Somatic Components Research Articles

Primary mediastinal germ cell tumors - A retrospective analysis of >30 years of experience in a single institution.

BackgroundThis study was performed to clarify the treatment outcome of patients with primary mediastinal germ cell tumors (PMGCTs), focusing on the clinical manifestations and management during definitive therapy and long‐term follow‐up.MethodsIn this study, we retrospectively reviewed the medical records of patients with PMGCTs treated at Shinshu University School of Medicine, and examined the clinical profiles and treatment outcomes of 22 patients (mean age of 29 years) with primary mediastinal GCTs treated at our hospital between 1983 and 2019.ResultsFive patients were diagnosed with pure seminoma and 17 had nonseminomatous GCT. A total of 21 patients were treated with cisplatin‐based chemotherapy and 15 patients (68.2%) underwent thoracic surgery after chemotherapy. Although all cases of nonseminomatous GCT were negative for tumor markers after cisplatin‐based chemotherapy, two cases showed variable GCT cells and two had somatic components (angiosarcoma and rhabdomyosarcoma) in resected specimens. Three relapsed soon after surgery. Growing teratoma syndrome developed during chemotherapy in four cases. Urgent thoracic surgery was performed in three patients, but one case was inoperable. The calculated 10‐year overall survival rates were 100% in mediastinal seminoma and 64.7% in NSGCT. During follow‐up, second non‐GCT malignancies developed in three patients (colon cancer, 190 months; thyroid cancer, 260 months; non‐small cell lung cancer, 250 months after the initial chemotherapy) and one patient with primary mediastinal seminoma was associated with multiple type I endocrine tumors.ConclusionsOur experiences demonstrated that long‐term survival and/or cure can be achieved with adequate chemotherapy followed by local surgical treatment even in patients with mediastinal GCTs. However, the clinical manifestations and biological behaviors during and/or after chemotherapy were complex and varied. In addition, the development of secondary malignancies should be taken into consideration for long‐term follow‐up. Clinicians should be aware of the various clinical features and secondary malignancies in primary mediastinal GCTs.

Metaphoric basis of the compound nouns with a somatic component in the German mass media (exemplified by the publications about Donald Trump)

Metaphoric basis of the compound nouns with a somatic component in the German mass media (exemplified by the publications about Donald Trump)

Comparison of Analgesic Efficacy of Erector Spinae and Oblique Subcostal Transverse Abdominis Plane Block in Laparoscopic Cholecystectomy

Introduction: The pain after Laparoscopic Cholecystectomy (LC) which has both somatic and visceral component. Interfascial plane blocks play a major role in Multimodal Analgesia (MMA). Previous studies have found good analgesic benefits with Erector Spinae Plane (ESP) and Oblique Subcostal Transversus Abdominis Plane (OSTAP) blocks. However, till date no study exists which compares the above blocks with addition of dexamethasone. Aim: To compare ESP with OSTAP block using low concentration of Local Anaesthetic (LA) and dexamethasone as part of MMA in elective LC. Materials and Methods: A total of 66 patients were included in this study and finally, 60 patients were analysed. They were randomised to receive either bilateral ESP at T7 level or bilateral OSTAP with 20 mL 0.2% ropivacaine and 4 mg dexamethasone before starting anaesthesia. Primary outcome measures were total opioid consumption and mean Visual Analog Scale (VAS) in the first 24 hours postoperatively. Secondary outcome measures were intraoperative opioid consumption, opioids or block related complication, and patients’ feedback for procedural satisfaction and postoperative pain control. The results were analysed using the Statistical Package for the Social Sciences (SPSS) software version 23.0. Continuous and categorical data were analysed using appropriate statistical analysis. A p-value <0.05 was considered statistically significant. Results: Both the blocks provided excellent pain relief. The mean (24 hours) opioid consumption in ESP group was 29.83±54.74 mg and in OSTAP group was 73.17±94.04 mg; p=0.034. The mean VAS was significantly lower in the ESP block at all point of time during first 24 hours in ESP group was 0.58 and in OSTAP group was 1.72 (p<0.001). The mean intraoperative opioid requirement in ESP and OSTAP group were 6.9±1.8 mg and 7.6±2.3 mg of nalbuphine, respectively. No complications were noted in any patients. Conclusion: Addition of dexamethasone in ESP block provides significant analgesia and less opioid consumption in patients undergoing LC. Hence, ESP block can be considered as part of MMA in LC surgery.

