Southeast Asian Countries Research Articles

Lactiplantibacillus plantarum causes the abnormal fermentation of bacterial cellulose by Komagataeibacter nataicola during nata de coco production

Nata de coco, chemically known as bacterial cellulose (BC), is mostly manufactured in Southeast Asian countries and Hainan, China. Failures happened frequently due to the open fermentation system of nata de coco, especially in winter and spring. This study investigated the differences between normal and abnormal fermentation processes in a nata de coco manufacturing factory. Results revealed significant variations in microbial composition and metabolite profiles between abnormal and normal fermentation batches. Lactiplantibacillus plantarum GPb4103 was further isolated and screened from the abnormal fermentation broth to investigate its potential inhibitory effect on BC synthesis of Komagataeibacter nataicola JY6211. Although co-culturing the strain JY6211 and L. plantarum GPb4103 resulted in synergistic growth, BC yield decreased by up to 53%. The KEGG pathway analysis of differential metabolites showed that the GPb4103 hindered BC synthesis of the JY6211 by altering accumulation of metabolites in the fermentation broth through metabolic pathways. This study provides new insights into how specific microbes could affect BC synthesis of K. nataicola during nata de coco production, thereby illuminating challenges faced in commercial BC production, such as inconsistent products quality and problematic production processes.

The Role of Secure Property Rights in Driving Economic Growth: A Review of Recent Evidence

This paper aims to briefly explain the factors contributing to economic growth, particularly emerging and developing economies, emphasizing the impacts of secure property rights. Tangible and intangible assets such as land and minerals, patents and copyrights offer the investors legal recognition that enhances investment, inventive activities and efficient market exchange. The review demonstrates how property rights reforms have positively impacted agricultural yields, credit facilities, and FDI in sub-Saharan Africa, Southeast Asia and Latin American countries. The paper also focuses on the impact of intellectual property rights on technological advancement, especially in knowledge-based societies. While the previous shows that there are gains in reforms in property rights, it has to be stated that there are still hurdles in the implementation of property rights reforms for the benefit of the more significant population due to the following: ? Finally, the paper reiterates the importance of efficient and precise laws and policies that will enhance the efficiency of the property rights to enhance the economic returns.

PfHDAC1 is an essential regulator of P. falciparum asexual proliferation and host cell invasion genes with a dynamic genomic occupancy responsive to artemisinin stress.

Malaria is a major public health problem, with the parasite Plasmodium falciparum causing most of the malaria-associated mortality. It is spread by the bite of infected mosquitoes and results in symptoms such as cyclic fever, chills, and headache. However, if left untreated, it can quickly progress to a more severe and life-threatening form. The World Health Organization currently recommends the use of artemisinin combination therapy, and it has worked as a gold standard for many years. Unfortunately, certain countries in southeast Asia and Africa, burdened with a high prevalence of malaria, have reported cases of drug-resistant infections. One of the major problems in controlling malaria is the emergence of artemisinin resistance. Population genomic studies have identified mutations in the Kelch13 gene as a molecular marker for artemisinin resistance. However, several reports thereafter indicated that Kelch13 is not the main mediator but rather hinted at transcriptional deregulation as a major determinant of drug resistance. Earlier, we identified PfGCN5 as a global regulator of stress-responsive genes, which are known to play a central role in artemisinin resistance generation. In this study, we have identified PfHDAC1, a histone deacetylase as a cell cycle regulator, playing an important role in artemisinin resistance generation. Taken together, our study identified key transcriptional regulators that play an important role in artemisinin resistance generation.

Prognostic model of in-hospital ischemic stroke mortality based on an electronic health record cohort in Indonesia.

