Solitary Lung Tumors Research Articles

Solitary Lung Tumors and Their Spontaneous Metastasis in Athymic Nude Mice Orthotopically Implanted with Human Non-Small Cell Lung Cancer

We examined the tumorigenic and metastatic potentials of three human non-small cell lung cancer (NSCLC) cell lines. PC-14, A549 or Lu-99 cell lines suspended in Matrigel-containing phosphate-buffered saline were orthotopically implanted into the lungs of nude mice. The formation of a solitary tumor nodule in the lung was observed after the implantation of all cell lines. Intrapulmonary implantation of PC-14 or Lu-99 cells resulted in spontaneous distant metastases. In contrast, A549 cells caused multiple intrapulmonary metastases to the right and left lobes of the lung without producing visible lymphatic metastasis. We also investigated the expression of matrix metal loproteinases (MMPs), urokinase-type plasminogen activator (u-PA), u-PA receptor (u-PAR) and c-MET in these cell lines in vitro and in vivo. Reverse transcription polymerase chain reaction (RT-PCR) analysis showed that the expression of MMP-2 and membrane-type 1 MMP (MT1-MMP) was elevated in PC-14 as compared with the other two cell lines. In contrast, stronger expression of c-METwas observed in A549 than in PC-14 or Lu-99. These results indicate that differential patterns of metastasis of lung cancer might be associated with differential expression of metastasis-associated molecules. Our orthotopic implantation models display clinical features resembling those of NSCLC, may provide a useful basis for lung cancer research.

2257 Initial clinical findings of 3-D conformal radiotherapy for solitary lung tumor using a stereotactic body frame. Part 2. Treatment planning and clinical outcome

2257 Initial clinical findings of 3-D conformal radiotherapy for solitary lung tumor using a stereotactic body frame. Part 2. Treatment planning and clinical outcome

2256 Initial clinical findings of 3-D conformal radiotherapy for solitary lung tumors using a stereotactic body frame. Part 1. Setup accuracy

2256 Initial clinical findings of 3-D conformal radiotherapy for solitary lung tumors using a stereotactic body frame. Part 1. Setup accuracy

Prognosis factors for survival in cats after removal of a primary lung tumor: 21 cases (1979-1994).

To identify possible prognostic factors for survival time in cats with a primary lung tumor after surgical excision. Retrospective clinical study. 21 cats with histologically confirmed primary lung tumors removed surgically. Medical records for cats treated between 1979 and 1994 at 14 participating veterinary referral hospitals were reviewed. After surgical resection and recovery, 18 cats died from metastatic disease with a median survival time of 115 days (range, 13 to 1,526 days). Three cats were lost to follow-up at 119 days, 251 days, and 410 days after the surgical procedure. Contingency table analysis to determine if an association existed between clinical findings (breed, age, gender, body weight, clinical signs, duration of clinical signs, and radiographic findings) or histological features and survival time was performed. Only histological morphology of the primary lung tumor showed a significant association with survival time. Twelve cats with moderately differentiated tumors had a significantly longer survival time (median, 698 days; range, 19 to 1,526 days) than the nine cats with poorly differentiated tumors (median, 75 days; range, 13 to 634 days). Surgical resection of a solitary primary lung tumor in cats is indicated. A poor prognosis for long-term survival is warranted for those cats having a poorly differentiated primary lung tumor.

Video-assisted thoracoscopic wedge resection of solitary pulmonary metastasis from hepatocellular carcinoma

We report a metastatic pulmonary tumor resected by video-assisted thoracoscopic surgery. A 63-year-old female was found to have four nodules of hepatocellular carcinoma (HCC) in January 1991; after non-surgical treatment, the tumors had become necrotic. In June 1992, a new HCC nodule was found. After infusion chemotherapy, it became necrotic. In September 1993, a solitary lung tumor, 2.4 cm in diameter, appeared at the periphery of the right lung. Because the tumor was considered to be a metastatic HCC rather than a primary lung cancer, it was removed by thoracoscopic wedge resection. Although whether metastasectomy contributes to prolongation of survival is still controversial, thoracoscopic pulmonary resection may be indicated for solitary peripheral metastasis, if the primary HCC is well controlled by multidisciplinary treatment.

