Abstract In this article, we consider the global and local well-posedness of the mild solutions to the Cauchy problem of fractional drift diffusion system with higher-order nonlinearity. The main difficulty comes from the higher-order nonlinearity. Instead of the convention that people always focus on the properties of the solution in critical spaces, here we are interested in non-critical spaces such as supercritical Sobolev spaces and subcritical Lebesgue spaces. For the initial data in these non-critical spaces, using the properties of fractional heat semigroup and the classical Hardy-Littlewood-Sobolev inequality, we obtain the existence and uniqueness of the mild solution, together with the decaying rate estimates in terms of time variable.
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