ABSTRACT Objective: Mental health is a pressing concern for South Asian Americans (SAAs) and Southeast Asian Americans (SEAAs) in the U.S. However, research on mental health support specifically for these populations is limited. Given their unique experiences as racial minorities in the U.S., this study aims to identify culturally relevant factors impacting youth mental health and examine culturally sensitive ways to adapt Youth Mental Health First Aid (YMHFA) for SAA and SEAA communities. Method: We conducted two focus group interviews with 10 SAA and SEAA mental health professionals and two focus group interviews with six SAA and SEAA parents who had received YMHFA training. These interviews were transcribed verbatim and analyzed using thematic analysis. The two coders established good interrater reliability with a kappa of .90. Results: Findings identified themes such as barriers to help-seeking, protective factors, considerations for cultural adaptation of YMHFA when working with SAA and SEAA families, and parents’ experience utilizing ALGEE. Some sub-themes include acculturative stress, stigma, cultural strengths, family values, building community partnerships, coping strategies, and psychoeducation. Discussion: This study describes prevalent barriers and facilitators to mental health and explores clinical and research implications of working with SAA and SEAA youth and families.