Glycine Solution Research Articles

Solvation properties of 1-butyl 2, 3-dimethyl imidazolium chloride ionic liquid in aqueous and aqueous glycine solutions at different temperatures using volumetric and compressibility parameters

Volumetric and compressibility approaches were employed in this investigation to analyse the intermolecular interactions of 1-Butyl-2,3-dimethyl imidazolium chloride in aqueous, in 0.05 mol.kg−1 aqueous glycine and 0.1095 mol.kg−1 aqueous glycine solutions over the concentration range 0.01 to 0.13 mol.kg−1 at different temperatures i.e., T= (288.15,293.15, 298.15, 303.15, 308.15, 313.15 and 318.15) K and atmospheric pressure by measuring density(ρ) and speed of sound(u) data. Various thermophysical parameters such as apparent molar volume of solute(Vϕ), limiting apparent molar volume of solute(Vϕ0), transfer limiting apparent molar volume of soluteΔtrVϕ0, Hepler's constant (∂2Vϕ0/∂T2), isentropic compressibility (κS), apparent molar isentropic compression of solute (KS,ϕ), partial molar isentropic compression of solute(KS,ϕ0) and partial molar isentropic compression of transfer of solute ΔtrKS,ϕ0 have been calculated using the corresponding thermophysical data at studied temperatures. In addition, the temperature dependence of apparent molar volume of solute has been used to determine isobaric expansivity or thermal expansion coefficient(α), apparent molar expansivity of solute Eϕ and limiting apparent molar expansivity solute Eϕ0 parameters of binary and ternary systems. The findings were described in terms of solute–solute and solute–solvent interactions.

A new fibrillization mechanism of β-lactoglobulin in glycine solutions

Even though amyloid aggregates were discovered many years ago the mechanism of their formation is still a mystery. Because of their connection to many of untreatable neurodegenerative diseases the motivation for finding a common aggregation path is high. We report a new high heat induced fibrillization path of a model protein β-lactoglobulin (BLG) when incubated in glycine instead of water at pH 2. By combining atomic force microscopy (AFM), transmission emission microscopy (TEM), dynamic light scattering (DLS) and circular dichroism (CD) we predict that the basic building blocks of fibrils made in glycine are not peptides, but rather spheroid oligomers of different height that form by stacking of ring-like structures. Spheroid oligomers linearly align to form fibrils by opening up and combining. We suspect that glycine acts as an hydrolysation inhibitor which consequently promotes a different fibrillization path. By combining the known data on fibrillization in water with our experimental conclusions we come up with a new fibrillization scheme for BLG. We show that by changing the fibrillization conditions just by small changes in buffer composition can dramatically change the aggregation pathway and the effect of buffer shouldn't be neglected. Fibrils seen in our study are also gaining more and more attention because of their pore-like structure and a possible cytotoxic mechanism by forming pernicious ion-channels. By preparing them in a simple model system as BLG we opened a new way to study their formation.

Molecular Dynamics Investigation of Clustering in Aqueous Glycine Solutions.

Recent experiments with undersaturated aqueous glycine solutions have repeatedly exhibited the presence of giant liquid-like clusters or nanodroplets around 100 nm in diameter. These nanodroplets re-appear even after careful efforts for their removal and purification of the glycine solution. The composition of these clusters is not clear, although it has been suggested that they are mainly composed of glycine, a small and very soluble amino acid. To gain insights into this phenomenon, we study the aggregation of glycine in aqueous solutions at concentrations below the experimental solubility limit using large-scale molecular dynamics simulations under ambient conditions. Three protonation states of glycine (zwitterion = GLZ, anion = GLA, and cation = GLC) are simulated using molecular force fields based on the 1.14*CM1A partial charge scheme, which incorporates the OPLS all-atom force field and TIP3P water. When initiated from dispersed states, we find that giant clusters do not form in our simulations unless salt impurities are present. Moreover, if simulations are initiated from giant cluster states, we find that they tend to dissolve in the absence of salt impurities. Therefore, the simulation results provide little support for the possibility that the giant clusters seen in experiments are composed purely of glycine (and water). Considering that strenuous efforts are made in experiments to remove impurities such as salt, we propose that the giant clusters observed might instead result from the aggregation of reaction products of aqueous glycine, such as diketopiperazine or other oligoglycines which may be difficult to separate from glycine using conventional methods, or their co-aggregation with glycine.