Stroke patients rarely have satisfactory survival, which worsens further if comorbidities develop in such patients. Limited data availability from Southeast Asian countries, especially Indonesia, has impeded the disentanglement of post-stroke mortality determinants. This study aimed to investigate predictors of in-hospital mortality in patients with ischemic stroke (IS). This retrospective observational study used IS medical records from the National Brain Centre Hospital, Jakarta, Indonesia. A theoretically driven Cox's regression and Fine-Gray models were established by controlling for age and sex to calculate the hazard ratio of each plausible risk factor for predicting in-hospital stroke mortality and addressing competing risks if they existed. This study finally included 3,278 patients with IS, 917 (28%) of whom had cardiovascular disease and 376 (11.5%) suffered renal disease. Bivariate exploratory analysis revealed lower blood levels of triglycerides, low density lipoprotein, and total cholesterol associated with in-hospital-stroke mortality. The average age of patients with post-stroke mortality was 64.06 ± 11.32 years, with a mean body mass index (BMI) of 23.77 kg/m2 and a median Glasgow Coma Scale (GCS) score of 12 and an IQR of 5. Cardiovascular disease was significantly associated with IS mortality risk. NIHSS score at admission (hazard ratio [HR] = 1.04; 95% confidence interval [CI]: 1.00-1.07), male sex (HR = 1.51[1.01-2.26] and uric acid level (HR = 1.02 [1.00-1.03]) predicted survivability. Comorbidities, such as cardiovascular disease (HR = 2.16 [1.37-3.40], pneumonia (HR = 2.43 [1.42-4.15] and sepsis (HR = 2.07 [1.09-3.94, had higher hazards for post-stroke mortality. Contrarily, the factors contributing to a lower hazard of mortality were BMI (HR = 0.94 [0.89-0.99]) and GCS (HReye = 0.66 [0.48-0.89]. In summary, our study reported that male sex, NIHSS, uric acid level, cardiovascular diseases, pneumonia, sepsis. BMI, and GCS on admission were strong determinants of in-hospital mortality in patients with IS.

Past and future joint return period of precipitation extremes over South Asia and Southeast Asia

Climate change is one of the major reasons for the increased intensity and frequency of precipitation extremes in tropical regions. This will have a significant impact on underdeveloped countries in South Asia and Southeast Asia. Therefore, this study analyzes changes in spatiotemporal patterns and the joint behavior of precipitation extremes across South Asian and Southeast Asian countries for the historical period (1975 to 2014) and future periods (2021–2060 (F1) and 2061–2100 (F2)). This study develops bias-corrected precipitation data and ranks General Circulation Models (GCMs) using the Empirical Quantile Mapping method and TOPSIS method, respectively. A multi-model ensemble of precipitation extremes is created using the top five GCMs. The Mann Kendall test is used to analyze trends in precipitation extremes. Joint probabilistic analysis is also conducted for different combinations of ETCCDI precipitation-based indices using Archimedes and Elliptical copulas. The results of the trend analysis indicate significant positive trends for R20mm (19.26%), R95pTOT (18.40%), Rx5Day (11.53%), and CWD (10.46%), while CDD (5.07%) shows a significant negative trend across the study area during historical period (1975–2014). The results of R20mm, R95pTOT, and Rx5Day under SSP585 shows almost 19 to 39% of area comes under significant positive trend during the F1 period. This becomes more evident in F2, with trends under SSP585 rising between 32% and 61%. The high-emissions scenario SSP585 reveals an increase in these positive trends compared to SSP126 in both the future periods (F1 and F2). These results indicating a noticeable rise in extreme precipitation events. The analysis of changes in the joint return period of precipitation extremes indicates that the South Peninsular India, North East India, West Central India and Central Northeast India, as well as most parts of Southeast Asian countries, will experience very heavy intensify precipitations in the future. In addition, persistent co-occurrence of dry and wet conditions will be observed in Pakistan, North West India, and Central Northeast India. This study provides useful information on the distribution of precipitation extremes in different regions of the study area.

Evolutionary transition of hypervirulent Klebsiella pneumoniae to multidrug-resistant hypervirulent Klebsiella pneumoniae: Indian experience

An emerging pathotype of Klebsiella pneumoniae, initially identified in Southeast Asian countries, has now spread to multiple countries, including India. These convergent strains, carrying both resistance and virulence determinants, are classified as multidrug-resistant Hypervirulent Klebsiella pneumoniae (MDR-HvKp). Since the initial reports, there has been a concerning surge in infections caused by this pathotype globally. In this context, we aim to shed light on the evolutionary changes that have taken place in this relatively novel pathotype. Understanding these changes is crucial for devising diagnosis and targeted intervention strategies to mitigate the spread of MDR-HvKp infections.

