South America Research Articles

Climate‐Driven Projections of Future Global Wetlands Extent

AbstractWetlands are crucial components of the Earth's system, interacting with various processes such as the hydrological cycle, energy exchanges with the atmosphere, and global nitrogen and carbon cycles. The future trajectory of wetlands is anticipated to be influenced not only by direct human activities, but also by climate change. Here we present our assessment of climate‐driven global changes in wetlands extent, focusing on the main wetland complexes. We used an approach based on the Topographic Hydrological model (TOPMODEL) and soil liquid water content projections from 14 models of the Coupled Model Intercomparison Project Phase 6 (CMIP6). Our analysis reveals a consistent decrease in wetlands extent in the Mediterranean, Central America, and northern South America, with a substantial loss of 28% in the western Amazon Basin for the end of the 21st century (2081–2100) under the SSP370 scenario. Conversely, Central Africa exhibits an increase in wetlands extent, except in the Congo Basin. Nevertheless, most of the areas studied (80%) present uncertain results, due to conflicting projections of changes between the models. Notably, we show that there is significant uncertainty among CMIP6 models regarding liquid soil water content in high latitudes. By narrowing our focus to 10 models, which seem to better represent the thawing of permafrost, we obtain a better inter‐model agreement. We then find a modest declines in the overall global area (<5%), but an average loss of 13% beyond 50°N. Specific areas like the Hudson Bay Lowlands experiencing a 21% decrease and the Western Siberian Lowlands a 15% decrease.

Genetic structure and climate niche differentiation among populations of Leopardus geoffroyi.

Geoffroy's cat (Leopardus geoffroyi) is a small-sized felid native to South America. Given the species' distribution covering a wide variety of habitats, and the presence of high levels of anthropization in part of its range, it is possible that genetically differentiated groups exist and that they occupy different climatic niches. We assessed patterns of contemporary genetic diversity and structure in the species across most of its range, characterizing each inferred genetic group based on ecological niche models. We genotyped 11 microsatellites for 142 samples covering most of Geoffroy's cat distribution, and investigated patterns of genetic structure and diversity, applying spatial and nonspatial Bayesian clustering methods and a spatial principal component analysis. We created ecological niche models for each genetic cluster, evaluating whether these clusters occupy different climatic spaces and display differences in the suitability of different values of the climatic variables analyzed. We identified two genetic clusters, one in the north-northeast and the other in the south-southwest of the species' distribution. These clusters showed moderate FST values between them and differences in dispersal/genetic diversity. We found isolation-by-distance patterns globally and within each cluster. We observed lower expected heterozygosity compared with other studies and a north-south gradient in allelic richness. The southern cluster showed lower genetic variability and a more restricted climatic niche suggesting that this group is more vulnerable to the effects of the current context of climate change. Individuals from the southern genetic cluster are under different pressures, likely a product of the particularly dry habitat they occupy. Climatic variables associated with habitat suitability suggest the southern cluster has affinity for the arid and semiarid conditions present in its distribution. Conservation measures should consider the genetic structure observed and differences in climatic spaces to maintain the evolutionary potential of the species.

Bottom-up processes drive isotopic variation in the South American sea lion Otaria flavescens across a 2300 km latitudinal gradient

Spatial differences in the isotope values of widely distributed marine apex consumers may reflect geographical differences in the isotopic composition of basal resources (e.g., phytoplankton) fueling food webs (bottom-up effects) or spatial differences in the trophic ecology of the taxon of interest (top-down effects). We examined spatial variation in δ13C and δ15N values from 264 South American sea lions (SASL, Otaria flavescens) of different age classes (adults, subadults and juveniles), their putative prey consisting of pelagic and benthic coastal fishes, and particulate organic matter (POM) measured from locations situated across >2300 km of the Chilean coast (between 18°42´ and 39°17´ S). We used generalized least squares (GLS) models to compare the form of the relationship between δ13C and δ15N and latitude between the three functional groups. Our results show that SASL from northern, central, and southern areas were isotopically distinct, with individuals from the north having lower δ13C and higher δ15N values in comparison to individuals from the south. When the relationship for each functional group was modelled individually using GLS, results indicated that for each degree of increasing latitude δ15N decreased on average by 0.12‰ (POM), 0.15‰ (prey), and 0.14‰ (SASL), while δ13C increased by 0.06‰ (POM) and 0.05‰ in both prey and SASL. We suggest that the latitudinal differences observed in SASL δ13C and δ15N values reflect baseline isotopic variation rather than marked differences in trophic ecology of these widely distributed consumers.