Glycine leaching kinetics of chalcocite in alkaline medium in the presence of hydrogen peroxide

The leaching of copper-containing raw materials with environmentally friendly reagents under near-environmental conditions is an important problem of modern hydrometallurgy. In this regard this article presents kinetic regularities of leaching of sulfide mineral – chalcocite (Cu2S) using the simplest amino acid – glycine (Gly) in alkaline medium at 25 ºС. It is assumed that the leaching is mainly due to complexation of copper (II) glycinates. The influence of different parameters on the amino acid leaching process such as concentrations of glycine, sodium hydroxide, hydrogen peroxide, reagent ratio and duration of the experiment were studied. The results of atomic absorption analysis indicated a significant increasing of copper recovery efficiency from chalcocite when the oxidant hydrogen peroxide was added to the alkaline glycine solution system. After 30 minutes the degree of copper recovery has reached 30.79 % in the system «Cu2S-0.1M Gly-0.1M NaOH-0.1M H2O2» while without hydrogen peroxide about 4 % of copper has been leached. The research results allow to recommend glycine as a promising reagent for hydrometallurgical copper production process.

Multi-technique approach to explore the mixed micellization behavior of promazine hydrochloride drug and cetyltrimethylammonium bromide surfactant in aqueous glycine, glycylglycine (dipeptide) and glycylglycylglycine (tripeptide) solutions

The aggregation properties of amphiphiles and their mixtures are of theoretical and applied importance. Therefore, mixed micellization behavior of promazine hydrochloride (PMZ) drug and cetyltrimethylammonium bromide (CTAB) surfactant at different mole fractions, α PMZ = (0.2, 0.4, 0.6 and 0.8) has been scrutinized in water and (0.025, 0.050 and 0.100) mol·kg −1 aqueous solutions of glycine, glycylglycine (dipeptide) and glycylglycylglycine (tripeptide) at T = (298.15 to 318.15) K, by means of multiple techniques. Thermodynamic parameters of micellization (ΔG°m, ΔH°m, and ΔS°m) along with excess Gibbs free energy of mixing (ΔG m ex), the molecular interaction parameter (β int), and the degree of ionization (α), have been attained from the conductivity measurements. The partial specific volumes (φ v), partial specific isentropic compression (φ κ) as well as isentropic compressibilities (κ s) were computed from the measured density and speed of sound data. UV-Visible absorption, fluorescence emission and proton (1H) NMR spectra were recorded for the pure PMZ and mixed (PMZ + CTAB) system in the presence of glycine(aq), glycylglycine(aq) and glycylglycylglycine(aq) solutions. Dynamic light scattering (DLS) study was carried out to measure the hydrodynamic diameters (D H) of mixed micellar systems. The prevalence of hydrophobic-hydrophobic interactions amid the hydrophobic groups of PMZ drug (tricyclic scaffolding), CTAB (–C16H33), glycine, di- and tri-peptides (–CH2), and electrostatic interactions amid the hydrophilic/ionic groups of PMZ{tertiary amine part and +NH (CH3)2, Cl−}, CTAB (–N (CH3)3 +, Br‒) and glycine, di- and tri-peptides {zwitterion (NH3 +, COO−} have been depicted from the aforementioned studies.

ELECTRODEPOSITION OF COBALT FROM ALKALINE GLYCINE ELECTROLYTE

This article presents a study of the electrochemical reduction of cobalt ions from an alkaline glycine electrolyte by measuring cyclic and linear potentiodynamic polar curves. In the study, a cadmium salt (CoCl2) dissolved in a 1.5 M glycine solution was used as a source of cadmium ions and the pH of the electrolyte was adjusted to the required value by adding NH4OH to the solution. By taking cyclic pola-rized curves, the range of potentials at which the reduction of cobalt ions occurs was established. The effect of cobalt concentration and temperature on the reduction process of its ions from a studied electrolyte has been studied. Finding a linear relationship between ip and ʋ1/2 established that the process of electrodeposition of cobalt ions from an alkaline glycine electrolyte is controlled by diffusion polarization, which was confirmed by the curves obtained when plotting the lgik – 1/T dependence

Trap passivation in perovskite films for improved electrical properties and charge dynamics

