The flow-induced noise has become an important noise source in marine sonar self-noise, which can adversely affect the normal operation of sonar. The marine sonar cabin is simplified as a cavity-plate-exterior space coupled system whose flow-induced vibro-acoustic characteristics are investigated in this paper. An isogeometric vibro-acoustic formulation is proposed in which the cavity with an irregular geometry is precisely described by adjusting the control points and corresponding weights. The flow-induced vibro-acoustic response is obtained by transferring the turbulent pressure data from computational fluid dynamics into the isogeometric vibro-acoustic model. Imposing turbulent pressure into the isogeometric control points is proposed to achieve this objective using a node-based interpolation method. The vibro-acoustic modeling is validated and compared with previous experimental results. These comparisons demonstrate that the developed formulation accurately predicts the vibro-acoustic characteristics of the fluid-excited coupled system. The influences of flow speed, acoustic medium, and cavity shape on flow-excited vibration and sound radiation are discussed. Results show a decrease in radiated acoustic power and radiation efficiency in the exterior space, and a shift in the plate-exterior space coupling modal frequency to lower frequencies when the cavity changes from convex to concave.