Impacts of AMOC Collapse on Monsoon Rainfall: A Multi‐Model Comparison

AbstractA collapse of the Atlantic Meridional Overturning Circulation (AMOC) would have substantial impacts on global precipitation patterns, especially in the vulnerable tropical monsoon regions. We assess these impacts in experiments that apply the same freshwater hosing to four state‐of‐the‐art climate models with bistable AMOC. As opposed to previous results, we find that the spatial and seasonal patterns of precipitation change are remarkably consistent across models. We focus on the South American Monsoon (SAM), the West African Monsoon (WAM), the Indian Summer Monsoon (ISM) and the East Asian Summer Monsoon (EASM). Models consistently suggest substantial disruptions for WAM, ISM, and EASM with shorter wet and longer dry seasons (−29.07%, −18.76%, and −3.78% ensemble mean annual rainfall change, respectively). Models also agree on changes for the SAM, suggesting rainfall increases overall, in contrast to previous studies. These are more pronounced in the southern Amazon (+43.79%), accompanied by decreasing dry‐season length. Consistently across models, our results suggest a robust and major rearranging of all tropical monsoon systems in response to an AMOC collapse.

Maritime Disputes from a Global Perspective and Solutions under International Law

This study explores the utilization and challenges of international laws in resolving global maritime disputes through a detailed analysis of representative cases from South America, Africa, and Asia. It highlights the crucial role of international law, particularly the United Nations Convention on the Law of the Sea (UNCLOS), in providing a legal framework and dispute resolution mechanisms. However, the study also identifies significant challenges, including political interference, legal ambiguity, and enforcement issues. By comparing regional dispute settlement mechanisms, the study demonstrates the effectiveness of multilateral negotiations in South America, regional legal frameworks in Africa, and a combination of multilateral and unilateral actions in Asia. Based on these insights, the study proposes several recommendations to enhance the international legal framework, promote regional cooperation, and innovate dispute resolution mechanisms. These measures aim to ensure fair and effective resolution of maritime disputes, maintain maritime peace and stability, and promote the healthy development of global ocean governance.

The Association Between Menstrual Cycle Phase, Menstrual Irregularities, Contraceptive Use and Musculoskeletal Injury Among Female Athletes: A Scoping Review.