Perovskite films modified by a polymer will largely enhance the open circuit voltage (VOC) and cannot increase the short-circuit current (JSC) and fill factor (FF). In order to further optimize perovskite films, an ionic conducting polymer containing diblock-polymers of polyethylene oxide (PEO)150–polyphenylene oxide (PPO)30 and alkali metal salts of KBr was incorporated into perovskite films. The hydrophilic PEO blocks will coordinate with polar cations and form uniform heterostructure interfaces to passivate defects at grain boundaries (GBs). The transport of alkali metal ions in polymers will increase the conductivity of perovskite films. The synergistic effects of polymers and KBr can significantly enhance the photovoltaic response. The entirely functionalized perovskite GBs can also improve the tolerance of perovskite films against environmental stress. Aside from that, the glycine solution was deposited onto SnO2 films to passivate interface defects and further improve device performance. The improved charge transport dynamics and the suppressed charge recombination kinetics were determined using different characterization techniques. The optimized photoelectric conversion efficiency is 22.89% (a VOC of 1.166 V, a JSC of 24.30 mA cm−2, and a FF of 0.808) under a reverse scan. This work provides a feasible method to further optimize perovskite films and improve device performance.

Extraction of precious metals from waste printed circuit boards using cyanide-free alkaline glycine solution in the presence of an oxidant

Waste printed circuit boards represent one of the most challenging parts of e-waste recycling. The extraction of precious metals (gold, silver, palladium and platinum) from waste printed circuit boards has commonly been done using highly toxic, corrosive, or expensive lixiviants, such as sodium cyanide, aqua regia and iodine/iodide. The present study provides a greener approach to extract precious metals from waste printed circuit boards using alkaline glycine solution in the presence of an oxidant. The common strong oxidant of potassium permanganate and the non-hazardous potassium ferricyanide were investigated and compared in alkaline media. Decrease of the particle size of sample, and the rise of oxidant concentration (0.04–0.16 M) enhanced gold extraction significantly. However, the increase of temperature (∼55 °C) and glycine concentration (0.5–1 M), and the staged addition of oxidant did not significantly improve gold extraction. Control of solution Eh could not reduce permanganate consumption whereas the ferricyanide consumption could be reduced by>50% in 72 h. Under the recommended conditions, 86.8% gold, 70.2% silver, 89.3% palladium and 87.9% copper could be extracted using glycine-permanganate leaching system. In comparison, 79.3% gold, 69.0% silver, 68.5% palladium and 83.1% copper could be extracted using glycine-ferricyanide leaching system. These extractions are comparable with what is achievable from cyanide (NaCN)-based leaching systems. Both of the leaching systems showed fairly good selectivity to copper and precious metals. The present study paves a way for the further development of non-NaCN glycine process for e-waste recycling.

A Metastable Amorphous Intermediate Is Responsible for Laser-Induced Nucleation of Glycine.

Laser-induced crystal nucleation through optical tweezing, and in particular polymorph selection through laser polarization, promises unprecedented control over crystallization. However, in the absence of a nearby liquid-liquid critical point or miscibility gap, the origin of the required mesoscale clusters remains unclear. A number of recent studies of so-called nonclassical nucleation have suggested the presence of large amorphous clusters. Here, we show that supersaturated aqueous glycine solutions form metastable intermediate particles that are off the direct path to crystal nucleation. Laser-induced crystal nucleation only occurs when the laser "activates" one of these particles. In situ low-frequency Raman spectroscopy is used to demonstrate their amorphous or partially ordered character and transformation to various crystal polymorphs. The requirement for solution aging in many previously reported laser-induced crystal nucleation experiments strongly suggests that the presence of amorphous intermediates is a general requirement.

Preferences for different nitrogen forms in three dominant plants in a semi-arid grassland under different grazing intensities

Plant species generally absorb different nitrogen (N) forms from soil in ways that minimize N niche overlap, but whether and how grazing affects a plant’s preferred form of N remains unclear. Using the in-situ stable N isotope-labeling technique, we explored the preference of plants in taking up N of different chemical forms along an experimental gradient of grazing intensity in a semi-arid grassland in Inner Mongolia. 15N-labelled nitrate (NO3−), ammonium (NH4+) and glycine solutions were injected into the soil under nil (G0, as a control), light (G1) and heavy grazing (G2) grassland plots in June and August. Uptake of these three N forms was determined for three dominant plants, Leymus chinensis, Stipa grandis and Cleistogenes squarrosa. L. chinensis had the highest N acquisition capacity. Regardless of species, N absorption was higher in August than in June. While all three plant species absorbed glycine-N, they preferentially absorbed N in its inorganic forms (NO3−-N + NH4+-N), with NO3−-N having the highest uptake. Irrespective of grazing intensity, during peak growth (August) all three plant species preferred to absorb NO3−-N (the dominant N form) than NH4+-N or glycine-N. In contrast, in June plants differed in their preferred form of N uptake depending on the grazing treatment. Under heavy grazing (G2), all plants preferentially absorbed NO3−-N. Under light grazing (G1), all plants absorbing all three N chemical forms with no significant difference. Under no grazing (G0), L. chinensis preferentially absorbed NO3−-N but otherwise there was no significant effect of grazing intensity on the preferred form of N. Our results indicate that the three species of plants that we observed altered their N-uptake preference in response to grazing intensity differently in the early growth and vigorous growth stages. Plant N niche differentiation in time, space and chemical N forms needs to be explored systematically in future studies to aid understand of grazing effects on N processes in grassland ecosystem.