Religious Movements in Some Southeast Asian Countries at The Beginning of the 20th Century

Southeast Asia is an economic and culturally rich hub, one of the cradles of human history where diverse and vibrant cultures converge. Particularly, the religious landscape in Southeast Asian countries at the beginning of the 20th century vividly manifested in the movements against colonialism and imperialistic invasions by various nations. Class conflicts within society, coupled with unresolved contradictions, and the hardships of life in a tumultuous social context, led people to turn to religion. The study analyzes the characteristics of religious movements in some Southeast Asian countries in the early 20th century, thereby drawing some conclusions about religious movements in Southeast Asian countries in the early 20th century. In the process of approaching the problem, the author uses research methods such as text analysis, logic-history, unity between synchronic and diachronic perspectives, and analysis-synthesis... These research methods are applied by the author in a consistent dialectical manner to provide a comprehensive and specific research approach suitable to the current task. Developing humanistic values in religion will play an important role in preventing all personality corruption and helping people adjust their behavior and social relationships, contributing to stabilizing social order and safety. Religious movements in Southeast Asian countries in the early twentieth century contributed to spreading noble humanistic values in religion.

Sea cucumber significance: Drying techniques and India's comprehensive status.

Sea cucumbers, members of the echinoderm class Holothuroidea, are marine invertebrates with ecological significance and substantial commercial value. With approximately 1700 species, these organisms contribute to marine ecosystems through nutrient cycling and face various threats, including overfishing and habitat loss. Despite their importance, they are extensively exploited for diverse applications, from seafood to pharmaceuticals. This study investigates sea cucumbers' nutritional profile and bioactive elements, emphasizing their role as sources of essential compounds with potential health benefits. The demand for sea cucumbers, especially in dried form, is significant, prompting exploration into various drying techniques. Examining the global trade in sea cucumbers highlights their economic importance and the conservation challenges they face. Conservation efforts, such as awareness campaigns and international collaboration, are evaluated as essential steps in combating illicit trade and promoting the sustainable stewardship of sea cucumber populations. PRACTICAL APPLICATION: Around 1700 species of sea cucumbers were identified as vital ecological scavengers in the Holothuroidea class. High commercial value due to their health benefits, particularly their demonstrated inhibitory effect against various types of cancer. "Beche-de-mer" holds a 90% market share and is regarded as a luxury food item in Southeast Asian countries. Due to overexploitation, the species isclassified as Schedule I under the Wildlife Protection Act (WPA) in India, prompting the implementation of a blanket ban on their harvesting to ensure its conservation.

Vietnam’s liquefied natural gas demand—potential to import liquefied natural gas from the USA

Abstract Vietnam, a dynamic and rapidly developing country in Southeast Asia, is experiencing a surge in energy demand due to its booming economy and growing population. However, with the strong commitment of the Vietnamese government to achieve net-zero emissions by 2050 at COP 26, Vietnam needs to implement robust measures to reduce greenhouse gas emissions, with energy transition as a top priority. To meet this growing energy demand and minimize greenhouse gas emissions in the energy sector, Vietnam is turning its attention to liquefied natural gas (LNG), an environmentally friendly and versatile energy source. With the USA emerging as a major global exporter of LNG based on the shale gas revolution, Vietnam has recognized the potential to import LNG from the USA to meet its energy needs in a sustainable manner. The purpose of this article is to analyse the reasons why Vietnam has prospects for importing LNG from the USA.

Ocular Brugia pahangi Filariasis Complicated by Severe Macular Damage in Thailand: Case Report and Literature Review.