The influence of menstrual cycle phases (MCPs), menstrual irregularities (MI) and hormonal contraceptive (HC) use on injury among female athletes has been scrutinised. Existing systematic reviews investigating the effect of exposures affecting the endogenous reproductive hormone status on sporting injuries are limited in terms of the types of studies included and injuries investigated. This scoping review aims to summarise the coverage of the literature related to the extent, nature and characteristics of the influence of MCP, MI and HC use on musculoskeletal injuries among athletes. It also aims to summarise key concepts and definitions in the relevant literature. Observational and experimental studies investigating the effect of MCP, MI, and HC on musculoskeletal injuries among female individuals of reproductive age were included. Studies specifically stating pregnant women, perimenopausal/postmenopausal athletes, or those using medication (other than HC) that affects reproductive hormone profiles or the musculoskeletal system were excluded. This scoping review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping reviews and JBI scoping review guidelines. Published and unpublished studies were sourced from several databases and resources. Initial keywords used included terms related to "menstrual cycle", "hormonal contraception" and "injury." Titles and abstracts of identified citations were screened independently and assessed for eligibility by two independent reviewers. Data from the included studies were extracted using a standard data extraction form. The search yielded 10,696 articles, of which 96 met the eligibility criteria. Most studies investigated MI (77%), and 49% included MCP as a contributing injury risk factor. Publications have increased over the last two decades. Collectively, only 16% of research has been conducted in Africa, Asia and Oceania. There were no studies from South America. Seventy-five percent of the studies investigated individual versus team (25%) sport athletes. Most studies only investigated elite or professional (n = 24; 25%) level athletes. The definitions of injury, eumenorrhea and MI differ vastly among studies. Regarding MI, most studies (69%) investigated secondary amenorrhea, followed by oligomenorrhea (51%) and primary amenorrhea (43%). Concerning HC, the influence of oral contraceptive pills was mainly investigated. Research related to MCP, MI and HC as contributing musculoskeletal injury risk factors is increasing; however, several gaps have been identified, including research from countries other than North America and Europe, the study population being non-professional/elite level athletes, athletes participating in team sports and specific injuries related to MCP, MI and HC, respectively. Differences in methodology and terminology of injury, MCP and MI hinder comparative summative research, and future research should consider current published guidelines during the study design. Identifying barriers to following standard guidelines or research investigating the most practical yet accurate methods to investigate the influence of MCP on musculoskeletal health might yield valuable insights for future research designs. Scoping review registration number: Open Science Framework ( https://doi.org/10.17605/OSF.IO/5GWBV ).

The Impact of Transportation on The Avocado Market in Tanzania

Avocado (Persea americana) is grown in many nations throughout Africa, Asia, Europe, and South America. The climate of Tanzania offers a perfect habitat for growing avocados. This paper investigates how transportation affects the Tanzanian avocado industry. Data were gathered from 505 farmers and 37 categories/groups using a cross-sectional design. Data analysis was done using SPSS where descriptive statistics and the chi-square test. A one-way analysis of variance (ANOVA) with Tukey's Honest Significant Difference (HSD) test at p < 0.05 was also done. According to the results, local avocado output is dominated by men (79% male vs. 21% female). The result of the binary logit model revealed that the participation of avocado producers in a high-value market was influenced by age, educational status, the number of avocados sold, the price of avocado, and market information. With sorting (12%), grading (7%), and packaging (9%), quality during production was judged most important (25%), followed by harvesting (16%), storage (16%), and transportation (15%) with less relevance were factors impacting quality. Improving the avocado market for growers depends on addressing these problems at the national, regional, and district levels. Hence, transportation has a big influence on the avocado industry since smallholder growers have great difficulties influencing market access and produce quality. Improvement of transport infrastructure and support systems at the national, regional, and district levels will help to boost the avocado market.

Variability of Winter Frosts in Central South America: Quantifying Mechanisms with Decision Trees

AbstractAgricultural production in Central South America (CSA) is substantially influenced by frost events. This study characterises and quantifies the physical processes leading to frost conditions in CSA from 1979 to 2022, focusing on three innovative aspects: regional frost properties, a novel multi-parametric upper-level jet description, and the quantification of underlying mechanisms through decision trees (DTs). The regionalisation analysis identifies five homogeneous frost regions in CSA. In all regions, the events tend to occur more frequently during the La Niña phase. Moreover, a significant increase in the frequency of widespread frost events has been observed in the Argentinean Pampas during the study period, primarily due to negative trends in minimum temperatures. Furthermore, the synoptic mechanisms triggering frosts, such as cold fronts and post-frontal anticyclones enhanced by subsidence near the subtropical jet (STJ) entrance, have not shown major long-term changes. To describe the jets, we compute six parameters for the STJ and seven for the polar front jet, including latitude, intensity, height, tilting, longitudinal extent, and branch number. DTs are used to identify key jet parameters linked to frost events, such as the latitude, longitudinal extent, and tilt of the Atlantic STJ. Frost likelihood increases when the STJ is north of 31°S, and the extension of the Atlantic STJ is longer than 35° and has a negative tilt. Finally, DTs focused on the onset and end of events highlight geopotential height anomalies and STJ extension as critical variables. These DTs provide concise and accessible information for agricultural decision-makers in CSA.