Assessment of mental health in indian medical students during the coronavirus disease-2019 pandemic

Context: Medical students are more anxious and depressed than their peers, and the prevalence of various mental health problems is on the rise. The coronavirus disease-2019 (COVID-19) pandemic has had far-reaching psychosocial consequences on the Indian population. Aim: The aim of this study is to assess the mental health status of Indian medical students during the COVID-19 pandemic and lockdown. Settings and Design: A questionnaire-based, cross-sectional study of medical students from across India. Methodology: The general health questionnaire with 28 items (GHQ-28) was adapted to GoogleForms® and circulated extensively to medical students in various colleges across India among the nationwide lockdown that began from March 22, 2020. A total of 1000 responses were collected for a period of 1 month from May 12 to June 11. Other questions included uncertainty due to the pandemic about one's career as a medical student, satisfaction with the field of medicine, the year of training, and how long the student believed the effects of the pandemic would last. Statistical Analysis Used: A Chi-square test was applied to compare the proportions, and Mann-Whitney U or Kruskal–Wallis test was used to compare the continuous variables between the groups. Results: A total of 60.3% (57.2–63.2) of students had GHQ-28 scores above the cutoff of >23 and had mental health problems. Female sex, smoking, alcohol, dissatisfaction with medicine, and uncertainty due to the pandemic were associated with mental distress. GHQ-28 scores increased uniformly with the year of training of the student, except in the case of IInd year, where scores were the least. Similar trends existed for the somatic, anxiety, social-dysfunction, and depression score components of the GHQ-28. Conclusions: Mental health issues are very common among medical students, particularly now during the COVID-19 pandemic. Early identification along with guidance and counselling is essential for all-round development of medical professionals.

ИССЛЕДОВАНИЕ ЭФФЕКТИВНОСТИ СОЧЕТАННОГО ПРИМЕНЕНИЯ ЭЛЕКТРОТРАНКВИЛИЗАЦИИ ЦЕНТРАЛЬНОЙ НЕРВНОЙ СИСТЕМЫ И ПЕПТИДНОГО БИОРЕГУЛЯТОРА КОРТЕКСИН В ПОВЫШЕНИИ СТАТОКИНЕТИЧЕСКОЙ УСТОЙЧИВОСТИ ЧЕЛОВЕКА

The paper deals with effectiveness of 2-wk electrical tranquilization of the central nervous system (CNS ET) combined with peptide bioregulator cortexin in improvement of the statokinetic stability. Statokinetic loads were modeled using the standard test of continuous Coriolis accelerations accumulation (CCAT). Cortexin was applied intranasally twice a day at the dose of 5 mg. It was shown that CNS ET together with cortex extends the CCAT tolerance and alleviates sensory, autonomic and somatic components of statokinetic reactions. Tolerance time was the longest immediately after the course; over 3 months tolerance returned gradually to initial length.

Selected Parameters of Anaerobic Fitness and Somatic Components Among Super-league Team Handballers Playing Various Positions

Study aim: The aim of the study was to evaluate the relative mechanical work (J/kg), maximal power (W/kg) and the time to attain (s) and of maintaining (s) power in the Wingate test among super-league handballers playing different positions. Additionally, the somatic components of the body were assessed, based on measuring body composition. Material and methods: Participants: 20 players of the super-league handball team. Mean age of the subjects - 25.84 ± 3.36 years, mean body height - 191.89 ± 12.82 cm, mean body mass - 97.99 ± 7.18 kg, mean BMI - 25.85 ± 1.91. Anaerobic fitness was assessed in accordance via the Wingate-30 s test procedure, on a Monark 824E cycle ergometer, using the MCEv5.0 software program, while body composition was assessed with the Tanita SC 330, Japan body composition analyser. Results: The mean value of the maximum power among the participants was - 11.45 ± 0.86 W/kg., mean value of the work - 256.78 ± 15.93 J/kg., the mean value of the time to attain power - 4.63 ± 0.80 s., mean value of time maintaining power - 2.91 ± 1.05 s., power decrease index - 26.17 ± 3.52%. The mean value of the FAT% index - 12.92 ± 3.27% and the mean percentage of water in the body composition - TBW% - 60.94 ± 1.99. Conclusions: The selected parameters of anaerobic fitness obtained by the participants in the Wingate test were at a good and average level, which certainly did not guarantee the achievement of high sports results in the men's handball super-league competition. Higher values of the parameters regarding anaerobic fitness were obtained by the players playing in the positions: centre and winger, relative to pivots and goalkeepers. The values of body composition tissue components were within the limits of the results for referencing.

