Solubility Of NaCl Research Articles

Rigorous analysis of non-ideal solubility of sodium and copper chlorides in water vapor using Pitzer-Pabalan model

Gaseous mixtures of water vapor and neutral molecules of salt (e.g., NaCl, CuCl etc.) can be highly non-ideal due to a strong attractive interaction between salt and water molecules. In particular, this can result in high solubility of salts in water vapor and a strong dependence of solubility on vapor pressure. The analysis of salt solubility in water vapor can be done using the Pitzer-Pabalan model, which is based on the thermodynamic theory of imperfect gases. The original Pitzer-Pabalan work demonstrated that one can reproduce experimental data for NaCl solubility in vapor. No analysis was performed on the reliability of their original fits, which we believe has contributed to the lack of applications of the Pitzer-Pabalan model despite the apparent success of the original paper. In this work, we report our recent progress in developing a rigorous fitting procedure to parameterize the Pitzer-Pabalan model using experimental data. Specifically, we performed fitting of the experimental results obtained elsewhere for NaCl and CuCl. We investigate the degree of underfitting/overfitting and the sensitivity of the fitting quality to variations in the resulting fitting parameters. The results, as represented by the thermodynamic parameters describing the energetics of formation of salt-bearing water clusters, were successfully benchmarked against Gaussian 16 ab initio quantum chemistry calculations. The resulting rigorous fitting procedure presented here can now be applied to other systems.

Salting-out precipitation of NaCl, KCl and NH4Cl in mixtures of water and methanol described by the modified Pitzer model

Experimental data and modelling of electrolyte solutions are important in different fields. Separation and purification of such materials depend on knowledge of solid-liquid equilibrium as well as the mathematical models allow the development of solution theories and process simulators. Therefore, the current work presents the study of NaCl, KCl and NH4Cl solubility in binary liquid solutions formed by water and methanol at temperatures ranging from 288.15 K to 328.15 K. Solubility decreases with increasing methanol concentration and increases with increasing temperature, with the exception of the NaCl, where the temperature has a minimum effect on its solubility. The modified Pitzer model was applied to describe the solid-liquid equilibrium and its successful implementation also described the salting-out precipitation by the addition of an anti-solvent.

Lennard-Jones Parameters Determined to Reproduce the Solubility of NaCl and KCl in SPC/E, TIP3P, and TIP4P/2005 Water.

Most classical nonpolarizable ion potential models underestimate the solubility values of NaCl and KCl in water significantly. We determine Lennard-Jones parameters of Na+, K+, and Cl- that reproduce the solubility as well as the hydration free energy in dilute aqueous solutions for three water potential models, SPC/E, TIP3P, and TIP4P/2005. The ion-oxygen distance in the solution and the cation-anion distance in salt are also considered in the parametrization. In addition to the target properties, the hydration enthalpy, hydration entropy, self-diffusion coefficient, coordination number, lattice energy, enthalpy of solution, density, viscosity, and number of contact ion pairs are calculated for comparison with 17 frequently used or recently developed ion potential models. The overall performance of each ion model is represented by a global score using a scheme that was originally developed for comparison of water potential models. The global score is better for our models than for the other 17 models not only because of the quite good prediction for the solubility but also because of the relatively small deviation from the experimental value for many of the other properties.

Determination of NaCl and Na2SO4 Equilibrium Solubility in Cyclohexanol and Cyclohexanone Aqueous Solutions at 323.15 K

The equilibrium solubility and physical properties (nD, η, and ρ) of NaCl and Na2SO4 in cyclohexanol and cyclohexanone aqueous solutions at 323.15 K were determined by an isothermal solution saturation method. According to the experimental data, the phase diagrams and diagrams of physical properties vs composition were plotted. The system of NaCl and Na2SO4 in cyclohexanol aqueous solution at 323.15 K can be divided into one invariant point, two univariant curves, and three crystallization regions. The physical properties of this system changed regularly with the change of the solubility of Na2SO4. The solubility of Na2SO4 and NaCl significantly reduced due to the presence of cyclohexanol in water. With the increase of the cyclohexanol content in aqueous solution in the system, the crystallization region of Na2SO4 increased obviously. The system of NaCl and Na2SO4 in cyclohexanone aqueous solution consisted of one invariant point, two univariant curves, and two crystallization regions corresponding to NaC...

Common-Ion Effect Triggered Highly Sustained Seawater Electrolysis with Additional NaCl Production.