Glycine-mediated leaching-mineralization cycle for CO2 sequestration and CaCO3 production from coal fly ash: Dual functions of glycine as a proton donor and receptor

The state-of-the-art CO2 mineralization technologies involved Ca/Mg leaching and ensued mineralization still struggle with the slow reaction kinetics and frequent pH swings assisted by exogenous chemicals consumption (i.e., low pH for Ca/Mg leaching but high pH for CO2 dissolution and solid carbonates precipitation). This study proposed a glycine-mediated leaching-mineralization cycle (LMC) process, which can simultaneously achieve promising Ca/Mg leaching efficiency, high mineral carbonation efficiency, and production of high-purity CaCO3 from coal fly ash (CFA) at mild operating conditions in an in-situ recyclable amino acid solution. The technical feasibility of the process was initially investigated in individual leaching and mineral carbonation experiments in glycine (Gly0) solutions using a typical CFA. A Ca2+ leaching efficiency of 42.17% and a CaCO3 yield of 89.10 g/kg were achieved in the Gly0 solution. Mineralogy and morphology analysis revealed that the CaCO3 obtained after the carbonation reaction was mainly present as vaterite. The mechanism exploration revealed that Gly-species acted as a proton donor and chelating agent in the leaching step which enhanced the Ca2+ leaching, a proton receptor in mineralization step which accelerated CO2 mass transfer, and a crystal regulator in carbonates precipitation. In addition, the cyclic performance of the LMC process was investigated in multicycle leaching-carbonation experiments. Results showed that the leaching capacities, CaCO3 yield, and Gly0 loss were similar in five cycles of LMC experiments, verifying that the process is stable.

Volumetric, acoustic and viscometric studies of solute-solute and solute-solvent interactions of glycine and its peptides in aqueous solutions of an antidepressant drug at different temperatures

From the density (ρ), speed of sound (u) and viscosity (η) measurements, the interactions of glycine, glycylglycine and glycylglycylglycine with antidepressant drug, nortriptyline hydrochloride have been investigated in aqueous medium at temperatures, T = (293.15–313.15) K and experimental pressure p = 0.1 MPa. From the experimental density measurements, apparent molar volume (VΦ), limiting apparent molar volume (VoΦ) and partial molar volumes of transfer (VoΦ,tr) have been determined for various solutions of glycine, glycylglycine and glycylglycylglycine in aqueous nortriptyline hydrochloride. In addition, using speed of sound data, apparent molar isentropic compression (Ks,Φ), limiting apparent molar isentropic compression (Kos,Φ) and partial molar isentropic compression of transfer (Kos,Φ,tr) have been calculated. Pair and triplet interaction coefficients are also determined from VoΦ,tr values using McMillan-Mayer theory. Further, apparent molar expansibility (EoΦ) and Hepler's constant values ∂EoΦ∂TP have been evaluated to assist the interpretations earned from the volumetric and acoustic analysis. The viscosity coefficients A and B, viscosity B-coefficient of transfer (Btr) and temperature derivative of B-coefficients (dB/dT) have been determined from viscosity data. The results were interpreted in terms of different kinds of intermolecular interactions present in the ternary systems (amino acid/peptides + water + nortriptyline hydrochloride) through a cosphere overlap model. The Hepler’s constant and temperature derivative of B-coefficients (dB/dT) confirms the structure breaking nature of the solute.