Extralymphatic filariasis caused by filaria of zoonotic origins has been frequently reported in Thailand over recent years. Here, we report the first case of ocular filariasis in a 7.5-year-old Thai boy who initially presented with progressive conjunctival redness and blurred vision in his right eye. A small, slender, coiled worm was found and surgically removed from the right anterior chamber. Histopathological examination illustrated predominant eosinophilic inflammation surrounding the parasite, which showed smooth and thin cuticle, prominent lateral chords, flat and broad muscle cells, one intestine, and two reproductive tubes with unsegmented ova, typically characteristic of a female adult Brugia filarial nematode. The parasite was also molecularly identified as B. pahangi, based on mitochondrial cytochrome c oxidase subunit I sequence analysis. The patient was then empirically prescribed albendazole, systemic prednisolone, and topical methylprednisolone. Unfortunately, his vision did not recover after 2 months due to severe maculopathy, most likely resulting from parasitic infestation and subsequent vitreous inflammation. To the best of our knowledge, this is the first case of ocular infestation by B. pahangi with visual complications that occurred outside a filariasis-endemic area of Thailand. Furthermore, this report provides clinical data on preceding cases of B. pahangi filariasis formally reported in southeast Asian countries, including Thailand and Malaysia, which facilitate a better understanding of the epidemiology of this sporadic zoonotic infection for effective disease elimination.

Migration health ethics in Southeast Asia: a scoping review

Background Asia hosts the second-largest international migrant population in the world. In Southeast Asia (SEA), key types of migration are labour migration, forced migration, and environmental migration. This scoping review seeks to identify key themes and gaps in current research on the ethics of healthcare for mobile and marginalised populations in SEA, and the ethics of research involving these populations. Methods We performed a scoping review using three broad concepts: population (stateless population, migrants, refugees, asylum seekers, internally displaced people), issues (healthcare and ethics), and context (11 countries in SEA). Three databases (PubMed, CINAHL, and Web of Science) were searched from 2000 until May 2023 over a period of four months (February 2023 to May 2023). Other relevant publications were identified through citation searches, and six bioethics journals were hand searched. All searches were conducted in English, and relevant publications were screened against the inclusion and exclusion criteria. Data were subsequently imported into NVivo 14, and thematic analysis was conducted. Results We identified 18 papers with substantial bioethical analysis. Ethical concepts that guide the analysis were ‘capability, agency, dignity’, ‘vulnerability’, ‘precarity, complicity, and structural violence’ (n=7). Ethical issues were discussed from the perspective of research ethics (n=9), clinical ethics (n=1) and public health ethics (n=1). All publications are from researchers based in Singapore, Thailand, and Malaysia. Research gaps identified include the need for more research involving migrant children, research from migrant-sending countries, studies on quality of migrant healthcare, participatory health research, and research with internal migrants. Conclusions More empirical research is necessary to better understand the ethical issues that exist in the domains of research, clinical care, and public health. Critical examination of the interplay between migration, health and ethics with consideration of the diverse factors and contexts involved is crucial for the advancement of migration health ethics in SEA.

Can Entomophagy be a Good Option for Nutrition and Food Security?

As the population increases, so does the demand for food and resources. Insects are rich in proteins, unsaturated fats and low in carbohydrates. They contain all the essential minerals and vitamins like iron, zinc, calcium, potassium, sodium, copper, riboflavin, biotin, and vitamin B9. Food and Agricultural Organization (FAO), estimated that the world need to increase its food production to feed a worldwide population of more than nine billion by the year 2050. Insects offer so much potential as an alternative food source to meet this need. More than two billion people including various ethnic communities around the world practice entomophagy and consume more than 2000 species of edible insects. Southeast Asian countries and African countries are one of the biggest consumers of edible insects. Due to its health and nutritional benefits, there is an increased demand and interest in European and American countries. Government policymakers, entrepreneurs, educationists, and chefs worldwide are exploring and promoting edible insects. Promoting novel insect-based food that is made of insects or insect ingredients such as insect flour, and insect protein powder could increase consumers and consumption. This review highlights insects as an alternative protein source for future food production. Insects like black soldier flies are used as insect feed for animals in poultry, pigs, and cows and are high in demand. Insects produce significantly less greenhouse gas emissions compared to other livestock. Edible insect farming and entomophagy present an important and sustainable opportunity for the future of food. This could also help generate employment for the rural women and youths as an alternate source of livelihood. Entomophagy has the potential to solve the world’s food hunger and at the same time save the environment.