Daily variation and repeatability of advertisement calls in an austral temperate forest frog under controlled conditions

AbstractEstimating repeatability allows a first approximation that may indicate a potential response to selection of sexual traits. Acoustic sexual signals comprise spectral and temporal variables, where the former generally have lower intra‐individual variation and higher repeatability values. Studies of repeatability in anurans have been conducted mainly in natural conditions, but the stability of laboratory settings allows extended recording intervals, favoring measurement accuracy. We conducted a study of variation and repeatability of the calls of males of Batrachyla taeniata, a frog from the South American temperate forest to evaluate under homogeneous environmental and social conditions: (i) the extent of variation in acoustic properties of calls within and among days, (ii) the extent of temporal variation in the repeatability of call properties, and (iii) differences in repeatability among call variables. Variation of acoustic properties differed within and across days of recording, call rate generally increased within and throughout days, suggesting sensitization processes. Call duration decreased during these time spans, yielding constant calling effort. In contrast, the dominant frequency decreased within days but increased across days. Overall repeatability differs significantly among variables: dominant frequency, call rate, and call duration having the highest, intermediate, and lowest values, respectively. The high repeatability of call rate relative to call duration contrasts with an opposing general tendency in previous studies in anurans. The repeatability of the three variables analyzed increases within days, and the repeatability of call rate also increases throughout days, highlighting the relevance of this variable for individual identity over different time ranges.

Institutional dynamics in higher education in South America: An exploration of university mergers and acquisitions

Institutional dynamics in higher education in South America: An exploration of university mergers and acquisitions

Rab27a GTPase and its effector Myosin Va are host factors required for efficient Oropouche virus cell egress.

Oropouche fever, a debilitating illness common in South America, is caused by Oropouche virus (OROV), an arbovirus. OROV belongs to the Peribunyaviridae family, a large group of RNA viruses. Little is known about the biology of Peribunyaviridae in host cells, especially assembly and egress processes. Our research reveals that the small GTPase Rab27a mediates intracellular transport of OROV induced compartments and viral release from infected cells. We show that Rab27a interacts with OROV glycoproteins and colocalizes with OROV during late phases of the infection cycle. Moreover, Rab27a activity is required for OROV trafficking to the cell periphery and efficient release of infectious particles. Consistently, depleting Rab27a's downstream effector, Myosin Va, or inhibiting actin polymerization also hinders OROV compartments targeting to the cell periphery and infectious viral particle egress. These data indicate that OROV hijacks Rab27a activity for intracellular transport and cell externalization. Understanding these crucial mechanisms of OROV's replication cycle may offer potential targets for therapeutic interventions and aid in controlling the spread of Oropouche fever.