An Electrokinetic Study of Amino Acid and Potential-Determining Ions for Enhanced Waterflooding in Carbonate Reservoirs

Summary Reservoir rock wettability plays an important role in waterflooding especially in fractured carbonate reservoirs because oil recovery tends to be inefficient from the mixed-wet or oil-wet rock matrix. Improved oil recovery has been observed by adjusting the concentrations of potential-determining ions (PDIs) to alter the wettability of carbonate rocks. Our previous study showed that the oil recovery from carbonate reservoirs by waterflooding can be enhanced by the addition of glycine, the simplest amino acid. The interaction of glycine anion and oil-wet carbonate surfaces was confirmed in contact angle measurements and yielded the incremental oil recovery in imbibition experiments. This paper presents a surface complexation model (SCM) for the interaction between glycine and oil-wet carbonate surfaces that considers the impact of temperature, pH, salinity, and the concentrations of PDIs. The proposed SCM was tuned based on the zeta potential (ZP) data reported for synthetic calcite in glycine solutions. The tuned model predicts that the strong affinity of glycine for the oil-wet carbonate surface causes the carboxylic acids to desorb from the surface. The concentration of adsorbed carboxylic acids was in qualitative agreement with the water-wetting state of carbonate rocks inferred from the reported contact angle and spontaneous imbibition experiments. Moreover, the model indicates that glycine’s performance as a wettability alteration agent improves significantly at high temperatures. It also suggests that enhanced oil recovery (EOR) by formation brine (FB) with 1 to 3 wt% glycine at high temperatures should be similar to the injection of low-salinity seawater (LSW). The proposed SCM supports glycine’s potential to change the wettability of oil-wet carbonates at high salinity, high hardness, and high temperature.

Leaching of thrust quartz-sulfide gold-bearing ores of Murtykta deposit using glycine solutions

Leaching of thrust quartz-sulfide gold-bearing ores of Murtykta deposit using glycine solutions

Peculiarities of mineral change under action of aqueous glycine solutions

Peculiarities of mineral change under action of aqueous glycine solutions

Leaching characterisations and recovery of copper and uranium with glycine solution of sandy dolomite, Allouga area, South Western Sinai, Egypt

ABSTRACT Copper and uranium can be recovered from the sandy dolomite ore material occurring in Um Bogma Formation, Allouga locality. The nonconventional leaching technique by glycine as lixiviant is used to avoid excessive acid consumption and safe environmentally. A technological sample assays 25 g/kg Cu and 0.6 g/kg U had been processed. Under optimum leaching conditions using 0.2 M glycine concentration, original solution pH 7.5, liquid/solid ratio of 7/1, for 3 hours contact time and 2% peroxide at room temperature (25°C), leaching efficiency of copper and uranium achieve 98.2% and 85% respectively. The leached metals value copper and uranium had been recovered by precipitation processes, the former with sodium sulphide, whereas the later can be recovered from copper free solution after adjusting at pH 5 and precipitation with hydrogen peroxide.

3D printed microfluidic mixer for real-time monitoring of organic reactions by direct infusion mass spectrometry

3D printing is a technology that has revolutionized traditional rapid prototyping methods due to its ability to build microscale structures with customized geometries in a simple, fast, and low-cost way. In this sense, this article describes the development of a microfluidic mixing device to monitor chemical reactions by mass spectrometry (MS). Microfluidic mixers were designed containing 3D serpentine and Y-shaped microchannels, both with a pointed end for facilitating the spray formation. The devices were fabricated entirely by 3D printing with fusion deposition modeling (FDM) technology. As proof-of-concept, micromixers were evaluated through monitoring the Katritzky reaction by injecting simultaneously 2,4,6-triphenylpropyllium (TPP) and amino acid (glycine or alanine) solutions, each through a different reactor inlet. Reaction product was monitored online by MS at different flow rates. Mass spectra showed that the relative abundances of the products obtained with the device containing the 3D serpentine channel were three times greater than those obtained with the Y-channel device due to the turbulence generated by the barriers created inside microchannels. In addition, when compared to the conventional electrospray ionization mass spectrometry (ESI-MS) technique, the 3D serpentine mixer offered better performance measured in relation to the relative abundance values for the reaction products. These results as well as the instrumental simplicity indicate that 3D printed microfluidic mixer is a promising tool for monitoring organic reactions via MS.

Graphenoxide Cross-Linker Based Potentiometric Biosensor Design for Sarcosine Determination.

