk factors for Campylobacter bacteraemia infection include underlying health conditions, being older, and male.

Housing Support Services and the Strengths-Based Approach: Service-User and Staff Perspectives

This study aimed to identify main themes in the accounts of individuals encountering homelessness and staff who supported them, in a low-income South-East England town. It explored whether such themes were compatible with the adoption of a strengths-based approach by the local homelessness services. Thirty-one individuals in temporary accommodation and 19 staff were interviewed using a semi-structured schedule. Thematic analysis of the service user accounts identified five themes—Challenging Backgrounds, Effective Provision, Room for Improvement, Strengths, and Aspirations. An equal number of themes emerged from the thematic analysis of the staff interviews—Focus on Trauma and Mental Health, Service User Variability, Service User Involvement, Hard-Working Staff, and Improving Material Conditions. Both sets of narratives supported the adoption of a strengths-based approach by the local services, as they emphasized service user competencies, the importance of co-production, and the necessity to consider context in understanding the experience of homelessness. Including a range of stakeholders, future research needs to follow-up these services after they fully adopt a strengths-based approach.

Ancient, veteran and other listed trees as nest sites for wild-living honey bee, Apis mellifera, colonies

Wild-living honey bee (Apis mellifera) colonies naturally nest in old cavity-bearing trees throughout their range, but this important nesting habitat is in global decline. Here we determine the use of ancient, veteran and other listed trees as nest sites by wild-living honey bee colonies in Britain and investigate the effect of tree size, genus and management on occupancy. Over 1,000 trees of special interest (TSIs) were surveyed in southeast England using the Ancient Tree Inventory (ATI) of the Woodland Trust, a charity that protects and promotes trees in Britain. 2% of all TSIs and 4.4% of TSIs with cavities were occupied by wild-living honey bee colonies (n = 21). Occupancy positively correlated with tree diameter, which is surprising given that the overall sample already had a large mean diameter of 1.3 m. Wild-living colonies occupied sweet chestnut (Castanea sativa) more frequently than expected (7% versus 2% overall), probably due to their large mean diameter (1.6 m) and proportion of trees with cavities (73%). Heights of occupied tree cavities (including non-ATI trees) ranged from 0 to 18.2 m with a median of 6.8 m, entrance size ranged from 2.2 to 322 cm2 with a median of 33.8 cm2 and entrance orientation was not significantly different from random.

Partitioning model uncertainty in multi-model ensemble river flow projections

Floods are the largest natural disaster currently facing the UK, whilst the incidents of droughts have increased in recent years. Floods and droughts can have devastating consequences on society, resulting in significant financial damage to the economy. Climate models suggest that precipitation and temperature changes will exacerbate future hydrological extremes (i.e., floods and droughts). Such events are likely to become more frequent and intense in the future; thus to develop adaptation plans climate model projections feed hydrological models to provide future water resource projections. ‘eFLaG’ is one set of future river flow projections produced for the UK driven by UKCP18 climate projections from the UK Met Office. The UKCP18-derived eFLaG dataset provides state-of-the-art projections for a single GCM driven by RCP 8.5 across the entire UK. A QE-ANOVA approach has been used to partition contributing sources of uncertainty for two flow quantiles (Q5 high flows and Q95 low flows), at near and far future time scales, for each of the 186 GB catchments in the eFLaG dataset. Results suggest a larger hydrological model uncertainty associated with low flows and greater regional climate model uncertainty for high flows which remains stationary between flow indicators. Total uncertainty increases from near to far future and highly uncertain catchments have been identified with a high concentration in South-East England.

Spatially Explicit Correction of Simulated Urban Air Temperatures Using Crowdsourced Data.

