Current watershed-scale, nonpoint source pollution models do not represent the processes and impacts of agricultural best management practices on water quality with sufficient detail. A Water Erosion Prediction Project-Water Quality (WEPP-WQ) model was recently developed which is capable of simulating nonpoint source pollutant transport in nonuniform hillslope conditions such as those with BMPs. However, WEPP-WQ has not been validated for these conditions, and prior validation work only evaluated calibrated performance rather than uncalibrated performance, with the latter being most relevant to model applications. This study evaluated uncalibrated and calibrated model performance in two plot-scale, artificial rainfall studies. 179 observations were compared to corresponding WEPP-WQ simulations of runoff, sediment yield, and soluble and particulate nutrient forms for both nitrogen and phosphorus. Uncalibrated validation results were mixed for the different field conditions, model configurations, and prediction variables. Nash-Sutcliffe Efficiencies for uncalibrated simulations of uniform conditions were generally greater than 0.6 except for soluble nitrogen predictions which were poor. Simulations of nonuniform conditions were generally ‘unsatisfactory’ except for runoff predictions which were quite good (NSE = 0.78). Performance was improved substantially for almost all endpoints with calibration. Some exceptions to this occurred because the objective function for calibration was based on log-space differences so as to more equally-weight calibration of unsaturated conditions that tend to produce lesser runoff volumes and sediment yields. Calibrated results for both uniform and nonuniform conditions were generally ‘satisfactory’ or ‘good’ according to widely accepted model performance criteria.