Mortality in Patients with 22q11.2 Rearrangements

The 22q11.2 region is highly susceptible to genomic rearrangements leading to multiple genomic disorders, including 22q11.2 microdeletion syndrome (22q11.2 DS) (MIM# 188400), 22q11.2 microduplication syndrome (MIM# 608363), supernumerary der(22)t(11;22) syndrome (also known as Emanuel Syndrome; MIM# 609029), and Cat Eye Syndrome (MIM# 115470). In this study, we present data on causes of mortality, average age of death, and the existing associated risk factors in patients with 22q11.2 rearrangements. Our cohort included 223 patients (120 males and 103 females) with confirmed diagnoses of 22q11.2 rearrangements diagnosed through molecular techniques (FISH, MLPA, and CMA). Relatives from patients who have been molecularly confirmed with 22q11.2 rearrangements have also been added to the study, regardless of the presence or absence of symptoms. Of these 223 individuals, 21 (9.4%) died. Deceased patients’ rearrangements include 19 microdeletions, 1 microduplication, and 1 patient with a marker chromosome. The median age of death was 3 months and 18 days (ranging from 3 days to 34 years). There were 17 patients who died at pediatric age (80.95%), 3 died at adult age (14.28%), and for 1 of whom, the age of death is unknown (4.76%). Eighteen patients were White Mediterranean (European non-Finnish) (85.71%) whereas three were Amerindian (South American) (14.28%). Mortality from cardiac causes accounted for 71.42%. The second most frequent cause of death was sepsis in two patients (9.52%). One patient died from respiratory failure (4.76%) and one from renal failure (4.76%). Information regarding the cause of death was not available in two patients (9.52%). Most patients who died were diagnosed within the first week of life, the majority on the first day. This study adds additional information on mortality in one of the largest cohorts of patients with 22q11.2 rearrangements in more than 30 years of follow-up.

Pesticides in Latin American and Caribbean freshwater: a critical review

Pesticides used in food production contaminate freshwater ecosystems. We present a critical analysis of pesticide use in Latin America and the Caribbean (LAC) from 1990 to 2020 and a systematic review of scientific literature about the presence of pesticides in freshwater, encompassing studies published from 1990 to 2023. Data were collected from FAOStat, PubMed, ScienceDirect, Scopus, and Google Scholar. Brazil was the primary pesticide user, with an annual consumption of 231,621 t, followed by Argentina (132,255 t) and Colombia (52,553 t). In 2020, LAC had the highest rate of pesticide application globally, with Ecuador leading at 13.74 kg/ha. South America dominates the total amount with 90.9% of pesticide use, primarily herbicides (51.5%), while pesticide usage in North and Central America, as well as the Caribbean, varied due to differing agricultural practices. The study examined 221 records for 26 out of 51 countries in the literature, highlighting the significant lack of information from numerous countries. Argentina, Mexico, and Brazil had the highest publication rates. Rivers, streams, and lakes (37%, 20%, and 12%, respectively) were the most commonly studied systems, and research focused mainly on pesticide concentration in water (46%), sediments (27%), and aquatic biota (15%). The imbalance between pesticide usage and monitoring in freshwaters leads to concerns about the awareness of ecological risk. Therefore, there is an urgent need for increased research on environmental monitoring in LAC to better understand pesticide impacts on these vital ecosystems.

The Black Consciousness Movement in Azania (South Africa): A triple heritage

Starting with the 2015 Rhodes Must Fall campaign, there has been renewed interest in the philosophy of black consciousness through popular expressions – on social media and mainstream media articles – and by scholars. This article seeks to revisit the origins of the Black Consciousness Movement (BCM) in Azania (South Africa). Through an examination of primary sources, that is, documents written by the activist writers of the movement and secondary sources by scholars who reflect on the movement and other expressions of black resistance against colonialism and the oppression of black people globally, this article relies mainly on literature review of documents that are in the public domain. The overall findings of the review show that the BCM drew inspiration from and was shaped by the ‘black radical tradition’ influences from North America (specifically the United States), the Caribbean and South American region, and from the African continent, including locally in South Africa. While shaped by these influences the BCM adapted them and responded to the peculiarities of the condition of black people in South Africa and thus formulated a unique brand of black consciousness. The conclusion reached herein is that movements and the ideas that they espouse, are often confluences of views and practices drawn from different sources.Transdisciplinary Contribution: This article contributes to the understanding of the evolution of political movements from a variety of disciplines – political studies, history, sociology of ideas, history of consciousness and political philosophy.

