Solubility Parameter Of Solvent Research Articles

Assembled Monolayers of Hydrophilic Particles on Water Surfaces

A facile and quick approach to prepare self-assembled monolayers of water-dispersible particles on the water surface is presented. Particle suspensions in alcohols were dropped on a water reservoir to form long-range ordered monolayers of various particles, including spherical solid particles, soft hydrogel particles, metal nanoparticles, quantum dots, nanowires, single-wall carbon nanotubes (SWCNTs), nanoplates, and nanosheets. A systematic study was conducted on the variables affecting the monolayer assembly: the solubility parameter of spreading solvents, particle concentration, zeta potential of the particles in the suspension, surface tension of the water phase, hardness of the particles, and addition of a salt in the suspension. This method requires no hydrophobic surface treatment of the particles, which is useful to exploit these monolayer films without changing the native properties of the particles. The study highlights a quick 2D colloidal assembly without cracks in the wafer scale as well as transparent conductive thin films made of SWCNTs and graphenes.

Infinite dilution partition coefficients of benzene derivative compounds in supercritical carbon dioxide + ionic liquid systems: 1-butyl-3-methylimidazolium chloride [bmim][Cl], 1-butyl-3-methylimidazolium acetate [bmim][Ac] and 1-butyl-3-methylimidazolium octylsulfate [bmim][OcSO4

Infinite dilution partition coefficients of benzene and benzene derivative compounds (chlorobenzene, bromobenzene, toluene, ethylbenzene, benzaldehyde, benzyl alcohol and phenol) between supercritical carbon dioxide and ionic liquids (1-butyl-3-methylimidazolium chloride [bmim][Cl], 1-butyl-3-methylimidazolium acetate [bmim][Ac] and 1-butyl-3-methylimidazolium octylsulfate [bmim][OcSO4]) were measured with a packed-column chromatographic technique. The Sanchez–Lacombe equation of state was used to correlate the data and could describe the qualitative changes of the infinite dilution partition coefficients over a wide range of temperatures (313–352K) and pressures (5–15MPa). A linear solvation energy relationship (LSER) model, LSER-δ, was developed for compressible phases that uses solute, solvent and ionic liquid solubility parameters. Partition coefficients were generally in the order of solute volatility with the exception of hydrogen bonding solutes. LSER solute volume (McGowan's volume, V) and solute dipolarity/polarizability (S) greatly affected the partition coefficient values. It was found that the McGowan's volume can be considered as a function of the CO2 solubility parameter, which may be helpful in extending LSER theory to supercritical fluid systems. Both models could describe the partition coefficient well and were useful in understanding some of the interactions of the solute with the supercritical CO2 and ionic liquid phases.

Matrix-assisted pulsed-laser evaporated polymer films in all-organic field-effect transistors and metal–insulator–semiconductor diodes

The electrical properties of matrix-assisted pulsed-laser evaporated (MAPLE) 9,9-dioctylfluorene-co-bis-N-N-(4-butylphenyl)-bis-N,N-phenyl 1,4-phenylenediamine (PFB)-based bottom-gate organic field-effect transistors (FETs) and metal–insulator–semiconductor (MIS) diodes with poly (methyl methacrylate) (PMMA) as the dielectric layer have been investigated. The device characteristics were found to improve with an increase in the difference between the solubility parameters of PMMA and solvent. Shifts in flat band voltage of the MIS diodes were found to be due to the difference in the density of trapped holes located at the semiconductor–insulator interface. The threshold voltage of the FETs were correlated with differences in acceptor doping density and flat band voltage shifts of the MIS diodes, thereby demonstrating the role of interface traps in determining the electrical properties of organic devices. Electrical characterization of the FET shows the device to have a hysteresis-free operation in its transfer characteristics, a low threshold voltage of −0.2 V, and a field-effect mobility of 0.2 × 10 −4 cm 2 V −1 s −1. Interface trap states of the MIS diodes were found to be distributed in energy with their density decreasing non-linearly from approximately 2.8 × 10 12 to 1.2 × 10 12 eV −1 cm −2 over an energy range of 0.075–0.385 eV above the bulk Fermi level. Non-orthogonality of the semiconductor solvent had no deleterious effects on the underlying PMMA dielectric layer even without any high temperature baking, thus demonstrating that MAPLE is a viable technique for fabricating polymer dielectric-based devices and for improving the semiconductor–insulator interface.

