Four formulas of granules with caffeine were chosen to examine the influence of excipients on dissolution profiles of active substance from this drug form. The formula I: caffeine 1.0 parts, potato starch 69,3 parts, lactose 29,7 parts, glycerol 86% 2.0 parts, gelatin mucilage 4% (w/w) 98.0 parts; the formula II: caffeine 1.0 parts, Avicel 49,5 parts, lactose 49,5 parts, glycerol 86% 2.0 parts, gelatin mucilage 4% (w/w) 98.0 parts; the formula III: caffeine 1.0 parts, D-Mannitol 99,0 parts, glycerol 86% 2.0 parts, gelatin mucilage 4% (w/w) 98.0 parts and the formula IV: caffeine 1.0 parts, Avicel 49,5 parts, lactose 49,5 parts, and 0.5% solution of PVP 100.0 parts. This solution was prepared by dissolution of 0.5 parts PVP in 95.5 parts of mixture of ethanol 96° and water 1:1 (w/w). The granules were obtained in wet granulator. Their flow properties, moisture content, disintegration time and dissolution of active substance were tested. All granules passed the pharmacopoeial dissolution test because 80% of caffeine dissolved in 10 minutes time.