Impact force remains the primary cause of foot injury and general discomfort with regard to footwear. The footwear industry traditionally relies on modified elastomers (including natural rubber) whose properties can be physically adjusted by varying the constituents in the rubber formulations. This work aims to investigate the effect of filler/plasticizer fractions on shock attenuation of natural rubber soles. The statistical response surface method (RSM) was used to optimize the loading of natural rubber, fillers (carbon black and china clay) and a plasticizer (paraffinic oil). A novel predictive equation addressing the effects of additives on the physical and mechanical properties of the shoe sole was successfully created using the RSM. Our results demonstrate how the concentrations of these components regulate final properties, such as impact force absorption and hardness, in the commercial manufacture of shoe soles. While a higher loading level of plasticizer promotes reductions in hardness and impact force, as well as energy dissipation, in these modified elastomers, these properties were improved by increasing the filler content.