This study proposes a systematic approach to address ergonomic factors, including physical, environmental and psychosocial aspects, in solving assembly line balancing problems. A three-stage framework is developed, starting with determining weights for ergonomic risk assessment methods using the interval-valued spherical fuzzy analytical hierarchy process. In the second stage, a fuzzy logic model for integrated ergonomic risk assessment is constructed based on these weights, and the integrated ergonomic risk score is determined. In the third stage, a mathematical model is formulated to minimise the cycle time while balancing the ergonomic risk level. A case study conducted in a wire harness factory validated the effectiveness of the proposed approach, showing a 10–11% improvement in line efficiency and a 12–25% enhancement in ergonomic risk balancing performance. These findings underscore the potential benefits of implementing this approach, which can significantly improve occupational safety and overall performance.