A database of alkaline and alkaline earth chloride solubilities in water at various temperatures was created using data from more than 670 publications over about the last two centuries. Statistical critical evaluations of the created database were produced since there were enough independent data sources to justify such evaluations. The reliable experimental data were adequately described by polynomial expressions over various temperature ranges. Using the Pitzer approach for ionic activity and osmotic coefficients, the thermodynamic solubility products for the discussed minerals have been calculated at various temperature intervals and also represented by polynomial expressions. The solubility products calculated in the current study yield excellent agreement between the predicted and experimental mineral solubility values in natural waters over a wide range of temperature and ionic solution matrices.