Localized bronchiectasis simulating pulmonary neoplasms.

Article1 July 1955LOCALIZED BRONCHIECTASIS SIMULATING PULMONARY NEOPLASMSBENJAMIN SCHWARTZ, M.D., HARRY L. KATZ, M.D.BENJAMIN SCHWARTZ, M.D.Search for more papers by this author, HARRY L. KATZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-43-1-45 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWith progressively wider utilization of routine chest roentgenograms, an increasing number of intrathoracic lesions is being discovered in asymptomatic persons. Once these abnormal pulmonary shadows are visualized radiologically it becomes the responsibility of the clinician to evaluate the nature of the pulmonary lesion in order that the proper therapy may be promptly instituted. Among the varied lesions that may be revealed by routine chest radiography, the isolated and circumscribed pulmonary densities often present elusive and challenging problems in diagnosis. The diagnostic studies required in such cases include the following:1. A complete medical history. This should include a detailed review...Bibliography1. HoodGoodClagettMcDonald RTCAOTJR: Solitary circumscribed lesions of the lung, J. A. M. A. 152: 1185, 1953. CrossrefMedlineGoogle Scholar2. HodgsonMcDonald CHJR: The diagnosis and management of solitary circumscribed lesions of the lungs, Dis. of Chest 24: 289, 1953. CrossrefMedlineGoogle Scholar3. StoreyGrantRothman CFRABF: Coin lesions of the lung, Surg., Gynec. and Obst. 97: 95, 1953. MedlineGoogle Scholar4. ClarkTempelAllen DCWKD: Diagnosis of pulmonary lesions discovered by mass roentgenographic survey, J. A. M. A. 143: 943, 1950. CrossrefMedlineGoogle Scholar5. OverholtWilson RHNJ: Silent and masquerading intrathoracic lesions. The importance of proper identification of lesions discovered during x-ray surveys, New England J. Med. 234: 169, 1946. CrossrefMedlineGoogle Scholar6. HuizingaHolland EG: Bronchography in bronchial cancer and collateral ventilation, J. Thoracic Surg. 23: 445, 1952. CrossrefGoogle Scholar7. ChapmanWiggins JJA: Circumscribed and isolated bronchiectasis, Ann. Int. Med. 14: 2047, 1941. LinkGoogle Scholar8. Hall AS: Two examples of localized bronchiectasis, Tubercle 19: 278, 1938. CrossrefGoogle Scholar9. Shaw RR: Mucoid impaction of the bronchi, J. Thoracic Surg. 22: 149, 1951. CrossrefGoogle Scholar10. RamsayByron BHFX: Mucocele, congenital bronchiectasis and bronchiogenic cyst, J. Thoracic Surg. 26: 21, 1953. CrossrefGoogle Scholar11. MayerRappaport EI: Developmental origin of cystic, bronchiectatic and emphysematous changes in the lungs, Dis. of Chest 21: 146, 1952. CrossrefMedlineGoogle Scholar12. HellerHouseholderBenshoff ELJHAM: Bronchogenic cysts, Am. J. Clin. Path. 23: 121, 1953. CrossrefGoogle Scholar13. MillerGraubPashuck RFMET: Bronchogenic cysts, Am. J. Roentgenol. 70: 771, 1953. Google Scholar14. Ramsay BH: Mucocele of the lung due to congenital obstruction of a segmental bronchus, Dis. of Chest 24: 96, 1953. CrossrefMedlineGoogle Scholar15. GrowBradfordMahon JBMLHW: Exploratory thoracotomy in the management of intrathoracic disease, J. Thoracic Surg. 17: 480, 1948. CrossrefGoogle Scholar16. EfflerBladesMarks DBBE: The problem of solitary lung tumors, Surgery 24: 917, 1948. MedlineGoogle Scholar17. O'BrienTuttleFerkaney EJWMJE: The management of the pulmonary "coin" lesion, S. Clin. North America 28: 1313, 1948. CrossrefMedlineGoogle Scholar18. SharpKinsella DVTJ: The significance of the isolated pulmonary nodule, Minnesota Med. 33: 886, 1950. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication December 6, 1954.From the Pulmonary Clinic, Veterans Administration Regional Office, Brooklyn, N. Y., and the Chest Section, Veterans Administration Hospital, Brooklyn, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie BronchiektasienMucoid Impaction of the BronchiMUCOID IMPACTION OF THE BRONCHI*ALLEN E. GREER, M.D. 1 July 1955Volume 43, Issue 1Page: 45-60KeywordsBronchiectasisCoccidioidomycosisDiagnostic radiologyHistoplasmosisHospitalsLesionsLung and intrathoracic tumorsPneumonitisThoraxUpper respiratory tract infections ePublished: 1 December 2008 Issue Published: 1 July 1955 PDF downloadLoading ...