Метафоричне та метонімічне підґрунтя формування іменникових композитів із соматичним компонентом у німецьких мас-медіа

Метафоричне та метонімічне підґрунтя формування іменникових композитів із соматичним компонентом у німецьких мас-медіа

Relationship between sluggish cognitive tempo and sleep, psychological, somatic, and cognitive problems and impairment in children with autism and children with ADHD.

Sluggish cognitive tempo (SCT) is a topic of renewed interest. Much remains to be learned about its association with symptoms and diagnoses that have received little research attention, particularly sleep disturbance, somatic complaints, and autism. Our study is the first to explore the relationship between SCT and sleep, internalizing, externalizing, somatic, and cognitive problems, impairment, and demographics in large samples of children with autism, ADHD-Combined, and ADHD-Inattentive. Mothers rated 1,436 children with autism and 1,056 with ADHD without autism, 2 to 17 years, on the Pediatric Behavior Scale (PBS). Factor analysis yielded a 6-item SCT factor (sluggish/slow moving/low energy, stares/preoccupied/in own world, tires easily, in a fog/confused, drowsy/sleepy/not alert, and apathetic) plus 10 additional factors. SCT was distinct from but related to several factors and was associated with social and academic impairment. The strongest independent predictors of SCT were depression, sleeping more than normal, cognitive problems, autism, and somatic complaints. Scores on the remaining factors (sleep disturbance, attention deficit, impulsivity, hyperactivity, oppositional defiant disorder, conduct disorder, and anxiety) increased explained variance by less than 2%. Findings suggest that SCT is not simply sluggish cognitive tempo, as the name implies, and is a complex construct with behavioral, affective, emotional, cognitive, and somatic components and associations. Given that 49% of children with autism had SCT, SCT symptoms should be considered in all children being evaluated for autism, as well as for ADHD-C and ADHD-I (with SCT percentages of 31% and 40%). Assessing and treating SCT is especially important because of its association with impairment.

A sad heart: Depression and favorable cardiovascular health in Brazil

Depression is associated with poor cardiovascular health (CVH) and increased risk of cardiovascular disease in high-income countries. However, it is unclear whether depression, particularly somatic depressive symptoms, may similarly contribute to poor CVH in a different socioeconomic context. Our aim was to investigate the association between depression and CVH in Brazil, a middle-income country. 49,658 participants (≥18 years) from the 2013 National Health Survey-Brazil. Favorable CVH was defined by meeting recommended levels on five CVH components (blood pressure, body mass index, diabetes or hypercholesterolemia status, smoking status). Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9; depressed if score ≥ 10). Two PHQ-9 sub-domain scores (somatic or cognitive symptoms) were also considered. Covariates included age, sex, race, income, education, region of residence, marital status, chronic diseases, diet and physical activity. Depression was associated with a 27% lower odds of having favorable CVH (OR 0.73; 95%CI 0.62–0.86), and the association was stronger among women (OR 0.72; 95%CI 0.60–0.86). Both somatic and cognitive depression symptoms were inversely associated with lower odds of having favorable CVH. In conclusion, depression is associated with lower odds of having favorable CVH in Brazil, and associations are evident across both somatic and cognitive components of depression. Moreover, the relationship was independent of socioeconomic factors, chronic diseases, and was not strongly explained by diet or physical activity. Overall, our findings suggest that the greater odds of having poor CVH among depressed individuals is not unique to high-income countries.

Употребление и лексико-грамматические изменения идиом с соматическими компонентами glava ‘голова’, vrat ‘шея’ в сербском и хорватском языках: корпусное исследование

Употребление и лексико-грамматические изменения идиом с соматическими компонентами glava ‘голова’, vrat ‘шея’ в сербском и хорватском языках: корпусное исследование

Audiological Evaluation of Patients With Somatosensory Tinnitus Attributed to Temporomandibular Disorders.