Urban climate model evaluation often remains limited by a lack of trusted urban weather observations. The increasing density of personal weather sensors (PWSs) make them a potential rich source of data for urban climate studies that address the lack of representative urban weather observations. In our study, we demonstrate that carefully quality-checked PWS data not only improve urban climate models' evaluation but can also serve for bias correcting their output prior to any urban climate impact studies. After simulating near-surface air temperatures over London and south-east England during the hot summer of 2018 with the Weather Research and Forecasting (WRF) Model and its building Effect parameterization with the building energy model (BEP-BEM) activated, we evaluated the modeled temperatures against 402 urban PWSs and showcased a heterogeneous spatial distribution of the model's cool bias that was not captured using official weather stations only. This finding indicated a need for spatially explicit urban bias corrections of air temperatures, which we performed using an innovative method using machine learning to predict the models' biases in each urban grid cell. This bias-correction technique is the first to consider that modeled urban temperatures follow a nonlinear spatially heterogeneous bias that is decorrelated from urban fraction. Our results showed that the bias correction was beneficial to bias correct daily minimum, daily mean, and daily maximum temperatures in the cities. We recommend that urban climate modelers further investigate the use of quality-checked PWSs for model evaluation and derive a framework for bias correction of urban climate simulations that can serve urban climate impact studies.

A102Embedding Electronic Patient Records Into Routine Medical Simulation Training Across the South East of England, a Pioneering Regional Collaboration

Electronic patient record (EPR) systems are increasingly prevalent in clinical settings, yet UK medical simulation training continues to use outdated paper-based methods for training healthcare staff. While published literature has highlighted the training benefits of incorporating EPRs into medical simulation training [1, 2], the transition has previously been hampered by a lack of bespoke software. To address this, a novel educational EPR (named SimEPR) was created, a bespoke training software designed to be used on a computer at the manikin’s bedside, which features customizable clinical scenarios ( A preview of SimEPR, a novel educational electronic patient record system designed for UK medical simulation training This project aimed to incorporate SimEPR into routine medical simulation training in the South East of England, and report trainee experience using the software. Feedback data was collected from trainees who used SimEPR as part of their simulation training using an electronic feedback form. SimEPR was initially deployed in a medical school and two NHS trusts from 11th February 2021, before the project was scaled up to six additional educational centres (one university and five NHS trusts) from 3rd January 2023. Data from 209 trainees was collected, of which 16% were medical students, 82% were foundation doctors and 2% were post-foundation doctors. Out of these, 86% reported that, compared to using paper notes, the educational EPR created a more realistic training experience. Meanwhile, 83% reported that the use of SimEPR helped improve their clinical learning. Last, 87% reported that they would recommend the simulation department to continue using SimEPR. SimEPR is the first software of its kind designed specifically for UK medical education, and is the product of collaboration with a number of simulation leads and NHS-affiliated organizations. As well as data supporting a higher fidelity training experience, SimEPR incorporates digital skills into practical training, thus supporting the development of a digitally-ready workforce. In addition, by eliminating the use of paper, SimEPR contributes to the sustainable delivery of simulation-based education. Further evaluation work as part of this pioneering regional project aims to collect pre- and post-training feedback, feedback from medical educators and feedback from other healthcare disciplines. In the longer term, SimEPR offers to transform the delivery of simulation training for the NHS workforce. The software’s ‘scenario-sharing’ function allows sharing of simulated patient records between institutions, supporting the standardization of training while saving staff time in building training scenarios. Furthermore, features such as performance analytics for trainee feedback, and AI technology to generate interactive scenarios, are being explored. Authors confirm that all relevant ethical standards for research conduct and dissemination have been met. The submitting author confirms that relevant ethical approval was granted, if applicable.

Developing a risk prediction tool for lung cancer in Kent and Medway, England: cohort study using linked data

BackgroundLung cancer has the poorest survival due to late diagnosis and there is no universal screening. Hence, early detection is crucial. Our objective was to develop a lung cancer risk prediction tool at a population level.MethodsWe used a large place-based linked data set from a local health system in southeast England which contained extensive information covering demographic, socioeconomic, lifestyle, health, and care service utilisation. We exploited the power of Machine Learning to derive risk scores using linear regression modelling. Tens of thousands of model runs were undertaken to identify attributes which predicted the risk of lung cancer.ResultsInitially, 16 attributes were identified. A final combination of seven attributes was chosen based on the number of cancers detected which formed the Kent & Medway lung cancer risk prediction tool. This was then compared with the criteria used in the wider Targeted Lung Health Checks programme. The prediction tool outperformed by detecting 822 cases compared to 581 by the lung check programme currently in operation.ConclusionWe have demonstrated the useful application of Machine Learning in developing a risk score for lung cancer and discuss its clinical applicability.