Developing efficient seawater-electrolysis system for mass production of hydrogen is highly desirable due to the abundance of seawater. However, continuous electrolysis with seawater feeding boosts the concentration of sodium chloride in the electrolyzer, leading to severe electrode corrosion and chlorine evolution. Herein, the common-ion effect was utilized into the electrolyzer to depress the solubility of NaCl. Specifically, utilization of 6 M NaOH halved the solubility of NaCl in the electrolyte, affording efficient, durable, and sustained seawater electrolysis in NaCl-saturated electrolytes with triple production of H2, O2, and crystalline NaCl. Ternary NiCoFe phosphide was employed as a bifunctional anode and cathode in simulative and Ca/Mg-free seawater-electrolysis systems, which could stably work under 500 mA/cm2 for over 100 h. We attribute the high stability to the increased Na+ concentration, which reduces the concentration of dissolved Cl− in the electrolyte according to the common-ion effect, resulting in crystallization of NaCl, eliminated anode corrosion, and chlorine oxidation during continuous supplementation of Ca/Mg-free seawater to the electrolysis system.

Multifunctional thin-film nanocomposite membranes comprising covalent organic nanosheets with high crystallinity for efficient reverse osmosis desalination

Covalent Organic Frameworks (COFs) are of significant interest as promising crystalline building blocks for molecular separation due to their abundance of permanent, well-defined and size-selective micro-channels. However, thus far, the implementation of COFs-based membranes is limited by their poor scalability and impossibility of bridging the gap from molecular to ion separation. Herein, a novel thin-film nanocomposite (TFN) membrane comprising regular COFs nanosheets (CONs) with high crystallinity able to achieve an excellent H2O/NaCl selectivity is presented, accompanied with simultaneously over three times improvement on water permeability. The effectiveness of CONs cross-linked into polyamide matrix on hindering NaCl solubility and diffusivity is confirmed from both solution-diffusion mechanism and nanochannel-confined transport mechanism. Thanks to the protection of CONs with secondary amide linkages and strong steric hindrance from ortho- and meta-positioned methyl groups, the TFN membranes yield outstanding chlorine resistance of 18000 ppm h via inhibition of N-chlorination and ring-chlorination reaction. In addition, CONs incorporation also endows the TFN membranes with excellent anti-bacterial efficiency up to 99.8%. Our CONs-based membranes pave a new way towards the multifunctional composite membrane materials for highly efficient clean energy and environmental sustainability.

Application of progressive freezing on forward osmosis draw solute recovery.

Progressive freezing is a solvent purification technology with low energy requirements and high concentration efficiency. Although these advantages make it a promising technology, the technique has never been explored for draw solution recovery for forward osmosis (FO). Hence, in this study, the progressive freezing process was used to concentrate three common diluted draw solutions: NaCl, MgCl2, and EDTA-2Na with different ice front speeds, stirring rates, and initial draw solution concentrations. Effective partition and intrinsic partition constants were also evaluated. The results reveal that the freezing process can achieve a draw solution recovery rate of 99.73%, 99.06%, and 98.65% with NaCl, MgCl2, and EDTA-2Na, respectively, using an ice front speed of 0.5 cm/h, a stirring rate of 2.62 m/s, and 30% of percentage of ice phase. Higher concentration efficiency for NaCl and MgCl2 was achieved due to the high solubility of NaCl and MgCl2 increased solute diffusion into the liquid phase solutions. The concentration factors for all three draw solutions exceeded 1.9, indicating that the draw solutes could be reused for the FO process. In addition, the two mass transfer coefficients depended on the ice front speed and the stirring rates were also obtained for scaling up the experiment in the future.

Influence of multiphasic systems on salt(s) solubility in supercritical water: the case of NaCl and NaCl-Na2SO4

Supercritical water oxidation processes (SCWO) have been developed as an alternative technology to treat toxic and/or complex chemical wastes with a very good efficiency. However, one main limitation of the SCWO process comes from the precipitation of inorganic compounds. When dealing with supercritical water conditions (T ≥ 374 °C, p ≥ 22.1 MPa), the polarity of water drops and inorganics, such as salts, are no longer soluble. This precipitation phenomenon results in a solid salt deposition in the reactor, which can lead to clogging and interruption of the continuous process. Considering a specific salt, beside its intrinsic solubility in supercritical water, the presence of other salts or other compounds in the media can modify its precipitation behaviour. With the use of a specific experimental set-up, we propose in the present work to study the solubility of NaCl (type I salt) in supercritical water, and the influence of its phase diagram on its precipitation behaviour as well as on the solubility of a second salt, Na2SO4 (type II salt). The complex and dynamic aspect of NaCl precipitation has been studied through the use of a continuous solubility measurement set-up, revealing unexpected results.

