BACKGROUND AND AIM: Wood burning is a primary energy source for heating but constitutes a significant source of PM2.5 emissions and is linked to adverse health outcomes, including preterm birth (PTB). There is little evidence on the expected benefits from air pollution mitigation plans with respect to perinatal outcomes, particularly those aimed at decreasing residential wood-burning emissions. We estimated the magnitude of reduction in prevalence and number of PTB cases associated with compliance with air quality guidelines and specific interventions to reduce fine particulate matter in Temuco/Padre Las Casas, Chile, an area heavily affected by wood burning from residential heating. METHODS: A parametric G-computation approach was applied to quantify the relationship between PM2.5 and time to PTB. We relied on a retrospective cohort of all live births between 2009-2015 from a public hospital in Temuco (n=15,516). We simulated the effects of four scenarios to reduce PM2.5 as compared to “business as usual” (no intervention): compliance with i) WHO guidelines; ii) Chilean limit values; reductions associated with iii) a wood heater replacement program and iv) gradual prohibition of less efficient stoves/heaters. RESULTS:Women were exposed to high levels of air pollution in each trimester of pregnancy (30 µg/m3 in each trimester); 10% of births were PTB. Both prevalence and number of cases of PTB decreased with each intervention scenario, with larger decreases associated with compliance to national limits and international guidelines. For gradual prohibition of less efficient stoves, expected prevalence of PTB was 8% compared to 5.7% associated with compliance with Chilean limits, which represented 225 (95% CI -395, -56) and 544 (95% CI -897, -190) fewer cases of PTB compared to business as usual. CONCLUSIONS:We found large potential benefits for prevalence and number of PTB cases associated with the mitigation strategies, with larger reductions for norm compliance compared to specific wood-burning proposed. KEYWORDS: air pollution, mitigation strategies, adverse birth outcomes, G methods