Medicine burden experiences of people living with HIV and association with stigma

ABSTRACT The medicine burden of people living with HIV (PLWH) is unknown. Between 2018 and 2020, participants completed a survey comprising outcome measures for medicine burden (LMQ-3) and stigma experiences (SSCI-8). Participants were HIV+ adults (≥18 years), using antiretrovirals (ARV) with or without non-ARV medicines, recruited via two outpatient clinics in southeast England and online via HIV charities across the UK. Spearman’s correlations between medicine burden levels and stigma scores were calculated. Participants were mostly males (72%, 101/141) of mean (SD) age 48.6 (±12.31) years. Total number of medicines ranged from 1-20. High medicine burden was self-reported by 21.3% (30) and was associated with polypharmacy (≥ 5 medicines) (101.52 Vs 85.08, p = 0.006); multiple doses versus once daily regimes (109.31 Vs 85.65, p = 0.001); unemployment (98.23 Vs 84.46, p = 0.004); and ethnicity (97 Vs 86.85, p = 0.041 for non-White versus White participants). A correlation between medicine burden and stigma was observed (r = 0.576, p < 0.001). The LMQ-3 demonstrated adequate construct validity and reliability (domain loadings ranging 0.617-0.933 and Cronbach’s α of 0.714-0.932). Assessment of medicine burden and psychosocial stigma in PLWH could enable identification of those needing additional support in future research and practice.

‘Only for the white’. A qualitative exploration of the lived experiences of Black, Asian and Minority Ethnic midwifery students

BackgroundAn ethnically diverse workforce has been identified as a key component of safe, compassionate maternity care, and yet midwifery remains a predominantly White profession across the Global North. Understanding the experiences of Black, Asian and Minority Ethnic midwifery students is key to addressing this disparity. ObjectiveTo capture the university and placement experiences of Black, Asian and Minority Ethnic midwifery students in a culturally White environment. MethodsA qualitative approach underpinned by a feminist, inductive, interpretivist paradigm informed a study undertaken with student midwives studying at three separate universities in South East England. Five virtual focus groups and two semi-structured interviews were conducted with thirteen current student midwives and one preceptee (recently graduated) midwife self-identifying as Black, Asian or Minority Ethnic. Analysis was inductive, data-driven and thematic. Standards for Reporting Qualitative Research recommendations have been used to formulate this report. FindingsAlthough some participants reported positive experiences and felt well-supported, an overarching narrative emerged of midwifery as an exclusive and White profession. Institutionalised Whiteness was experienced in university, in placement and within individual student cohorts. Four themes were identified: ‘being an outsider’, ‘prejudice, discrimination and racism’, ‘nowhere to turn’ and ‘positive forces’. ConclusionsRacist and discriminatory beliefs and practices in some midwifery education and placement settings negatively impact student experience and are likely to result in poorer care being provided to Global Ethnic Majority women and families. An unwillingness among some White educators and students to recognise the presence and impact of inequitable and racist environments, and a lack of clear, acceptable, and effective pathways for students to use to raise and discuss concerns, makes it difficult to challenge and change this injustice.

On Surprises, Strategy, the Economy and What Comes Next for Scottish Independence

AbstractNicola Sturgeon's resignation as First Minister and leader of the SNP has thrown Scottish politics into flux. But beneath the superficial media coverage and frenetic party politics that followed her resignation, the fundamentals of the constitutional debate remain unaltered. One of these fundamentals, the extent to which Scotland is better or worse off being part of the UK political economy, is rarely debated in the depth it deserves. The parlous state of the UK economy and, in particular, the deeply entrenched territorial inequality that results from its extreme core‐periphery structure that safeguards the economic dominance of London and South East England, holds the potential for a surprise shift in the debate over independence to emerge.