Physicochemical properties of caprine and commercial bovine whey protein concentrate

Whey protein from caprine milk, a by-product of cheese manufacturing, was recovered by ultrafiltration technology and dried by lyophilization. A caprine whey protein concentrate (WPCc) with 64.60% of protein content was prepared. The physicochemical properties of WPCc samples under different solutions (water or 0.1 M NaCl aqueous solution) and thermal conditions (25 °C and treatment at 90 °C for 30 min) were evaluated and compared with commercial bovine whey protein concentrate (WPCb). The chemical composition and the amino acid profiles were also determined. Both WPCc and WPCb showed high solubility in 0.1 M NaCl (almost 100%) and low solubility (38%) under heat treatment and at pH 5 (close to the isoelectric point). WPCc had a greater content of free sulfhydryl groups and higher positive and negative zeta potentials at extreme pH values than WPCb; however, the surface hydrophobicity of WPCc was lower. With respect to bovine whey protein concentrate, the caprine whey proteins presented higher amounts of basic amino acid and also of isoleucine, methionine, glycine and histidine. Results obtained in this work indicated that the caprine whey protein concentrate presents good and similar physicochemical properties to those observed for bovine whey protein concentrate and that it could be used for the same food applications.

Measurements and Modeling of the Phase Equilibria in AlCl3 + NaCl + CaCl2 + H2O and AlCl3 + CaCl2 + NH4Cl + H2O Systems

Solid–liquid phase equilibrium for chloride salt systems plays a vital role in the utilization of liquid wastes generated from soda ash production by the Solvay process. The equilibrium data for ternary systems AlCl3–NaCl–H2O, AlCl3–NH4Cl–H2O, and CaCl2–NH4Cl–H2O from 283 to 353 K were determined by a dynamic method. A chemical model for these systems was developed with the mixed-solvent electrolyte model parameterization with the average absolute relative deviation less than 5%. The new model is capable of calculating solubilities of NaCl and NH4Cl in the AlCl3–CaCl2–H2O system, and the average absolute relative deviation of predicted points is less than 6%. The experimental and calculated phase equilibria have been used in developing a recovery method for NaCl and CaCl2 in the liquid wastes from the Solvay process and the subsequent utilization of CaCl2.

Selective Removal of Sodium from Low-Rank Xinjiang Coal upon Multistage Countercurrent Water Washing: Experimental Investigation and Kinetics Modeling

Prior washing of coal is an essential step for the minimization of ash-related slagging and fouling inside a coal-fired boiler. With regard to the coal washing process, the recyclability of the washing reagent, usually water, is critical from both cost-effective and efficiency perspectives. This paper addresses the washing kinetics of water-soluble Na+ from two different low-rank Xinjiang coals using both fresh and used/recycled water to alleviate the ash-related fouling in low-rank coal-fired boilers. Apart from once-through fresh water washing, washing using recycled water via both multicycle single-stage and three-stage countercurrent processes was studied in detail to investigate the recyclability of water. Additionally, a modified shrinking core model (SCM) was developed to reveal the Na+ removal mechanism under all washing conditions. Our experimental results showed that the Na+ removal extent decreased with the recycling of used water due to an increase in the Na+ concentration in the recycled water and/or a decrease in the Na+ content in the washed coal. The saturation point of Na+ in the used water, beyond which the water can no longer remove Na+, is far below the solubility of NaCl in water. The modeling approach further confirmed that the overall rate for the removal of water-soluble Na+ is dominated by the intraparticle diffusion within the coal matrix. The effective diffusion coefficient of Na+ was within the range of 0.28 × 10–6 to 3.75 × 10–6 cm2/s, which agrees with reported values in the literature. Additionally, a novel iterative calculation method integrating the modified SCM into the three-stage countercurrent washing process has been proposed to predict the Na+ removal at each stage for each cycle. The results show that the water can be recycled a maximum of 15 times in the three-stage countercurrent process.