Purpose Tinnitus and temporomandibular disorders have already been associated in the literature, but despite many studies, it is still an intriguing discussion point. This study aimed to evaluate the prevalence of hearing loss among somatosensory tinnitus patients with temporomandibular disorders and to assess the influence of tinnitus on patients' quality of life. Method An otolaryngologist examined 585 patients in order to detect and evaluate the presence of tinnitus. Subjects were evaluated using the Portuguese version of the Research Diagnostic Criteria for Temporomandibular Disorders. An analysis of the somatic component of tinnitus was performed. Tinnitus was rated according to its onset (at least 6 months) and intensity with a visual analog scale. The sample was composed of 100 patients with somatosensory tinnitus divided into two groups: Group 1 (with temporomandibular disorder, n = 85) and Group 2 (without temporomandibular disorder, n = 15). The audiological evaluation was composed of pure-tone audiometry, high-frequency audiometry, tympanometry, and transient-evoked otoacoustic emissions. The impact of tinnitus on quality of life was assessed by the Tinnitus Handicap Inventory adapted and validated to Portuguese language. Results Pure-tone audiometry did not differ with statistical significance between groups (p = .29), neither did the high-frequency audiometry results (p = .74). Tinnitus Handicap Inventory scores also did not show any differences between Groups 1 and 2 (p = .67). Conclusions Subjects with somatosensory tinnitus, who also have temporomandibular disorders, do not seem to have hearing impairment. Also, they do not have a higher quality of life handicap when compared to those without tinnitus and temporomandibular disorder.

Knockout of purinergic receptor Y13 (P2Y13) results in an improved outcome of metabolic syndrome in mice

Abstract Metabolic syndrome (MetS) clusters the main risk factors for cardiovascular diseases (CVDs) and endocrine dysfunction. The pathomechanism of MetS is described as local death of hypertrophic adipocytes releasing danger-associated molecular patterns (DAMPs) such as nucleotides (e.g. ADP). This promotes a long term inflammation of adipose tissue via activation of purinergic receptors with a gradual shift towards a pro-inflammatory environment. The ADP receptor P2Y13 is both described in metabolic and immunological processes. These combined characteristics make the P2Y13 an interesting candidate to investigate its role in MetS. Nevertheless, the role of P2Y13R in the pathogenesis of MetS is currently unknown and shall be analyzed in this study. BMDM isolation and differentiation to Mϕ using M-CSF and subsequent stimulation with medium, LPS and IFNγ or IL4; Expression was quantified using Taqman. Male C57Bl6/J wild-type (WT) and P2Y13-deficient (KO) mice were fed a HFD for 20 weeks; body weight and food consumption were recorded weekly. GTT, ITT and metabolic cages were performed after 15 weeks with euthanization after 20 weeks. In order to distinguish the effect of hematopoetic or somatic cells, mice were lethally irradiated with 9.4Gy and reconstituted with donor bone-marrow (BM) via tail vein injection. We observed a unique expression of P2Y13R on pro-inflammatory M1 Mϕ. After HFD feeding KO mice showed higher O2 consumption compared to WT mice (AUC of O2 consumption on 2nd day= KO:61620±2261mL/kg vs WT: 53830±916mL/kg, p<0.05). Although KO mice consumed more food compared to WT littermates (KO:5.7±0.5g/d vs WT:3.1±0.1g/d, p<0.0001), they showed significantly decelerated weight gain (e.g.week 15→KO:147,292±5,26% vs WT:180.8±15.9%, p<0.05). Obese KO animals outperformed obese WT littermates in a peritoneal glucose tolerance test (GTT) (2h post-injection (post-i.) →KO:273.7±46.3mg/dL vs WT: 555.0±40.8mg/dL, p<0.05). KO mice on HFD were protected from developing a fatty liver. HFD KO mice receiving WT BM show accelerated weight gain compared to KO mice receiving KO BM (e.g.week 10 WT in KO: 111.2±2.2% vs KO in KO: 102.2±1.2%, p<0.05). In the GTT irradiated KO mice either receiving KO or WT BM are protected from HFD induced impaired glucose homeostasis (45min post-i.; KO→KO:222.1±21.2mg/dL vs WT→KO:232.8±15.9mg/dL vs WT on chow diet:240.4±18.6mg/dL). Contrary, WT mice receiving KO or WT BM developed a glucose resistance comparable to non-irradiated WT mice (45min post-i.; WT→WT:423.8±61.7mg/dL vs KO→WT:434.3±51.1 vs WT on HFD:574.4±7.9). P2Y13 KO improves the outcome of MetS in mice with improved glucose homeostasis, decelerated weight gain, no fatty liver development and better metabolic turnover. BM transplantation experiments suggest a somatic component as possible explanation of these observations. Given these beneficial metabolic effects, we hypothesize that antagonization of P2Y13R could be a promising therapeutic tool in the field of MetS. Funding Acknowledgement Type of funding source: None

Analysis of the relationship between skin and emotional disorders in patients with psoriasis

107 patients (34 female and 73 male) diagnosed with “generalized psoriasis vulgaris, exudative form, progressive stage” were evaluated for the levels of anxiety and depression. These measurements were carried out along with psychiatrist interview, taking into consideration anamnestic and status information. 67,3% of patients unhesitatingly marked that a previous psychological trauma had caused the current exacerbation of psoriasis. The study reveals interrelationship between the psychiatric and somatic components of psoriasis. We managed to reach marked remission in 19 patients using low doses of psychotropic drugs along with primary dermatological treatment.