Motivationally Appealing Computer Science e-Learning Games: An Inclusive Design Approach

Research has shown that e-learning games do not have the same level of appeal to girls, as they do to boys; particularly in the crucial 11-14 age group. In the United Kingdom, this is typically when they start to make subject choices that impact their future studies and careers. Given the shortage of females who choose computer science as a career, this study explores how e-learning games can be designed to be motivationally appealing to young learners. It further explores the role of game representations and its appeal to this age group. This empirical study addresses the research question: “Can we develop e-learning games which appeal and motivate girls of age 11-14 to study computer science concepts?” Two e-learning games were developed: one included game representations such as game colour, graphics, character, age appropriateness, storyline, number of players, violence, identified as appealing to young females and the other game included antithetical or neutral representations. The two developed prototypes were used to explore key e-learning game representations as used to teach computer science concepts. A total of 304 participants, comprising of 152 girls and 152 boys from a combination of same sex and mixed secondary schools in Southeast England, engaged with both experimental games. The experiment also elicited information on how learners interact with these games and the resulting game appeal, motivation and learning. The insight gained from the analysis of data captured during the experiments, provide the evidence to demonstrate that inclusive e-learning games which motivate and appeal to girls of age 11-14 can be developed. This can have a positive influence on their willingness to use such games to learn computer science concepts. This implies that the study found positive outcomes related to e-learning game appeal, motivation and the learning of girls of this age group. A follow-up longitudinal study could investigate the impact of significant e-learning game representations that appeal to the target group. This could provide additional evidence on the changes in the appeal of the investigated significant game representations over time, due to the influence of other factors such as socio-economic and socio-cultural differences. This understanding can further enhance inclusive e-learning strategies to improve diversity in computer science education and consequently the career pipeline.

Business model pivoting and digital technologies in turbulent environments

PurposeThis paper aims to draw on the Dynamic Capabilities View to discuss how small and medium enterprises (SMEs) use digital technologies to develop digital capabilities that will enable them to change their current business model and trajectory, that is, to pivot-within turbulent environments, and subsequently to survive and grow.Design/methodology/approachThe authors collected and analysed qualitative data from 26 SMEs in South-East England that have used digital technologies to pivot during the pandemic. The data was collected via in-depth semi-structured interviews. The authors analysed the data by creating first-order concepts, second-order themes, and aggregating dimensions.FindingsThe findings suggest that (1) digital technologies enable pivoting by facilitating the creation of the following digital capability types: “digital sensing”, “digital seizing” and “digital transforming”; (2) Each of these digital capability types is underpinned by micro-foundations (sub-capabilities) and shaped by the digital culture of the organisation. (3) these capabilities are triggered by the turbulent environment and the existing digital technologies, and are shaped by the digital culture.Originality/valueThe authors contribute to the literature of digital entrepreneurship as the authors illustrate (1) how the micro-foundations of digital capabilities, as facilitated by digital technologies, assist pivoting; and (2) the process from key activities during pivoting to second-order themes that represent micro-foundations to digital (dynamic) capabilities for pivoting in turbulent environments. The study highlights the importance of digital pivoting for businesses in the UK Southeast that have many aspirations for growth and innovation, whilst striving to address multiple challenges including digital divide and literacy, inflation and cost of living crisis, as well as supply chain issues.

Genomic epidemiology of syphilis in England: a population-based study

Syphilis is a sexually transmitted bacterial infection caused by Treponema pallidum subspecies pallidum. Since 2012, syphilis rates have risen dramatically in many high-income countries, including England. Although this increase in syphilis prevalence is known to be associated with high-risk sexual activity in gay, bisexual, and other men who have sex with men (GBMSM), cases are rising in heterosexual men and women. The transmission dynamics within and between sexual networks of GBMSM and heterosexual people are not well understood. We aimed to investigate if whole genome sequencing could be used to supplement or enhance epidemiological insights around syphilis transmission. We linked national patient demographic, geospatial, and behavioural metadata to whole T pallidum genome sequences previously generated from patient samples collected from across England between Jan 1, 2012, and Oct 31, 2018, and performed detailed phylogenomic analyses. Of 497 English samples submitted for sequencing, we recovered 240 genomes (198 from the UK Health Security Agency reference laboratory and 42 from other laboratories). Three duplicate samples (same patient and collection date) were included in the main phylogenies, but removed from further analyses of English populations, leaving 237 genomes. 220 (92·8%) of 237 samples were from men, nine (3·8%) were from women, and eight (3·4%) were of unknown gender. Samples were mostly from London (n=118 [49·8%]), followed by southeast England (n=29 [12·2%]), northeast England (n=24 [10·1%]), and southwest England (n=15 [6·3%]). 180 (76·0%) of 237 genomes came from GBMSM, compared with 25 (10·5%) from those identifying as men who have sex with women, 15 (6·3%) from men with unrecorded sexual orientation, nine (3·8%) from those identifying as women who have sex with men, and eight (3·4%) from people of unknown gender and sexual orientation. Phylogenomic analysis and clustering revealed two dominant T pallidum sublineages in England. Sublineage 1 was found throughout England and across all patient groups, whereas sublineage 14 occurred predominantly in GBMSM older than 34 years and was absent from samples sequenced from the north of England. These different spatiotemporal trends, linked to demography or behaviour in the dominant sublineages, suggest they represent different sexual networks. By focusing on different regions of England we were able to distinguish a local heterosexual transmission cluster from a background of transmission in GBMSM. These findings show that, despite extremely close genetic relationships between T pallidum genomes globally, genomics can still be used to identify putative transmission clusters for epidemiological follow-up. This could be of value for deconvoluting putative outbreaks and for informing public health interventions. Wellcome funding to the Sanger Institute, UK Research and Innovation, National Institute for Health and Care Research, European and Developing Countries Clinical Trials Partnership, and UK Health Security Agency.