Sarcosine, also known as N-methyl glycine, is a natural amino acid that is an intermediate and by product in glycine synthesis and degradation. Recently found in many peptides, sarcosine has been researched as a newly accepted prostate cancer marker. The increased concentration of sarcosine in blood serum and the urine showed that malignancy of measured prostate cancer cells is active. In this article, we aimed to design a potentiometric biosensor for detection of sarcosine with a low detection limit, high selectivity, short response time, wide linear range, and satisfactory long-term stability. In this article, we developed a new Graphene oxide (GFOX) photosensitive cross-linker based potentiometric biosensor based on the AmiNoAcid (monomer) Decorated and Light Underpinning Conjugation Approach (ANADOLUCA) method. The functional groups determined using Raman, FT-IR, XPS analyzes, and surface characterization, the morphology of synthesized GFOX photosensitive cross-linker were determined by TEM and AFM studies. Then, the performance of the GFOX based potentiometric biosensor has been evaluated. When the usage of the developed GFOX doped potentiometric biosensor against sarcosine determination, it was found that 10-4 mM sarcosine was determined in 60 seconds in the solution. In addition, the detection limit of the GFOX doped potentiometric biosensor was found to be 9.45x10-7 mM, and the linear potentiometric biosensor was found to be in the concentration range of 10-1 to 10-5 mM. The selectivity studies of the developed potentiometric biosensor were investigated using glycine solutions, and it was determined that GFOX doped potentiometric biosensor was more selective against sarcosine. Besides this, a reusability test using 10-3 mM sarcosine solution showed that reproducible studies were performed without the loss of potential of designed potentiometric biosensor and no loss of sensitivity. After applying the framework, we get a new potentiometric biosensor for sarcosine determination. GFOX photosensitive cross-linker was used in designing potentiometric biosensors, and this increased the stability and efficiency of the biosensor. Therefore, the developed potentiometric biosensor for sarcosine determination could be easily used for the early diagnosis of prostate cancer.

Application of amino acids in the modification of polylactic acid nanofiber scaffolds

In this study, thermal-induced phase separation technology (TIPS) and ammonolysis method were used to prepare modified polylactic acid (PLLA) nanofiber scaffolds with higher hydrophilicity using serine (Ser), glycine (Gly), and lysine (Lys) solutions as ammonolysis agents to prepare modified PLLA nanofibers. The results showed that aminolysis reduced the molecular weight of PLLA, and the introduction of amino acids affected the scaffold morphology and provided a better condition to prepare nanofiber scaffolds. The water contact angle of the modified PLLA nanofiber scaffold prepared by amino acids was improved compared to the unmodified PLLA scaffold. The modified PLLA nanofiber scaffold prepared from Ser, Gly, Lys exhibited lower mechanical properties than the PLLA scaffold prepared from water, meeting the pressure resistance requirements of engineered cartilage tissue scaffolds.

Prospects of foliar treatments with glycine solution to increase the productivity of dill

Relevance. Dill is a popular food and medicinal crop (Anethum graveolens L.) of the Celery family (Apiaceae). Seeds of dill are included in the 14th edition of the State Pharmacopoeia of the Russian Federation. However, this crop is characterized by a relatively low yield, which reduces the efficiency of its production. The use of environmentally friendly growth-regulating compounds can significantly increase the yield and improve its quality. As a growth-regulating, foliar treatment with a solution of the amino acid glycine was tested. The amino acid glycine is environmentally friendly and does not pose a danger to humans and animals. The aim of the work was to increase the productivity of garden dill using foliar treatments with glycine amino acid.Materials and methods. Dill varieties Gribovsky and Symphony were chosen as objects to study the effect of the foliar treatments with glycine. Sowing of seeds was carried out at an early date, which for the conditions of the Lipetsk region corresponds to the first decade of April, with a SZT-3.6 seeder with 15 cm row spacing. The seeding rate was 15 kg/ha, the seeding depth was 1-2 cm. were Treatment with glycine solution was achieved in plants rosette phase. The concentration of glycine was 25, 50 and 100 mg / l. The control plants were sprayed with distilled water. The crop was cut during the period of brown seeds on the central umbrella. The content of essential oil was determined by the 14th edition of the State Pharmacopoeia of the Russian Federation (method 1). The content of the main components was determined by gas chromatography.Results. As a result of the research, a positive effect of foliar treatments with glycine on both yield and the content of essential oil in the raw material of dill varieties Gribovsky and Symphony was revealed. As a result of treatments, regardless of concentration, the seeds yield and the yield of essential oil per unit area increased. The increase in the mass of 1000 pieces of fruits was not unambiguous. Based on the results obtained, the effective concentration of amino acid glycine is determined not only by the characteristics of the variety, but also by weather conditions, when, depending on the conditions during the processing period and prior to harvesting, different aspects of the drug's action appear. According to the results of observations for 2 years and an assessment by the sum of the indicators, the optimal concentration of glycine in most cases was 100 mg / l, at the same time, for the Symphony variety for two years, two-foliar treatment with low concentrations of glycine (10 mg / l rosette + 10 mg / l budding).