Solid-Liquid Phase Equilibria of the Ternary System (NaCl + CH3OH + H2O) at 298.15, 308.15, 318.15 K, and 0.1 MPa

The phase equilibrium of the ternary system (NaCl + CH3OH + H2O) at 298.15, 308.15, 318.15 K, and 0.1 MPa has been investigated by the isothermal dissolution equilibrium method. Solubilities and physicochemical properties including refractive index (nD) and density (ρ) in the ternary system were determined experimentally. According to the experimental data, the phase diagrams and diagrams of physicochemical properties versus sodium chloride concentration in the solvents at 298.15, 308.15, and 318.15 K were plotted, respectively. The experimental results showed that the system did not cause stratification and the equilibrium solid phase was anhydrous sodium chloride. Neither double salt nor solid solution was found at the three temperatures. The physicochemical properties of the ternary system change regularly with the increase of sodium chloride concentration in the solution, and the solvation effect of CH3OH on NaCl was significant. Moreover, the calculated values of NaCl solubility data based on the CNIBS/R-K equations agreed well with the experimental results, and the thermodynamic functions in the dissolution process of NaCl in the CH3OH-H2O binary system were also calculated for further investigation of NaCl dissolution process.

Key Role of Lanthanum Oxychloride: Promotional Effects of Lanthanum in NiLaOy /NaCl for Hydrogen Production from Ethyl Acetate and Water.

The hydrogen economy is accelerating technological evolutions toward highly efficient hydrogen production. In this work, the catalytic performance of NiO/NaCl for hydrogen production via autothermal reforming of ethyl acetate and water is further improved through lanthanum modification, and the resulted 3%-NiLaOy /NaCl catalyst achieves as high as 93% H2 selectivity and long-term stability at 600 °C. The promoting effect is caused by the strong interactions between lanthanum and NiO/NaCl, by which LaNiO3 and a novel LaOCl phase are formed. The key role of LaOCl in promoting low-temperature hydrogen production is highlighted, while effects of LaNiO3 are well known. The LaOCl (010) facet possesses high adsorption capacity toward co-chemisorbing ethyl acetate and water. LaOCl strongly interacts with ethyl acetate and H2 O in the form of hydrogen bonding and coordination effect. The interactions induce tensions inside ethyl acetate and H2 O, activate the molecules, and hence decrease the energy barrier for reaction. In situ Fourier transform infrared spectroscopy (FTIR) reveals that LaOCl along with NaCl enhances the adsorption ability of NiO/NaCl. Moreover, LaOCl improves the dispersion of Ni species in NiO-LaNiO3 -LaOCl nanosheets, which possess abundant active sites. The effects together promote hydrogen evolution. Furthermore, the NiLaOy /NaCl catalyst can be easily reborn after deactivation due to the water solubility of NaCl.

NaCl-saturated brines are thermodynamically moderate, rather than extreme, microbial habitats.

NaCl-saturated brines such as saltern crystalliser ponds, inland salt lakes, deep-sea brines and liquids-of-deliquescence on halite are commonly regarded as a paradigm for the limit of life on Earth. There are, however, other habitats that are thermodynamically more extreme. Typically, NaCl-saturated environments contain all domains of life and perform complete biogeochemical cycling. Despite their reduced water activity, ∼0.755 at 5 M NaCl, some halophiles belonging to the Archaea and Bacteria exhibit optimum growth/metabolism in these brines. Furthermore, the recognised water-activity limit for microbial function, ∼0.585 for some strains of fungi, lies far below 0.755. Other biophysical constraints on the microbial biosphere (temperatures of >121°C; pH > 12; and high chaotropicity; e.g. ethanol at >18.9% w/v (24% v/v) and MgCl2 at >3.03 M) can prevent any cellular metabolism or ecosystem function. By contrast, NaCl-saturated environments contain biomass-dense, metabolically diverse, highly active and complex microbial ecosystems; and this underscores their moderate character. Here, we survey the evidence that NaCl-saturated brines are biologically permissive, fertile habitats that are thermodynamically mid-range rather than extreme. Indeed, were NaCl sufficiently soluble, some halophiles might grow at concentrations of up to 8M. It may be that the finite solubility of NaCl has stabilised the genetic composition of halophile populations and limited the action of natural selection in driving halophile evolution towards greater xerophilicity. Further implications are considered for the origin(s) of life and other aspects of astrobiology.

In situ high-pressure measurement of crystal solubility by using neutron diffraction.