The diagnosis and management of asymptomatic isolated intrathoracic nodules

Article1 September 1952THE DIAGNOSIS AND MANAGEMENT OF ASYMPTOMATIC ISOLATED INTRATHORACIC NODULESSIDNEY E. WOLPAW, M.D., F.A.C.P.SIDNEY E. WOLPAW, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-3-489 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMass chest x-ray surveys, originally intended to detect early pulmonary tuberculosis, have also revealed that other intrathoracic lesions may be found with some degree of frequency in apparently healthy people. Particularly significant is the knowledge, now commonplace among chest physicians and thoracic surgeons, that in their early development many of these lesions are silent, the patient entirely unaware of their existence because symptoms are lacking. Even the most adept diagnostician is often unable to elicit their presence by the ordinary methods of physical examination. A varied assortment of symptomless intrathoracic conditions has been discovered in this manner. In this group...Bibliography1. FreedlanderWolpawMendelsohn SOSEHJ: Surgical experience with asymptomatic intrathoracic growths, Radiology 55: 700, 1950. CrossrefMedlineGoogle Scholar2. O'BrienTuttleFerkaney EJWMJE: The management of the pulmonary "coin" lesion, S. Clin. North America 28: 1313, 1948. CrossrefMedlineGoogle Scholar3. Effler DB: Solitary lung tumors, Am. Rev. Tuberc. 63: 252, 1951. MedlineGoogle Scholar4. AbelesEhrlich HD: Single, circumscribed, intrathoracic densities, New England J. Med. 244: 85, 1951. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland, Ohio*Presented at the Thirty-third Annual Session of the American College of Physicians, Cleveland, Ohio, April 22, 1952.From the Departments of Medicine, Cleveland City and Mt. Sinai Hospitals, and the Western Reserve University School of Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAn analysis of 155 solitary lung lesions illustrating the differential diagnosis of mixed tumours of the lungSolitary or “Coin” Lesions of the LungThe problem of circumscribed lung opacitiesEXFOLIATIVE CYTOLOGY IN SOLITARY PERIPHERAL LESIONS OF THE LUNGSThe solitary pulmonary noduleRundherde der LungePulmonary Metastasis from Occult Primary Sites Resembling Bronchogenic CarcinomaTHE SOLITARY PULMONARY NODULEThe Diagnostic Problem of Peripheral Pulmonary LesionsPulmonary “coin” lesionsBenign tumors of the bronchus and lungDiagnosis and Treatment of Solitary Circumscribed Nodules of the LungThe Differential Diagnosis of Chronic Pulmonary Disease 1 September 1952Volume 37, Issue 3Page: 489-505KeywordsHealth surveysHospital medicineLesionsSurgeonsThorax ePublished: 1 December 2008 Issue Published: 1 September 1952 PDF downloadLoading ...