Paternal exposure to morphine during adolescence potentiates morphine withdrawal in male offspring: Involvement of the lateral paragigantocellularis nucleus.

Opiate exposure during adolescence perturbs the brain's maturation process and potentially confers long-term adverse consequences, not only in exposed individuals but also in their posterity. Here, we investigate the outcomes of adolescent paternal morphine exposure on morphine withdrawal profile in male offspring. Male Wistar rats were chronically subjected to 10 days of an escalating regimen of morphine during adolescence. After a 20-day washout period, adult males were allowed to copulate with naïve females. The adult male offspring were tested for somatic and affective components of naloxone-precipitated morphine withdrawal using conditioned place aversion. Moreover, electrical activity of the lateral paragigantocellularis (LPGi) nucleus, which is involved in development of opiate dependence, was recorded in response to a challenge dose of morphine via extracellular single-unit recordings. Morphine-sired offspring exhibited augmented expression of naloxone-induced somatic and affective signs of opiate withdrawal compared to the control saline-sired counterparts. In vivo recording revealed that LPGi neurons displayed heterogeneous responses (inhibitory, excitatory, and no change) to acute morphine administration in both morphine- and saline-sired animals. The morphine-induced discharge inhibition was potentiated in morphine-sired offspring. However, the extent of discharge excitation in response to morphine did not reach significance in these subjects. Moreover, the lack of alteration in maternal behavior toward morphine-sired offspring indicates that this is due to germline-dependent transmission of epigenetic traits across generations. Preconception paternal exposure to morphine during adolescence potentiates opiate withdrawal signs in male offspring which is mediated, at least in part, by epigenetic alteration of LPGi-related brain circuitry.

Семантика іменникових композитів із соматичним компонентом у німецькому спортивному дискурсі

Семантика іменникових композитів із соматичним компонентом у німецькому спортивному дискурсі

La Envidia: An Illness Manifest at the Level of the Community Body

AbstractIn Curanderismo and other traditional medicine systems, illnesses are understood to have somatic and emotional components and symptoms may be elicited by disruptions in interpersonal relationships between community members. An aspect of ritual interventions involves returning interpersonal relationships to balance and restoring harmonious interactions between members of the community. Important are shared understandings of the meaning of the symptoms, the mode of transmission of the illness, and the resolution that occurs through the process of the healer’s ritual interventions. In this essay, I present a narrative description of the illness, La Envidia, which is associated with the expression of the emotion, envy. The narrative was shared with me by a person who is a migrant from an Afromestizo community of the Pacific Coast of Mexico to Atlanta, Georgia. The illness, La Envidia, is discussed and interpreted framed by perspectives including Participation Mystique and blurred psychological boundaries, traditional indigenous conceptualizations of illness, shamanism and symbolization processes, shared meaning, traditional Yoruba informed African conceptualizations of illness and healing practices, and somatic and embodied ritual experiences.

Oral Administration of S-Adenosylmethionine (SAMe) and Lactobacillus Plantarum HEAL9 Improves the Mild-To-Moderate Symptoms of Depression: A Randomized, Double-Blind, Placebo-Controlled Study.

To assess the effects of the combination of SAMe (S-adenosylmethionine) 200 mg and Lactobacillus plantarum (L. plantarum) HEAL9 1 × 10⁹ CFU for the overall symptomatology of mild-to-moderate depression. This 6-week randomized, double-blind, placebo-controlled study included subjects aged 18-60 years with mild-to-moderate depression (according to ICD-10 diagnostic criteria) recruited from September 17, 2018, to October 5, 2018. Difference between groups in change from baseline to treatment week 6 on the Zung Self-Rating Depression Scale (Z-SDS) was the primary outcome. Comparisons between groups in change from baseline to treatment week 2 of the Z-SDS and from baseline to treatment weeks 2 and 6 of other scales (related to insomnia, anxiety, irritable bowel syndrome, and health status) were also analyzed. Ninety patients were randomized to SAMe plus L. plantarum HEAL9 (n = 46) or placebo (n = 44) groups. A greater reduction for the new combination compared to placebo was seen at treatment week 6 in the Z-SDS total score (P = .0165) and the core depression subdomain (P = .0247). A significant reduction in favor of the combination was shown at treatment week 2 for the Z-SDS total score (P = .0330), the cognitive and anxiety subdomains (P = .0133 and P = .0459, respectively), and the anxiety questionnaire (P = .0345). No treatment-related adverse events occurred. Supplementation of SAMe and L. plantarum HEAL9 in adults with subthreshold or mild-to-moderate symptoms of depression resulted in fast and clinically relevant effects after 2 weeks. The combination was safe and significantly improved symptoms of depression, anxiety, and cognitive and somatic components. The effect of this novel product is independent from the severity of the symptoms unlike traditional antidepressants available on the market that have minimal benefits for subthreshold or mild-to-moderate symptoms. ClinicalTrials.gov identifier: NCT03932474.