New chondrichthyan remains from the Devonian of Brazil and their implication for Devonian vertebrate distribution

ABSTRACT The mysterious scarcity of ‘fish’ in an extensive epicontinental sea has always intrigued countless researchers who worked with the South American Devonian, especially in the Malvinoxhosan (= Malvinokaffric) Paraná Basin. This scarcity is probably related to taphonomic factors and/or lack of experience of collectors with fossil ‘fish’. Currently, the vertebrate record of the Devonian of the Paraná Basin is restricted to three chondrichthyan fin fragments and an actinopterygian mandible. Here we describe the first ‘fish’ fossils from the northwest edge of the Paraná Basin, represented by Chondrichthyan fin spine, scales, and teeth, consisting in the oldest Devonian ‘fish’ in the basin, attributed to the Pragian-Emsian of Mato Grosso do Sul state. The morphology of the fin-spine is consistent with a stem chondrichthyan morphotype, and the teeth bear resemblance in cusp morphology to those of the protacrodontid type. Despite the low taxonomic refinement, this new record in the Devonian of the Paraná Basin shows the presence of ‘fish’ throughout the Basin already in the late Pragian – early Emsian. This is relevant, because the Paraná Basin is an important region for better understanding the distribution of the South American Devonian vertebrate fauna through time and space.

Moho depth model of South America from a machine learning approach

Crustal structure models play an important role in the characterization of seismogenic zones, in the regional delimitation of geological provinces and particularly, in understanding the genesis and evolution of sedimentary basins. Despite the increasing number of new seismic surveys and seismographic networks in South America, crustal thickness measurements are still scarce and irregularly sampled, reducing the resolution of crustal model maps. To overcome these challenges, a novel approach based on machine learning techniques is proposed, in order to explore higher resolution gravity datasets in the interpolation of crustal thickness measurement points obtained from previous seismic/seismological compilations. The algorithm used in this study is based on Gaussian processes prediction methods, which allowed inferring the depth of Moho to South America. The prediction error of the model obtained from the training and testing database was 3.48 km, which is compatible with the uncertainties derived from the H-k stacking analysis. The depth range varied from 69.8 km beneath the Andes to 4.3 km in oceanic regions. The average Moho depth for the South American Platform is 39.1 km, allowing a spatial correlation of deeper and shallower Moho regions with different types of continental basins. Compared to other models, the model resulting from this study presents fine-scale features highlighting the limits of the main tectonic domains and a good agreement with the suture zones. Overall, this study demonstrates the potential of applying machine learning tools in crustal-scale imaging using sparse datasets, providing new advances in Moho modeling of the South America, as well as new perspectives on its the history and tectonic evolution.

Fatal journeys: causes of death in international travellers in South America.

Understanding mortality among travellers is essential for mitigating risks and enhancing travel safety. However, limited evidence exists on severe illnesses and injuries leading to death among travellers, particularly in low- and middle-income countries and remote regions. We conducted a retrospective census study using country-level observational data from death certificates of travellers of seven South American countries (Argentina, Brazil, Chile, Colombia, Ecuador, Peru, and Uruguay) from 2017 to 2021. Causes of death were evaluated using ICD-10 codes, categorised into non-communicable diseases (NCDs), communicable diseases, and injuries. We quantified causes of death by demographic characteristics (e.g. age, sex), and geographical variables. Chi-square tests were used to assess differences between categories. We calculated crude mortality rates and incidence rate ratios (IRRs) per country's subregions. A total of 17 245 deaths were reported. NCDs (55%) were the most common cause of death, followed by communicable diseases (23.4%) and injuries (18.1%). NCD-associated deaths increased after age 55years and were highest among ≥85years. Communicable diseases were more common at younger age (<20years). Injury-associated deaths were more common in men (79.9%) and 25-29-year-olds (17.1%). Most deaths (68.2%) could have been avoided by prevention or treatment. Mortality risk was higher among travellers in bordering regions between countries. In Roraima [Brazil] and Norte de Santander [Colombia], locations bordering Venezuela, the death incidence rate ratio was 863 and 60, respectively. These countries' reference mortality rates in those regions were much lower. More than 80% of the deaths in these border regions of Brazil and Colombia involved Venezuelan citizens. Conclusion: The study identified risk factors and high-risk locations for deaths among travellers in seven countries of South America. Our findings underscore the need for specific health interventions tailored to traveller demographics and destination to optimise prevention of avoidable deaths in South America.

