Inverse problems in biomedical image analysis represent a significant frontier in disease detection, leveraging computational methodologies and mathematical modelling to unravel complex data embedded within medical images. These problems include deducing the unknown properties of biological structures or tissues from the observed imaging data, presenting a unique challenge in decoding intricate biological phenomena. Regarding disease detection, this technique has played a critical role in optimizing diagnostic efficiency by extracting meaningful insights from different imaging modalities like molecular imaging, MRI, and CT scans. Inverse problems contribute to uncovering subtle abnormalities by employing iterative optimization techniques and sophisticated algorithms, enabling precise and early disease detection. Deep learning (DL) solutions have emerged as robust mechanisms for addressing inverse problems in biomedical image analysis, especially in disease recognition. Inverse problems involve reconstructing unknown structures or parameters from observed data, and the DL model excels in learning complex representations and mappings. This study develops a DL Solution for Inverse Problems in the Advanced Biomedical Image Analysis on Disease Detection (DLSIP-ABIADD) technique. The DLSIP-ABIADD technique exploits the DL approach to solve inverse problems and detect the presence of diseases on biomedical images. To solve the inverse problem, the DLSIP-ABIADD technique uses a direct mapping approach. Bilateral filtering (BF) is used for image preprocessing. Besides, the MobileNetv2 model derives feature vectors from the input images. Moreover, the Henry gas solubility optimization (HGSO) method is applied for optimal hyperparameter selection of the MobileNetv2 model. Furthermore, a bidirectional long short-term memory (BiLSTM) model is deployed to identify diseases in medical images. Extensive simulations have been involved to illustrate the better performance of the DLSIP-ABIADD technique. The experimentation outcomes stated that the DLSIP-ABIADD technique performs better than other models.