Separation of bioactives from seabuckthorn seeds by supercritical carbon dioxide extraction methodology through solubility parameter approach

Seabuckthorn ( Hippophae rhamnoids L.) seed oil having high nutraceutical, cosmeceutical and therapeutic activity has been extracted from dried seabuckthorn (SBT) seed powder using supercritical carbon dioxide (SC-CO 2). The solubility parameter of SBT actives (tocopherols, lycopene and β-carotene), CO 2, and entrainer solvents was calculated and validated with experimental results. The free radical scavenging activity of the extract was evaluated in terms of DPPH assay. Theoretically, pressure and temperature had significant effect on extraction of SBT actives. A maximum recovery of 77.2% tocopherol, 75.5% carotene and an EC 50 of 49.9 mg/mL (from DPPH assay) was obtained after SC-CO 2 extraction at 35 °C, 400 bar and run time of 60 min. Further optimization of the extraction conditions by Box–Behnken design increased the extraction efficiency. Use of 2-propanol as an entrainer at 30% v/w of dried SBT seed powder at optimized conditions showed a recovery of tocopherols and carotenes of 91.1% and 69.6%, respectively, while it showed EC 50 of 38.9 mg/mL. The optimized conditions were a temperature of 35 °C, pressure of 305 bar and run time of 90 min.

Solubility prediction of satranidazole in propylene glycol-water mixtures using extended hildebrand solubility approach

Extended Hildebrand solubility approach is used to estimate the solubility of satranidazole in binary solvent systems. The solubility of satranidazole in various propylene glycol-water mixtures was analyzed in terms of solute-solvent interactions using a modified version of Hildebrand-Scatchard treatment for regular solutions. The solubility equation employs term interaction energy (W) to replace the geometric mean (δ1δ2), where δ1 and δ2 are the cohesive energy densities for the solvent and solute, respectively. The new equation provides an accurate prediction of solubility once the interaction energy, W, is obtained. In this case, the energy term is regressed against a polynomial in δ1 of the binary mixture. A quartic expression of W in terms of solvent solubility parameter was found for predicting the solubility of satranidazole in propylene glycol-water mixtures. The expression yields an error in mole fraction solubility of ~3.74%, a value approximating that of the experimentally determined solubility. The method has potential usefulness in preformulation and formulation studies during which solubility prediction is important for drug design.

Extended hildebrand solubility approach: satranidazole in mixtures of dioxane and water.

The extended Hildebrand solubility parameter approach is used to estimate the solubility of satranidazole in binary solvent systems. The solubility of satranidazole in various dioxane-water mixtures was analyzed in terms of solute-solvent interactions using a modified version of Hildebrand-Scatchard treatment for regular solutions. The solubility of satranidazole in the binary solvent, dioxane-water shows a bell-shaped profile with a solubility maximum well above the ideal solubility of the drug. This is attributed to solvation of the drug with the dioxane-water mixture, and indicates that the solute-solvent interaction energy is larger than the geometric mean (δ1δ2) of regular solution theory. The new approach provides an accurate prediction of solubility once the interaction energy is obtained. In this case, the energy term is regressed against a polynomial in δ1 of the binary mixture. A quartic expression of W in terms of solvent solubility parameter was found for predicting the solubility of satranidazole in dioxane-water mixtures. The method has potential usefulness in preformulation and formulation studies during which solubility prediction is important for drug design.

Enthalpy-Entropy Compensation and Solubility Parameters for Solutions of Nonmesomorphic Solutes in the Smectic-A, Nematic and Isotropic Phases of the Liquid Crystal p-n-octyl-p′-cyanobiphenyl