Sustainable strategic planning and management influence on sustainable performance: findings from halal culinary MSMEs in Southeast Asia

Purpose This study aims to evaluate the impact of sustainable strategic planning and management (SSPM) on sustainable performance (ecological, social and economic) among micro, small and medium enterprises (MSME) in the culinary sector in Southeast Asia (SEA). Design/methodology/approach This study used a quantitative approach surveying 300 halal-certified MSMS culinary businesses in the SEA region. Data were gathered using an online survey platform and analyzed using the partial least squares structural equation modeling technique. Findings Green management (GRM), digital transformation management (DTM) and Halal Business Management (HBM) exert a significant influence on SSPM. Furthermore, SSPM positively influences the sampled halal culinary MSMEs’ ecological, social and economic performances in SEA. The study also reveals that GRM, DTM and HBM positively influence Islamic ethics compliance and good governance. Research limitations/implications This study sheds light on the often-ignored MSME business in the halal culinary sector in SEA. Examining sustainable and strategic planning synergy strengthens the development of a comprehensive framework for SSPM and could encourage more MSMEs to practice sustainable business operations. Moreover, the research also underlines the urgent need to harmonize halal standards in the SEA region. The approach would intensify multilateral support for economic growth and halal trade between SEA countries and beyond. Originality/value This study addresses the research gap in the strategic and sustainable management of halal culinary MSMEs within the developing and vast SEA economic region. This research is among the few, if not the first, that combines the GRM, DTM and HBM influence on SSPM and examines the impact on sustainable, ethical and good governance performances. The insights derived from this study contribute to formulating robust, sustainable policies, fostering avenues for sustainable initiatives and enhancing regional and global cooperation for a sustainable future.

Ocular filariasis in the form of a conjunctival granuloma – A rare case report from non-endemic part of India

Filariasis, a predominantly lymphatic disease can rarely have ocular involvement in endemic as well as a few non-endemic zones of the Indian subcontinent. It has also been reported from countries of South East Asia. In India, Wuchereria bancrofti and Brugia malayi are the nematodes causing filariais. Ocular involvement can happen in a wide spectrum, involving lacrimal glands, conjunctiva and fornices, cornea, anterior chamber, and vitreous cavity. We report a case of adult filarial worm (B. malayi) inside a conjunctival granuloma in a lady hailing from a rural, non-endemic part of the country. The lady presented with a short history of ocular irritation and redness. Clinical examination revealed a small granuloma-like lesion with surrounding inflammation over the conjunctiva. The rest of the anterior segment as well as the posterior segment was fairly within normal limits. The history as well as clinical examination was not supportive of a parasitic infestation, leading the doctors to treat the lesion as an allergic disease. However, the lesion remained unresolved, and surgical excision was undertaken. On surgical intervention, a live worm was spotted inside the lesion. Parasitological evaluation of the worm was confirmatory of adult filaria (B. malayi). The patient responded to a combination therapy of oral diethylcarbamazine and albendazole.

75 years’ journey of malaria publications in English: what and where?

