IT HAS BEEN demonstrated that the hormones of the anterior lobe of the hypophysis and the ovaries exert a mutual effect upon each other (i). In the involutional period the activity of the anterior lobe of the pituitary has been found to be definitely increased (2). When estrogenic hormone is given to these women in the involutional period there is found to be a defi' nite decrease in the excretion of gonadotropic hormone which seems to point to the inhibiting effect of the ovarian hormone upon the anterior lobe of the pituitary. KirkHa and Wilder (3) demonstrated that the somatotropic function of the pituitary was depressed by follicular hormone in certain acromegaloid individuals at menopause, which indicates that the action of follicular hormone on the pituitary is not limited to the depression of a single function. Although we have some insight into the action.
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