Ratios of infinite dilution solute activity coefficients (\(\gamma_{2}^{\infty} )\) for nonmesomorphic solutes at the smectic-A-to-nematic (\(\gamma_{2,\mathrm{SA}}^{\infty}/\gamma_{2,\mathrm{N}}^{\infty} )\) and the nematic-to-isotropic (\(\gamma_{2,\mathrm{N} '}^{\infty} /\gamma_{2,\mathrm{I}}^{\infty} )\) phase transition temperatures, \(T_{\mathrm{S}\mbox{\scriptsize--}\mathrm{N}}\) and \(T_{\mathrm{N} \mathrm{'}\mbox{\scriptsize--}\mathrm{I}}\) respectively, of p-n-octyl-p′-cyanobiphenyl (8CB) show that the solutes are more soluble in the isotropic phase than in the smectic-A and nematic phases where they exhibit a nearly equal solubility. The Flory-Huggins size effect correction (\(\gamma_{\mathrm{F}\mbox{\scriptsize--}\mathrm{H}}^{\infty} )\), and the thermal (\(\gamma_{\mathrm{T}}^{\infty} )\) and athermal (\(\gamma_{\mathrm{I}\mbox{\scriptsize--}\mathrm{S}}^{\infty} )\) contributions to \(\gamma_{2}^{\infty}\), are evaluated. Solute partial molar enthalpies (ΔsolvH) and entropies (ΔsolvS) of solvation show a compensation effect that reflects a delicate interplay between solute-solvent interactions and size and structure effects. Both the solute and solvent solubility parameters, δ2 and δ1 respectively, decrease as temperature increases. Additionally the δ1 values undergo a discontinuous increase at \(T_{\mathrm{S}\mbox{\scriptsize--}\mathrm{N}}\) attributed to the disappearance of the layered structure of the Smectic-A phase and a discontinuous decrease at \(T_{\mathrm{N}'\mbox{\scriptsize--}\mathrm{I}}\) attributed to an increase in the flexibility of the alkyl tails of the liquid crystal molecules in the nematic phase. Evidence that hints at the effect of the structure of the liquid crystal solvent on the solution process is presented.

Probe dependency of segmental interaction parameters in copolymers by inverse gas chromatography

Inverse gas chromatography (IGC) has been widely used to determine the Flory-Huggins parameter, χ, between two polymers using a series of solutes as probes. Many studies showed that interaction parameters were probe dependent. In recent studies, it was proposed that the difference in interaction energy between functional groups of solutes and solvent mixtures could lead to an apparent solvent solubility parameter different from the volume average of the components. An equation was derived to relate the probe dependency to the deviation of the solubility parameter. By plotting ϕ2ϕ3RT(χ23/V2) vs. the solubility parameter of solutes, a straight line could be obtained with a slope proportional to the deviation of the solvent solubility parameter. The plot was shown to yield negative slopes for miscible polymer blends. When there was an unfavorable interaction between two solvents, an opposite situation would be observed. In this study, the method was tested in two copolymer systems, and the copolymers were considered as mixtures of two homopolymers. The plots showed straight lines with positive slopes when χ23 was positive. The technique was shown to apply to copolymer systems also. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011

Design of nonaqueous polymer gels with broad temperature performance: Impact of solvent quality and processing conditions

Polymer gels have potential use for a wide variety of applications, primarily due to the ability to tailor the gel properties by varying several material parameters. While substantial attention has focused on water-based hydrogels, the use of these materials is limited due to a narrow operational temperature range. This report describes a nonaqueous polymer gel, composed of a cross-linked polybutadiene network swollen with low volatility polymer plasticizers. Thermal, mechanical, and adhesive characterization illustrated that the gels exhibit performance over an extremely broad temperature range (−60–70 °C). Solvent quality and loading played a critical role in the operational temperature window with small solvent solubility parameter deviations dramatically reducing the operational temperature range. In addition, the processing conditions had a large impact on the gel mechanical properties. As a result, it is important to consider the influence of processing conditions and solvent quality when tailoring polymer gels for practical applications.

Systematic Study of the Dispersion of SWNTs in Organic Solvents

Dispersions of as-produced HiPco single-walled carbon nanotubes (SWNTs) in a series of organic solvents were prepared by dilution with the aid of tip sonication. Mild centrifugation (∼945 g) was carried out to remove large bundles. Atomic force microscopy (AFM) studies revealed that the bundle size decreased as the dispersion was diluted. By measuring the UV−vis−NIR absorption before and after centrifugation as a function of the concentration, the dispersion limit of SWNTs in each solvent can be determined. Correlations between the dispersion limit and solvent solubility parameters, including the Hildebrand solubility parameter and three-dimensional Hansen solubility parameters, are explored, demonstrating that SWNTs are easily dispersed in solvents with Hildebrand solubility parameter range from ∼22−24 MPa1/2 and Hansen polarity component (δP) ∼12−14 MPa1/2. No clear correlation between dispersion limits and the dispersion force (δD) or hydrogen bonding force (δH) are evident. It is found, however, that the degree of dispersion depends critically on sample preparation conditions and in particular sonication time. Increased sonication times increase the amount of SWNTs debundled and solubilized but do not appear to affect the dispersion limit. However, increased sonication also induces discernible changes to the SWNTs themselves and in itself influences their solubility, under which conditions no clear solubility parameters can be determined.