Crystal solubility is one of the most important thermo-physical properties and plays a key role in industrial applications, fundamental science, and geoscientific research. However, high-pressure in situ measurements of crystal solubility remain very challenging. Here, we present a method involving high-pressure neutron diffraction for making high-precision in situ measurements of crystal solubility as a function of pressure over a wide range of pressures. For these experiments, we designed a piston-cylinder cell with a large chamber volume for high-pressure neutron diffraction. The solution pressures are continuously monitored in situ based on the equation of state of the sample crystal. The solubility at a high pressure can be obtained by applying a Rietveld quantitative multiphase analysis. To evaluate the proposed method, we measured the high-pressure solubility of NaCl in water up to 610 MPa. At a low pressure, the results are consistent with the previous results measured ex situ. At a higher pressure, more reliable data could be provided by using an in situ high-pressure neutron diffraction method.

Chitosan/graphene oxide mixed matrix membrane with enhanced water permeability for high-salinity water desalination by pervaporation

Pervaporation is a promising technology for water desalination. In this work, graphene oxide (GO) was incorporated into chitosan (CS) to fabricate mixed matrix membranes (MMMs) to explore the enhancement of water permeability for high-salinity water desalination and to understand the transport mechanism in the MMMs. The effect of GO content on the morphology, wettability and desalination performance of the membranes as well as the thermodynamic and kinetic behavior of water and salt permeation in the membranes were investigated. The MMMs have rougher and more hydrophilic surface, dense structure and improved mechanical stability owing to the good chemical compatibility of GO with CS matrix. The apparent activation energy results indicate the advantage of the MMMs in desalinating high-salinity water. The enhanced permeate flux of 30.0 kg/m2·h was obtained in desalinating 5 wt% aqueous NaCl solution at 81 °C with 1 wt% GO content and 99.99% of salt rejection was achieved. The solubility and diffusivity of H2O and NaCl in the MMMs demonstrate a trade-off effect on the water permeability and water/salt selectivity with increasing of GO content. The NaCl diffusion coefficient in the membranes was lower than that of H2O by two orders of magnitude, contributing to the high selectivity of the membrane.

Hydrodechlorination of chlorophenols over Pd catalysts supported on zeolite Y, MCM-41 and graphene

Hydrodechlorination (HDC) reaction of chlorophenols was carried out using Pd catalysts supported over zeolite Y, MCM-41 or graphene. Pd-MCM-41 and Pd-Y zeolite were prepared by impregnation and ion-exchange method, respectively. Pd-graphene (Pd-G) was prepared by hydrazine hydrate reduction of palladium ion dispersed on graphene oxide. The catalysts were characterized by several analytical tools such as X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and energy-dispersive X-ray spectroscopy (EDS). These catalysts were subjected to HDC reaction of chlorophenols, such as 4-chlorophenol (4-CP), 2,4-dichlorophenol (2,4-DCP), 2,6-dichlorophenol (2,6-DCP) and 3,4-dichlorophenol (3,4-DCP). The reaction rate of HDC of chlorophenols catalyzed by Pd catalysts with various solid bases, such as KF/Al2O3 (alumina), sodium acetate (NaOAc) and K2CO3 was compared. First, Pd-MCM-41 and Pd-Y catalysts were compared. 2,4- and 3,4-DCPs were completely decomposed within 6 h, in the case of Pd-MCM-41 with NaOAc. Using Pd-Y instead of Pd-MCM-41 with NaOAc, much faster decomposition was observed. Faster decomposition of 4-CP and DCPs was observed with NaOAc base than K2CO3 or KF/Al2O3 under the same condition. In the case of Pd-Y with KF/Al2O3, slower decomposition of 4-CP and DCPs was observed. These base effects were interpreted using the solubility of NaCl and KCl in alcohol and the basic sites of KF/Al2O3. Because the solubility of NaCl is known to be larger than KCl solubility in alcohol, byproduct NaCl could be easily dissolved and ionized in solvents. For Pd-Y with KF/Al2O3, the small pore size of Y zeolite can interfere with the diffusion of HCl to KF/Al2O3 basic site. Second, three catalysts, including Pd-graphene, were compared. 2,4-DCP was decomposed within 2 h using Pd-G with either K2CO3, NaOAc or KF/Al2O3. Pd-G catalyst showed the highest catalytic activity among Pd-G, Pd-MCM-41 and Pd-Y catalysts. The high activity and stability of the Pd-G could be attributed to the strong metal–support interaction with an electron-deficient site and a critical Pd particle size (ca. 3.5 nm) of Pd-G nanocatalyst with a stronger resistance to the deactivation and good affinity toward aromatic organic molecules, especially phenols. The progress of HDC reaction was monitored by gas chromatography with flame ionization detection (GC/FID), and a feasible degradation process could be explained by analyzing the degradation products such as phenol, cyclohexanone and cyclohexanol from resulting GC chromatograms. The effect of reaction temperature on HDC in Pd-G catalyst was also discussed. In conclusion, Pd-G is an efficient catalyst for decomposition of chlorophenols and can be applied to remediation of chlorophenol-contaminated water under mild conditions.