The Pulmonary “Coin” Lesion

HomeRadiologyVol. 54, No. 1 PreviousNext EditorialThe Pulmonary “Coin” LesionPublished Online:Jan 1 1950https://doi.org/10.1148/54.1.116MoreSectionsPDF ToolsImage ViewerAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinked In AbstractThe widespread use of roentgenography of the chest as a detection agent in large series of normal or symptomless persons has inevitably raised problems both of diagnosis and management of the conditions thus disclosed. The solitary round, circumscribed, coin-like lesion is one that is frequently observed in the lungs of this asymptomatic group. With the multiplication of examinations we must expect the problem of its disposition to recur with increasing frequency. Shall we observe such lesions over varying periods of time or shall we advise surgical intervention for diagnostic and therapeutic considerations? This problem is of unusual interest to the radiologist, who will frequently be called upon for his opinion.Due to the marked improvement in the general technic of chest surgery, with the consequent lowering of the mortality, removal of these pulmonary lesions is now commonplace in many medical centers. O'Brien, Tuttle, and Ferkaney (3) reported their results in a series of 21 cases in which lobectomy or pneumonectomy was performed. In no instance was the diagnosis definitely established prior to operation. Bronchogenic carcinoma was found in 8 (38 per cent) and tuberculoma in an equal number, abscess in 2 (9.5 per cent), sarcoma, cyst, and chondroma in 1 case each (4.9 per cent). There were no surgical deaths in this series. Six of the patients were asymptomatic. Cough was the commonest symptom but was not severe. Hemoptysis occurred in 4 cases. Bronchoscope examination is often disappointing because these lesions occur in the lung periphery, but the cytologic study of bronchial washings gives promise of diagnostic aid.In the report of 24 cases of solitary lung tumors, Effler, Blades, and Marks (1) present the final results of operative removal. Each of the lesions in this series was discovered during a routine roentgen examination of the chest, and in every instance was asymptomatic. Each case was carefully studied preoperatively by a variety of diagnostic methods, without establishment of a definite diagnosis. It is of interest that all were considered benign, though the final analysis showed 4 malignant tumors. The series included, also, 7 cysts, 8 tuberculomas, 3 benign tumors, and 2 diaphragmatic hernias. No deaths were recorded. Effler and his associates make the point that surgical care is often asked for pulmonary lesions producing serious symptoms, but that many physicians hesitate to consider the asymptomatic patient as a candidate for operation. That 15 per cent of these symptomless tumors proved to be malignant is regarded as justification for the surgical exploration of every solitary lesion of the lung.Thoracotomy in 200 cases reported by Grow, Bradford, and Mahon (2) showed an over-all incidence of malignant tumors of 21.5 per cent. If only the intrapulmonary lesions are considered, the percentage rises to 25.6. This series was not confined to accidentally discovered asymptomatic lesions.Article HistoryPublished in print: Jan 1950 FiguresReferencesRelatedDetailsCited ByRadiopaedia.orgDanielBell, RupeshNamdev2014Handbuch der Medizinischen Radiologie / Encyclopedia of Medical RadiologyWernerSchulze1973 | , Vol. 9 / 4 / cDie Beurteilung von 273 Lungenrundherden unter besonderer Berücksichtigung der Konstanz des KrebswachstumsF.Stelzner, F.Stürtzbecher1959 | Langenbecks Archiv für Klinische Chirurgie, Vol. 292, No. 1THE SOLITARY PULMONARY NODULEEdgar W.Davis, J. WinthropPeabody, SolKatz1956 | Journal of Thoracic Surgery, Vol. 32, No. 6Pulmonary “coin” lesionsHarold GuyonTrimble1955 | The American Journal of Surgery, Vol. 89, No. 2Recommended Articles RSNA Education Exhibits RSNA Case Collection Vol. 54, No. 1 Metrics Altmetric Score PDF download