Wetting, Swelling and Redispersion Characteristics of Green Sheets on Various Solvents

Wetting, swelling and redispersion characteristics of green sheets on water and four organic solvents were investigated. Those solvents are different in solubility parameters, index numbers of solvent evaporation rate, viscosities and interfacial tensions. Contact angle correlation with interfacial tension of solvents corresponded with wetting theory in the case of polymer film. In contrast, in the case of green sheet, contact angle and distance travelled by solvent front were not only related with interfacial tension. As the difference of the value of solubility parameter of solvent and that of polymer decreases, an expanse of a solvent to the green sheet surface decreases and a swelling characteristics of green sheet in the solvent increases except experiments with dioctyl phthalate and water. These results are discussed on the base of solvent characteristics and green sheets characteristics.

Effects of mixed solvents and PVDF types on performances of PVDF microporous membranes

AbstractPolyvinylidene fluoride (PVDF) microporous flat membranes were cast with different kinds of PVDFs and four mixed solvents [trimethyl phosphate (TMP)–N,N‐dimethylacetamide (DMAc), triethyl phosphate (TEP)–DMAc, tricresyl phosphate (TCP)–DMAc, and tri‐n‐butyl phosphate (TBP)–DMAc]. The effects of different commercial PVDFs (Solef® 1015, FR 904, Kynar 761, Kynar 741, Kynar 2801) on membrane morphologies and membrane performances of PVDF/TEP–DMAc/PEG200 system were investigated. The membrane morphologies were examined by scanning electron microscopy (SEM). The membrane performances in terms of pure water flux, rejection, porosity, and mean pore radius were measured. The membrane had the high flux of 143.0 ± 0.9 L m−2 h−1 when the content of TMP in the TMP–DMAc mixed solvent reached 60 wt %, which was 2.89 times that of the membrane cast with DMAc as single solvent and was 3.36 times that of the membrane cast with TMP as single solvent. Using mixed solvent with different solvent solubility parameters, different morphologies of PVDF microporous membranes were obtained. TMP–DMAc mixed solvent and TEP–DMAc mixed solvent indicated the stronger solvent power to PVDF due to the lower solubility parameter difference of 1.45 MPa1/2 and the prepared membranes showed the faster precipitation rate and the higher flux. The less macrovoids of the membrane prepared with TEP (60 wt %)–DMAc (40 wt %) as mixed solvent contributed to the higher elongation ratio of 96.61% ± 0.41%. Therefore, using TEP(60 wt %)–DMAc (40 wt %) as mixed solvent, the casting solution had the better solvent power to PVDF, and the membrane possessed the excellent mechanical property. The microporous membranes prepared from casting solutions with different commercial PVDFs exhibited similar morphology, but the water flux increased with the increment of polymer solution viscosity. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2010

Qualitative separation of the effect of the solubility parameter on the recovery behavior ofshape-memory polymer

For the thermal response of shape-memory polymer (SMP) it has been experimentallydemonstrated that the actuation can be achieved using interactive solvent. In this paper,the effect of the solubility parameter of the interactive solvent on the shape recoverybehavior and glass transition temperature of polystyrene SMP was investigatedexperimentally. The effect of the solubility parameter on the activation energy wasseparated and qualitatively identified, as expected from the relaxation theory and Eyringequation. This approach should be applicable to other SMPs and their composites andmany extension applications and achievements could be based on this outcome.

Comparison of pressure driven transport of ethanol/ n-hexane mixtures through dense and microporous membranes