Preliminary evidence of Drosophila suzukii parasitism in Southeast England.

Controlling the invasive fruit pest, Drosophila suzukii, relies on a range of complimentary pest management approaches. However, increasing external costs (e.g., labour, exclusion mesh and fuel), are limiting the ability to control the pest via non-chemical means. Extant UK parasitoids could be exploited for the suppression of D. suzukii populations, but there is currently a lack of knowledge of the UK species utilising D. suzukii as a host or their lifecycle requirements. Between 2017 and 2020, we identified parasitoids developing in D. suzukii, in Southeast England.Sentinel traps, containing laboratory reared D. suzukii larvae/pupae in fruit, were deployed within the vicinity of commercial crops and semi-natural areas. Six generalist parasitoid species were recovered from D. suzukii sentinel traps. These included two species of larval parasitoids (Leptopilina heterotoma Thomson (Hymenoptera: Figitidae) and Asobara tabida (Nees) (Hymenoptera: Braconidae) and four pupal parasitoids (Pachycrepoideus vindemiae (Rondani) (Hymenoptera: Pteromalidae), Spalangia erythromera (Forster) (Hymenoptera: Pteromalidae), Trichopria modesta (Ratzeburg, 1848) and T. prema Nixon (both Hymenoptera: Diapriidae)).The performance of the first four species as D. suzukii parasitoids was further tested in the laboratory and then in the field to assess rates of parasitism. Pachycrepoideus vindemiae was the most abundant species recovered from field collections and had in increasing rate of population rate in the laboratory. Other species were not successful at parasitising D. suzukii. In the field, adult D. suzukii emergence from sentinel traps was reduced by ~ 21% where parasitoids could access D. suzukii larvae and pupae.Parasitoids of D. suzukii are understudied in the UK, and this research indicates where future efforts could be made in understanding the interaction between host and parasitoid and the opportunities to exploit extant parasitoids for the control of D. suzukii. We also evaluate the prospects for classical and augmented control and discuss how they may fit with current regional integrated pest management options.

The search for linguistically coherent accents

Abstract Linguistic research refers to many related accents in Southeast England: Standard Southern British English (SSBE), Received Pronunciation (RP), Estuary English (EE), Cockney and Multicultural London English (MLE). However, there is inconsistency and imprecision in the demarcation of these accents based on linguistic and social factors. This paper delineates accents in Southeast England based on patterns of linguistic co-variation which we then relate to social predictors. We applied functional Principal Component Analysis to F1 and F2 measurements for diphthongs extracted from wordlist and passage productions for 193 young, south-eastern speakers. Principal Components were entered into a clustering analysis that identified patterns of linguistic co-occurrence. Three clusters emerge, broadly aligning with SSBE, MLE and EE for both linguistic and social factors. We illustrate the linguistic centre of gravity of the three diphthong systems for use as reference points in future research, and we discuss the need to make explicit how accents are defined.

Strongyle egg reappearance periods following moxidectin treatment in horses in southeast England

Strongyle egg reappearance periods following moxidectin treatment in horses in southeast England

‘What Do You Mean You Haven't Got Tools?’