Malaria has inflicted serious morbidity and mortality across the globe. The major brunt of the disease has been on African, South-East Asian and South American countries. Proportionally, malaria has attracted global research priorities and this is evident from the number of publications related to malaria from across the globe, irrespective of its endemicity. However, formal and exhaustive analyses of these ‘malaria publications’ are rarely reported. The systematic review and secondary data analyses were done to retrieve information on what has been published on malaria, where is it published, and which countries are major contributors to malaria research.The study presents malaria publications from 1945 to 2020 retrieved using three databases: Web of Science™, Embase® and Scopus®. Exported data were examined to determine the number of publications over time, their subject areas, contributions from various countries/organizations, and top publishing journals.The total number of published records on malaria ranged from 90,282 to 112,698 (due to three different databases). Based on the number of publications, USA, UK, France, and India were identified as the top four countries. Malaria Journal, American Journal of Tropical Medicine & Hygiene, and PLoS One were the most preferred journals, whereas the University of London (Institutions other than LSHTM), the National Institute of Health, the London School of Hygiene and Tropical Medicine, and the University of Oxford appeared to be the top contributing organization.A disproportional contribution to malaria research was observed with non-malaria endemic countries making the largest contribution. Databases differed in their output format and needed standardization to make the outputs comparable across databases.

Pathogenic germline variants among Thai patients with colorectal cancer: A study in Genomics Thailand Project.

e22534 Background: Germline variant testing in colorectal cancer (CRC) patients (pts) has been applied in many countries. Limited data is known regarding germline CRC prevalence in Thailand and other low to middle-income countries in Southeast Asia. Identifying the variants in different ethnicities may show the variety in frequency of the pathogenic germline variants (PGVs) and their relationship with clinical characteristics. Our study reports on the distribution of PGVs and their clinical findings in Thai CRC pts. Methods: We use the germline testing results from the Genomics Thailand Project during 2020-2023, which performed next-generation sequencing on 50,000 pts in 5 disease groups. CRC pts in our institution with a potential risk of carrying PGVs were sent to a geneticist to obtain a family history prior to undergoing germline testing with 25-96 cancer-predisposing genes. Pts with complete pedigree data and germline testing results were enrolled in our retrospective cohort to analyze the variants and clinical findings from chart reviews. Descriptive statistics, the Cox proportion hazards model, and the Kaplan-Meier method were used to evaluate the results. Results: We included 137 CRC pts with a mean age of 47 years at diagnosis, and 58.4% were male. Of these, 38/137 (27.8%) pts were identified as pathogenic/likely pathogenic(P/LP). 26/38 (68.4%) were pathogenic Lynch syndrome (LS), 16 (42.1%) MLH1, 6 (15.8%) MSH2, 2 (5.3%) MSH6, and 2 (5.3%) PMS2. Among pathogenic non-LS, the most frequent variant was 4 (10.5%) APC, followed by 3 (7.9%) ATM, 2 (5.3%) BRCA2, 1 (2.6%) PTEN, 1 (2.6%) BARD1, and 1 (2.6%) monoallelic MUTYH. The LS group was significantly associated with a family history of CRC (p < 0.001), endometrial cancer (p = 0.001), and a synchronous/metachronous CRC (p = 0.003) compared to the non-PGVs group. Likewise, the presence of CRC in a first-degree relative (p = 0.025), more than one CRC pts in the family (p = 0.027), or early onset CRC (p = 0.012) in a first-degree relative was also significantly higher in the pathogenic non-LS group compared to the non-PGVs group. CRC pts who had more than one primary cancer in a lifetime were not significant in the LS or non-LS group compared to the non-PGVs group. At a median follow-up time of 60 (range 7-453) months, Pts in the PGVs group tended to have a shorter median time from the first CRC diagnosis to a second event defined as any of metachronous/synchronous CRC, recurrent CRC, or second cancer in a different organ compared to the non-PGVs group (135 vs. 228 months, p = 0.11). Conclusions: 27.8% pts in our cohort carried P/LP germline variants. The PGVs group was associated with a shorter time to the second event and a higher rate of familial cancer. Our study supports the benefits of genetic cancer screening. [Table: see text]

Intercontinental Comparison of Immunohistochemical Subtypes Among Individuals With Breast Cancer in South-East Asia and South America: A Scoping Systematic Review and Meta-Analysis of Observational Studies.