Investigating the Potential Use of Ionic Liquids in Pre-Treatment Application for Water Desalination

The world has been noticing a quickening advancement over the last decades in terms of irrigated agriculture, social, industrial, and economical perspectives; followed by a huge increment in the water demand. Therefore, desalination is used all over the world to reduce worldwide water shortage; however, the traditional techniques lead to fossil fuel depletion and global warming. Therefore, scientists are investigating new green and environment-friendly methods to be used by the desalination plants to reduce CO2 emissions and save the natural resources. In this study, the feasibility of using ionic liquids (ILs) as potential means for pre-treatment of seawater desalination was examined. The main aim of this work was to examine the ability of ILs in extracting salts from saline water. As a first step, the solubility of NaCl, MgCl2, and CaCl2 in different ILs at different temperatures were analyzed. The solubility of the salts in ILs increased in most cases with temperature increments; however, the presence of emulsion was seen in a few cases. The highest measured concentration of NaCl was 6,639 ppm at 60 °C in 1,3-Dimethylimidazolium dimethyl phosphate.

Modeling solubility and acid-base properties of some polar side chain amino acids in NaCl and (CH3)4NCl aqueous solutions at different ionic strengths and temperatures

The aim of the paper is to perform a critical analysis of the thermodynamic properties of five L-α-amino acids, namely arginine, aspartic acid, glutamic acid, glutamine and histidine. New potentiometric measurements to determine protonation constants and solubility (not for arginine) in NaCl and (CH3)4NCl aqueous solutions are reported, in order to investigate the medium effect. A preliminary analysis of the state of art evidenced the considerable amount of data in the ionic strength range 0 < I/mol kg−1 ≤ 0.1 and a lack of data (especially for arginine and glutamine) above 0.1 mol kg−1. For this reason, this paper deals with an analysis of both the literature and the new experimental data, assigning a weight to each datum as a function of its reliability. The ionic strength dependence of the protonation constants was interpreted using the EDH (Extended Debye-Hückel), the SIT (Specific ion Interaction Theory) and the Pitzer approaches. Simultaneous analysis of solubility data and protonation constants allowed us to obtain the Setschenow and the activity coefficients of all the species involved in the equilibria. The differences between the two media were also interpreted considering the formation of weak complexes between the ions of the supporting electrolytes and the ligands according to the complex formation model.Finally, recommended, tentative or provisional data for protonation constants and protonation enthalpy changes of the five amino acids at different temperatures and ionic strengths are provided.

Solid–Liquid Equilibria for the Glycine–Alcohol–NaCl–H2O System

An investigation of the solubility of glycine–alcohol (ethanol/1-propanol)–NaCl–H2O system was carried out by dynamic method over the temperature range from 283.15 to 333.15 K. The studied systems were glycine–alcohol (ethanol/1-propanol)–H2O, glycine–ethanol–NaCl (0.5, 1.0, 2.0 mol·kg–1 water)–H2O, glycine–1-propanol–NaCl (0.5 mol·kg–1 water)–H2O, and NaCl–alcohol (ethanol/1-propanol)–glycine (0.25 mol·kg–1 water )–H2O. The solubilities of glycine and NaCl were found to increase with increasing temperature and decrease with increasing concentration of alcohols. A chemical model was successfully developed based on the mixed solvent electrolyte (MSE) model by regressing experimental and literature solubilities data of glycine in the glycine–ethanol–NaCl–H2O and glycine–1-propanol–H2O systems. New sets of middle range and UNIQUAC interaction parameters were obtained. The average absolute deviation between regressed and experimental values was found to be less than 7%.