Abstract Itinerant boat dwellers (boaters) in London and South East England speak about many internal divisions within the community. ‘Dirty boaters’ are contrasted with ‘shiny boaters’; ‘yuppies’ and ‘hipsters’ are contrasted ‘oldtimers,’ ‘crusties’ or ‘pirates’. For many, be they boaters, outsiders or other writers, these distinctions have something to do with class background. However, my ethnographic research with the boaters shows that, although class background can be thought to be a marker of how hard or easy one may find it to become a boater, the internal divisions that are found on the waterways have more to do with processes of socialisation. What matter (and what divide boaters) are the willingness and ability, or lack therein, to join a community of practice on the waterways and to learn the skills and ethics that are of value to boaters in their community of mutual support.

“Weird duality”: learning from the experiences of students in university peer support roles during the COVID-19 pandemic

Objectives: To explore university student peer supporter experiences in the pandemic context and with a specific focus on student mental health. Participants: The sample comprised 13 students from various peer support programs, providing academic, social and/or emotional support at a South-East England university. Methods: A two-phase qualitative design involved individual interviews and focus groups, followed by participant validation with a subset of participants. Results: Peer supporters identified an increased need peri-pandemic for mental health support. The accessibility was aided by students perceiving peer supporters to be approachable, but was undermined by concerns about peers’ credibility. Supporter-supportee relationships were characterized by intimacy and mutuality, which were seen as conducive to authenticity, but caused challenges with respect to boundaries. Conclusions: Peer support is a complex activity, characterized by a sense of multiplicity and mutuality. Responsive supervision and dedicated training are necessary to manage these complexities amidst elevated student mental health needs.

Our approach to developing communities of practice to foster research capacities for the adult social care workforce.

Efforts to build and foster adult social care research in England have historically encountered more challenges to its growth and expansion compared with health research, with a sector facing significant barriers in facilitating research activity due to a lack of resourcing, poor valuation or understanding of the profile of social care research. The landscape for supporting research in adult social care has been rather bleak, but in recent years there has been recognition of the need to foster a research community. The National Institute for Health and Care Research in England have committed to investing in social care research capacity by funding six adult social care partnerships, with one based in Southeast England. Three large online networking events were held in the first year of the project to engage managers and practitioners from the local authority and from the wider adult social care sector. These took place in July and November 2021, with a last event in March 2022. Two COPs were identified, following an ordering and thematising process of feedback from the networking events, of: (a) Supporting people with complex needs throughout the lifespan, and (b) Enhancing, diversifying and sustaining the social care workforce. Whilst it would be premature to identify their long-term impacts, through the facilitation of 20 COP meetings held so far, alongside the engagement platforms and enrichment resources, these have provided a space for regular communication in the sector, knowledge sharing and networking between COP members. The COP framework offers a collaborative approach to initiating research from the grass-roots level in adult social care. This paper focuses on how the COP model offers great promise for knowledge-exchange providing a forum to generate and disseminate knowledge around social care in our two COP domains.

SP2.1 The Impact of Cholecystectomy on The Symptom Relief and Quality of Life of Patients with Gallbladder Dysmotility

Abstract Aims The aim of this study was to demonstrate the impact of laparoscopic cholecystectomy on the physical and mental health of patients with gallbladder dysmotility. Methods Retrospective data was collected from patients who had undergone a Hepatobiliary Iminoacetic Acid (HIDA) scan between June 2012 and June 2022 in a District General Hospital in South East England. Patients diagnosed with gallbladder dysmotility were then contacted and asked to participate in a telephone interview regarding their symptoms. Their health-related quality of life was measured using the HRQoL SF-12 v2 questionnaire. Differences in the resolution of symptoms between those that had undergone a cholecystectomy and those who did not, were assessed using a chi square test. The two groups were then compared using the student t-test to assess statistically significant differences. Results 94% (n=31/33) of participants in the non-cholecystectomy group demonstrated persistent biliary pain symptoms as opposed to the 6% (n=2/33) in the cholecystectomy group. A statistically significant improvement in five out of the eight domains of the HRQoL SF-12 questionnaire was demonstrated. These domains include PCS (physical component summary), MCS (mental component summary), mental health, general health and bodily pain. Conclusion The results of our retrospective analysis demonstrate an improvement in both the physical and health-related quality of life symptoms in patients who underwent laparoscopic cholecystectomy. These findings support the use of laparoscopic cholecystectomy as an effective method for managing gallbladder dysmotility.