The solvent flux was measured in binary mixtures of ethanol and n-hexane for nine solvent-stable polymeric membranes in range of reverse osmosis (RO) to ultrafiltration (UF) (GE AK Osmonics, Dow 102326, GE DK Osmonics, MPF-34, STARMEM™ 122, STARMEM™ 240, NF30, NTR7450, NF-PES-010). GC-analyses of feed and permeate samples showed a separation factor close to 1, which indicates the solvent transport occurs by convection or by coupled diffusion through the membranes. The effect of viscosity, surface tension, di-electric constant and solubility parameter of solvent on permeation rate was studied for four categories of membranes, i.e. RO membranes, dense nanofiltration (NF) membranes, semi-porous NF membranes and micro-porous NF membranes. While viscosity seems to be a main transport parameter (similar composition of feed and permeate), higher fluxes of ethanol compared to n-hexane (with lower viscosity) confirmed that the transport may occur through coupled diffusion. The influences of the solvent–membrane interaction parameters such as surface tension, polarity and solubility parameters of solvent and membranes for dense membranes were investigated. The effect of solvent membrane interaction by means of solubility parameters was more pronounced compared to surface tension since the respective surface tensions of solvents are close to one another ( γ ethanol = 21.9 , γ n ‐ hexane = 17.9 ) . Partial permeabilities were studied as well to evaluate the influence of each component on permeation of the other. Unexpected results were observed for MPF-34, NF30 and NTR7450. Further investigation confirmed that their polymeric structure changed in contact with the solvents. Hydrophobic STARMEM™ membranes, which are expected to have a higher permeability for apolar solvents showed higher fluxes for ethanol compared to n-hexane. The similar solubility parameter of these membranes and ethanol may increase the permeation rate of ethanol molecules through membranes. For porous membranes viscosity was recognized as the key transport parameter, while affinity between membrane and solvent has a lower effect.

고분자 용액에서 침점중합에 의한 P(PEGMA-co-PBMA) 마이크로젤의 합성

Poly(ethyleneglycol methacrylate-co-benzyl methacrylate) (P(PEGMA-co-BMA) 마이크로겔을 폴리아크릴산 용액에서 PEGMA와 벤질 메타아크릴레이트를 침전중합법으로 합성하였다. 다양한 입자 크기를 갖는 마이크로겔은 폴리아크릴산 및 모노머의 농도, 용매의 성질에 따라 합성하였다. P(PEGMA-co-BMA) 마이크로겔의 입자 크기는 폴리아크릴산의 농도가 증가할수록 감소하였고 모노머의 농도가 증가할수록 증가하였다. 또한 용매의 용매 파라메타의 값이 증가할수록 입자의 크기는 증가하였다. 그리고 P(PEGMA-co-BMA) 마이크로겔의 크기는 실험 조건에 따라 <TEX>$0.1{\mu}m$</TEX>에서 <TEX>$0.35{\mu}m$</TEX>까지 조절할 수 있었다. Poly(ethyleneglycol methacrylate-co-benzyl methacrylate) (P(PEGMA-co-BMA)) microgel was prepared by precipitation copolymerization of PEGMA and benzyl methacrylate in poly(acrylic acid)/ethanol solution. The microgels with various sizes were obtained by changing the concentration of poly(acrylic acid), monomer and nature of solvents. The particle size of P(PECMA-co-BMA) microgels was decreased with increasing the concentration of poly(acrylic acid) and increased with that of monomer. By increasing solubility parameter of solvents, the particle size was inecreased. The size of P(PEGMA-co-BMA) microgels was controlled by experimental conditions from <TEX>$0.1{\mu}m$</TEX> to <TEX>$0.35{\mu}m$</TEX>.

Investigation of liquid sensing mechanism of poly(lactic acid)/multi-walled carbonnanotube composite films

The liquid sensing mechanism of melt-processed poly(lactic acid) (PLA)/multi-walledcarbon nanotube (MWNT) composite films was investigated for the influence of MWNTloading, solubility parameters of solvents used, solvent transport behaviours, resultantelectrical resistance changes, as well as crystallization of the PLA matrix. Thediffusion, sorption and permeation coefficients of neat PLA and the composites wereestimated, indicating that MWNT network structures block solvent moleculesfrom penetrating into the polymer matrix. Solvent-induced crystallization of thepolymer matrix was observed. Isothermally crystallized composites showed reducedresistances, a significant decrease of sorbed solvent content and a reduction of theresulting resistance changes on the solvent contact. In the context with sensingresults on MWNT mats, it was proposed that the liquid sensing mechanism ofPLA/MWNT composites consists of the overall electrical resistance changes causedby the structural variation of the conductive MWNT network in the polymermatrix and additional interactions between the MWNT and solvent molecules.