Образ «человека телесного»: соматическая лексика с компонентом «рука» в лирике А. Ахматовой

The research objectives are as follows: to identify somatic vocabulary with the component “hand” in A. Akhmatova’s works, to reveal the basic meanings and conceptions correlating with this part of the human body, to suggest interpretation of the “hand” image as a symbol of creativity. Scientific originality of the study involves a comprehensive analysis of somatic vocabulary with the component “hand” in A. Akhmatova’s poetical heritage, which allows identifying specificity of the author’s general cultural and individual perception of this somatic component. The research findings are as follows: the researchers reveal similarity of general cultural and individual-authorial interpretations of somatic words, argue for the thesis on evolution of images and meanings in the poet’s creative work.

Transient receptor potential ankyrin 1 contributes to somatic pain hypersensitivity in experimental colitis

Pain evoked by visceral inflammation is often ‘referred’ to the somatic level. Transient receptor potential ankyrin 1 (TRPA1) has been reported to contribute to visceral pain-like behavior in dextran sulfate sodium (DSS)-evoked colitis. However, the role of TRPA1 in somatic component of hypersensitivity due to visceral inflammation is unknown. The present study investigated the role of TRPA1 in colitis-evoked mechanical hypersensitivity at the somatic level. Colitis was induced in mice by adding DSS to drinking water for one week. Control and DSS-treated mice were tested for various parameters of colitis as well as mechanical pain sensitivity in abdominal and facial regions. DSS treatment caused mechanical hypersensitivity in the abdominal and facial skin. Pharmacological blockade or genetic deletion of TRPA1 prevented the colitis-associated mechanical hypersensitivity in the abdominal and facial skin areas although the severity of colitis remained unaltered. DSS treatment increased expression of TRPA1 mRNA in cultured dorsal root ganglion (DRG) neurons, but not trigeminal ganglion neurons, and selectively enhanced currents evoked by the TRPA1 agonist, allyl isothiocyanate, in cultured DRG neurons. Our findings indicate that the TRPA1 channel contributes to colitis-associated mechanical hypersensitivity in somatic tissues, an effect associated with upregulation of TRPA1 expression and responsiveness in DRG nociceptors.

Linguoculturological aspect of studying Turkic toponyms of Crimea

The object of this research is the Turkic toponymic units of the Crimean Region. The subject of this research is the Crimean Tatar toponymic lexicon in the linguocultural aspect. The article examines the Turkic (Crimean Tatar) toponymic system as a fragment of the linguistic worldview of its native speakers. The need is underlined for comprehensive characteristics of geographical denominations of the Crimean Peninsula, with consideration of linguoculturological components as a full-fledged element. The goal consists in description of the Turkic toponymic units of Crimean Region as a phenomenon generated by the culture of Crimean Tatars. It is determined that the semantic of Turkic toponyms is motivated by different associations related to images of the animals and their habitat, plants, historical events and legends that defined names of the objects, etc. There also nomens with unmotivated semantics, permitting variable semantization. As a result of analysis, the examined in linguoculturological aspect toponyms of Crimea of Turkic origin are classified by most significant thematic groups. The Crimean Tatar toponymic lexicon is viewed from linguoculturological perspective for the first time, which defines the scientific novelty of the research. The following conclusions were made: geographical denominations of Crimea are the cultural artifact of Crimean Tatars, reflecting the historical stages of their settlement, ancient migrations and interethnic contacts, economic activity. Political and social transformations, geographical specificities, location, territorial traditions, including those that no longer exist.  The geographical nominations, alongside the instances of creation of toponyms based on external resemblance of geographical object with the realities surrounded Crimean Tatars (color, form), also used cultural and mental associative principles of nomination. This is why the terms included religious, somatic, legend-based, and other components.