DIGITAL QUALITY OF SOCIETY’S LIFE AS A RESULT OF ECONOMIC GROWTH IN THE CONDITIONS OF INSTITUTIONAL AND STRUCTURAL CHANGES

At the current stage of its development, the world is in conditions of global digitalization, the events of recent years only accelerate technological processes. Advanced digital technologies are changing both the approach to the implementation of human life processes and the vector of socio-economic development of the country. The digital transformation of the economy affects all economic relations with the active use of modern ICT, and the well-being of the population is measured by the digital quality of life. The author analyzed the dynamics of changes in the ranking of individual countries of the world according to the Digital Quality of Life (DQL) Index in 2022–2023 and found that France and Finland became the leaders in 2023, while Ukraine took only 46th place. It has been established that the higher the GDP per capita, the higher the DQL Index, this is particularly evident in Western Europe, South America, Australia and New Zealand, and Northern Europe. It found that a country’s digital quality of life is affected by its access to the Internet and in 2023, the global trend shows increased Internet access, and people needed to work 11% less to afford fixed broadband Internet access. The article also examines the dynamics of changes in the rating of individual countries of the world for the development of e-security and e-infrastructure according to the DQL Index in 2022–2023, as a result of which it was found that Ukraine has positive dynamics towards the improvement of e-security. In order to improve the level of digital quality of life in Ukraine, it is proposed to create conditions for learning how to work with digital technologies and platforms; to form digital literacy of the country’s population; strengthen information security; support businesses in using modern digital business models.

Re-design methodology for an under-risk multi-business supply network

ABSTRACT Currently, several supply chains of the same business may be managed independently. This is due to different groups of clients or different marketing channels. Parallely, changes in the environment, due to unexpected situations, lead the decision-makers to modify the configuration of supply chains. Therefore, we propose a redesign methodology based on a progression of steps to study holistic synergies. This design analysis is carried out at a static and dynamic level for strategic, tactical and operational decisions. The use of qualitative and quantitative tools allows a set of solutions to be obtained, which take into account inventory levels, processing times, costs and service levels. To compare the preliminary solutions, AHP (Analytic Hierarchical Process) is combined with TOPSIS (Technique for Order of Preference by Similarity to Ideal Solution). It is applied to an example of pharmaceutical distribution in South America. The results indicate an improvement of service levels and a reduction of costs from risks.

Histoplasma capsulatum urinary antigen detection in a kidney transplant recipient with acute paracoccidioidomycosis: Case study and literature review.

Paracoccidioidomycosis (PCM) and histoplasmosis are endemic fungal diseases in South America. Both can lead to lung involvement with fungal dissemination progressing to systemic and severe clinical manifestations, especially in immunosuppressed hosts. As the population of immunosuppressed individuals has been rising, a higher occurrence of fungal infections is predicted in this setting. This poses challenges regarding the differential diagnosis due to overlapping clinical and laboratorial findings, hampering the management of cases. In this study, the authors discuss the occurrence of a false-positive Histoplasma urinary antigen detection in a kidney transplant recipient with acute PCM. Given the scarce information about this subject, a review on literature data is provided. A comprehensive literature search was conducted to investigate previous studies that found cross-reactivity between Histoplasma urinary antigen assays in human patients with confirmed diagnosis of PCM. Additionally, an update of PCM in transplant recipients is provided. The included studies reported 120 samples from patients with PCM tested for Histoplasma antigen, presenting an overall cross-reactivity of 51.67% and 17 cases of PCM in transplant recipients. CONCLUSIONS: The galactomannan urinary antigen developed to diagnose histoplasmosis can cross react with PCM, which may represent a concern in countries where both mycoses overlap.