Breast cancer (BC) remains a significant global concern, particularly among developing countries in South-East Asia (SEA) and South America (SA). The socioeconomic burdens of oncologic care in those countries were often originated from limited accessibility on attainable therapeutic options and reliability on identifying essential information of cancer cells, i.e., immunohistochemical (IHC) subtyping to determine suitable approaches. The triple-negative breast cancer (TNBC) is among the most aggressive category in breast malignancy, therefore, requiring more specific molecular pathway blocking to exhaust the cells. However, large-scale epidemiological investigation on its rate among BC remains unavailable to date. This study aimed to describe the prevalence of TNBC in the SEA and SA continents since it may guide the future direction of oncologic research and trials. This review focuses on observational studies from the SEA and SA continents from the last decade. Each study represents its country or cities, period of observation, population size, and the TNBC-BC rate as the main outcomes. Therefore, we may also limit the reporting bias originated from same-patient data on the specific occasions. The analysis will be derived to SEA-SA comparison, plus SEA/SA-specific session as processed in Comprehensive Meta-Analysis (CMA) version 3.0. The statistical analysis will be performed in random effects model (REM) within 95% confidence interval (CI). From 46 studies included in the final analysis with a total enlisted population of 34,346 unique individuals with BC, the TNBC rate was higher in the SEA compared to the SA region (19.3% vs. 15.7%; P < 0.05 in 95% CI), with the highest prevalence observed in Vietnam (22.4%) and Peru (17.8%), if it was restricted on countries with two or more studies. Interestingly, both Laos and Argentina possessed significant differences compared to other countries within their respective continents, with the highest and lowest TNBC rates (P < 0.05). The IHC characteristics in SEA differ from those in the SA continent as mainly represented by TNBC prevalence, possibly shaping the course of future trials in the respective region based on IHC expressivity status.

What Do We Know About the Influence of Believers' Religiosity on Happiness and Gratitude? - A Perspective for Clinical Practice.

The recognition of religion's significance in mental health has led to several scientific advances in diagnosis or treatment. In contrast, Vietnam is a multi-religious Southeast Asian country with a large number of believers, but there is almost no research addressing the impact of religiosity among Vietnamese believers on mental health concerns such as depression, happiness, and gratitude. Our cross-sectional study was focused on Vietnamese believers (N = 374), surveyed directly at different religious facilities in Vietnam. The present study was evaluated utilizing the partial least squares-structural equation modeling (PLS-SEM) methodology. The primary findings of the study indicate that (i) age was found to positively moderate the association between intrinsic religiosity and gratitude (β = 0.191, 95% CI [0.116, 0.277], p < 0.001); (ii) Intrinsic religiosity has a positive influence on depression-happiness scale (β = 0.276, 95% CI [0.168, 0.373], p < 0.001) and gratitude (β = 0.337, 95% CI [0.205, 0.466], p < 0.001); Moreover, (iii) gratitude has a positive influence on depression-happiness scale (β = 0.381, 95% CI [0.280, 0.491], p < 0.001); Finally, (iv) the study revealed that gratitude mediates the relationship between intrinsic religiosity and depression-happiness scale (β = 0.128, 95% CI [0.071, 0.197], p < 0.001). The findings of this study suggest that gratitude could potentially play a significant role in comprehending the association between religiosity and the levels of depression and happiness experienced by religious individuals in Vietnam.

Anthelmintic activity and pathophysiological effect of anthelmintic drugs against carcinogenic liver fluke, Opisthorchis viverrini.

