Objective: To estimate the prevalence of Hepatitis C virus (HCV) antibodies and the associated risk factors among municipal solid waste (MSW) collectors. Methods:A descriptive cross-sectional study was conducted upon MSW collectors (n=120) working in the Western Municipality of Mansoura city, Egypt. The collectors were interviewed to collect socio-demographic and occupational data, use of personal protective measures and different risk factors for exposure to infected blood. Blood specimens were collected and tested for HCV antibodies using ELISA technique. Results: A high prevalence (43.3%) of HCV antibodies was found among MSW collectors. The older age and the longer duration of employment of collectors were statistically significant demographic variables for HCV antibodies sero-positivity. Logistic regression analysis showed that the shorter duration of employment as waste collector was independently associated with lower likelihood of HCV antibodies seropositivity (OR = 0.3). Conclusion: MSW collectors are at increased risk for HCV infection. MSW collectors should be provided with the necessary protective measures, education and training programs, and routine medical check-up should be implemented and maintained, to keep them safe and secure.