Interpretation of CO2 Solubility and Selectivity in Nitrile-Functionalized Room-Temperature Ionic Liquids Using a Group Contribution Approach

In this work, tuning the solubility parameter of room-temperature ionic liquids (RTILs) with appended functional groups was explored using a combination of experiment and theory. By predictably altering the solubility parameters of several RTIL solvents, their gas solubility and separation performance were tailored. This concept was demonstrated by synthesizing and characterizing imidazolium-based RTILs that incorporate nitrile and alkyne functional substituents. The ideal solubility and selectivity values of CO2, N2, and CH4 at near ambient temperature and pressure were measured for these RTILs. These functionalized RTIL solvents exhibited lower CO2, N2, and CH4 solubility values but improved CO2/N2 and CO2/CH4 solubility selectivity when compared to analogous nonfunctionalized, n-alkyl-substituted RTILs. A group contribution method was used to predict the solubility parameters of the functionalized RTILs, and these values were used with regular solution theory to predict the solubility and selectivity of the three gases. These predicted gas solubility values were found to be in good agreement with those measured experimentally. Furthermore, the predictions from the group contribution method indicated that inclusion of the nitrile and alkyne functional groups increased the solubility parameter relative to the analogous, n-alkyl-substituted RTILs. These initial results show that the group contribution method offers a valuable guide for systematically designing functionalized RTILs with specific gas solubility and selectivity performance.

Polymer vs Solvent Diagram of Film Structures Formed in Spin-Cast Poly(3-alkylthiophene) Blends

A polymer vs solvent diagram of film structures, formed in polystyrene (PS) blends (1:1 w:w PS/PT) with poly(3-alkylthiophenes) PT [regioregular R-P3DDT, R-P3HT and regiorandom P3BT, P3DDT] spin-coated onto oxidized silicon surfaces from various common solvents [p-xylene, toluene, chloroform, chlorobenzene, cyclohexanone] is presented. The structures were determined with microscopic techniques (atomic, AFM and lateral, LFM, force microscopy, fluorescent microscopy FM) and dynamic secondary ion mass spectrometry (dSIMS). The diagram, arranged according to the solubility parameter of the PTs and the solvents, exhibits three main structural classes: dewetting, lamellar, and lateral (quasi-2-dim) morphology. Decrease in PT solubility parameter δPT inhibits dewetting of polymer films. It induces also a transition from lamellar to lateral film structure. Increase in solvent solubility parameter δS has similar effects. Such behavior is related to the stability of transient homogeneous films and multilayers in the course of spin-casting. The role of δPT and δS is elucidated based on the stability analysis performed in terms of spreading coefficient (dependent on δPT) and effective interfacial tension of solvent-rich polymer phase (dependent on δS).

Investigation of the selection of extraction solvent for extracting the n-alkane from diesel by means of solubility parameters theory

The solubility parameters (including dispersion coefficient δ d, polarity δ p, and hydrogen bonding δ h) of extraction solvents (like ketones, chlorinated hydrocarbon, ester, alcohol, and ether) and diesel oil components ( n-alkanes and aromatics) were estimated by using the group contribution method. The relationship between the solubility parameters of the solvent and the extraction efficiency of n-alkane from diesel oil was investigated. The results illustrated that the larger the difference between the solvent and n-alkane in the solubility parameters is, the higher is the extraction ratio, for the solvents except alcohols. Nonalkane content of waxpaste removed by the solvents with a dispersion contribution ( f d ) of higher than two-thirds was much less than that by the solvents with a lower f d.

Narrowly dispersed molecularly imprinted microspheres prepared by a modified precipitation polymerization method

A modified precipitation polymerization (MPP) method was established to prepare narrowly dispersed molecularly imprinted polymeric microspheres. MPP was stabilizer and surfactant free and needed only small amount of porogen (about 50 wt.%). Only part of alcohols and all the alkanes tested formed particles. Using a mixture of alkane and toluene as porogen, the carbon numbers of alkanes and solubility parameter of porogenic solvents were important factors in controlling particle morphology. Nearly mono-dispersed microspheres with diameter of about 2–3 μm were synthesized by MPP using mineral oil:toluene = 2:3 as porogen. Template did not affect the formation of globe microspheres in MPP. Microspheres prepared under the lowest reaction temperature had the highest binding capability. When used as sorbents of high performance liquid chromatography (HPLC), the microspheres prepared by MPP using bisphenol A, estradiol, and tebuconazole as template had similar binding selectivity and higher binding capability compared to microspheres synthesized by classical precipitation polymerization. Photoinitiation and low reaction temperature were important factors attributed to better binding capability of microspheres prepared by MPP.