Human liver fluke, Opisthorchis viverrini poses a significant risk for development of cholangiocarcinoma (CCA) in Thailand, primarily attributed to consumption of undercooked cyprinoid fishes. The current use of anthelmintic drug treatment such as praziquantel (PZQ), as the main therapeutic agent against O. viverrini. There is a need to explore the efficacy of alternative anthelmintic drugs for O. viverrini treatment. This study aimed to assess the efficacy of anthelmintic drugs, which are commonly use in endemic areas of Southeast Asian countries; PZQ, albendazole (AL), niclosamide (NI), and mebendazole (ME) at concentrations of 600, 400, 500, and 500 mg/ml. The study included a negative and positive control group treated with roswell park memorial institute (RPMI) and PZQ. Reactive oxygen species (ROS) levels, indicative of oxidative stress, were quantified using 2',7'-dichlorofluorescein diacetate staining. Morphological changes were observed using scanning electron microscopy. Furthermore, motility assessments were conducted at various time points (0, 5, 30 minutes, 1, 3, 6, 12, and 24 hours), calculating relative motility (RM) and survival index (SI). The results revealed a significant increase of ROS levels with the intensity and corrected total worm fluorescence (CTWF) mostly observed in order of PZQ, followed by NI, ME, and AL, respectively. Morphological damage was presented the tegumental swelling, papillae changes, and disruption of microvilli (Mv), particularly in the group treated with the most effective anthelmintics PZQ, NI, ME, and AL, while negative control group did not exhibit such alterations. Also, the most efficacy for suppressing the motility of adult worms were displayed in PZQ treatment group, followed by NI, ME, and AL, respectively. Overall, first novel findings suggest that apart from NI, ME, and AL demonstrate potential as alternative therapeutic options for O. viverrini infection. Furthermore, animal model is needed to investigate the efficacy of NI, ME, and AL compare with standard treatment.

Disparities in incidence and mortality of hematologic cancers in Southeast Asia: A 2020 analysis.

e23291 Background: Hematologic cancers (HCs) in Southeast Asia (SEA), a diverse population of over 680 million, are still understudied. Data from the 2020 Global Cancer Observatory (GCO) was used to estimate the incidence and mortality of HCs in the region to provide direction for effective disease control and improve population outcomes. Methods: The International Agency for Research on Cancer’s publicly available GCO data aggregates global cancer incidence and mortality. We report cumulative incidence rate (CIR) and cumulative mortality rate (CMR) defined per 100,000 people, and weighted average age-standardized incidence rate (ASIR) and age-standardized mortality rate (ASMR) in 2020. Data for Hodgkin Lymphoma (HL), Non-Hodgkin's Lymphoma (NHL), Leukemia, and Multiple Myeloma (MM) in the world, in SEA, and in the 11 individual SEA countries are presented. Results: The table presents CIR, ASIR, CMR, and ASMR of hematologic cancers in SEA compared to overall global data. CIR, ASIR, CMR, and ASMR were higher for males than females in SEA. For NHL, CIR was highest in Singapore (18.8), Thailand (10.2), and Brunei (9.6) and lowest in Myanmar &amp; Cambodia (3.6), and Timor-Leste (2.7). ASIR trends were parallel albeit differences were smaller. CMR was highest in Singapore (6.2) and Thailand (5.9) and lowest in Timor-Leste (1.5). ASMR was highest in Brunei (4.5) and lowest in Timor-Leste (2.0). For leukemia, CIR was highest in Singapore (11.1) and lowest in Myanmar (3.1) and Timor-Leste (2.6); ASIR was highest in Singapore (8.9) and lowest in Myanmar (3.2) and Timor-Leste (2.9). CMR was highest in Singapore (5.2) and lowest in Myanmar (2.6) and Timor-Leste (2.3). ASMR was highest in Lao PDR (4.7) and Vietnam (4.5), and lowest in Singapore (3.1) and Timor-Leste (2.9). For MM, CIR was highest in Singapore (4.1), ASIR was highest in Brunei (2.4) and both are lowest in Myanmar (0.4). CMR was highest in Singapore &amp; Thailand (1.8) and lowest in Myanmar (0.35); ASMR rates were similar. For HL, CIR was highest in Brunei Darussalam (1.8) and Singapore (1.4) and lowest in Myanmar (0.2). ASIR trends were similar. CMR was highest in Vietnam (0.26) and lowest in Singapore (0.1) and Myanmar (0.08). ASMR trends were similar. Conclusions: Despite lower regional average incidence and mortality, significant intra-regional variations exist reflecting disparities in the management of HCs. In addition, while data suggests lower disease burden in SEA, mortality rates are still comparable and in some cases worse than the global average. More work is needed to investigate HC epidemiology in SEA to inform cancer control in the region and improve its blood cancer outcomes. [Table: see text]