Research on landscape glacial modelling provides particularly relevant information about the complex connection between climate change and relief evolution. Glacial valleys – the most distinctive landforms in alpine-type settings – were systematically mapped across the Fuegian Andes of Argentina, southernmost Patagonia, and quantitatively investigated in terms of the geoenvironmental agents that controlled their formation. A total of 646 troughs were identified and studied in four sub-areas with contrasting past glacial cover. Our observations demonstrate that longer valleys are also the deeper, less steep (in long profile), more sinuous and lower, and that maximum elevation was the main control of altitudinal range, mean and maximum slope, and minimum depth. Overall, it is considered that valley development was subject to conditioning by pre-glacial topography, geological structure and climatic forcings. Specifically, valley's spatial arrangement indicates that glaciers responsible for their erosion (possibly during the early Pleistocene) adjusted to a fluvial drainage network organized according to a marked structural control, mainly associated with Magallanes-Fagnano and Canal Beagle regional strike-slip systems. The predominance and higher degree of development of southern slope valleys reveal that north-south differential insolation effect was determinant in the Fuegian glaciers' balance during extensive time-lapses in glacial cycles, likely reflecting a scenario of relative aridity and comparatively clear skies. Morning-afternoon contrasts in solar radiation receipt and, specially, humid winds from the west (regional westerlies) would have also produced a moderate eastward bias in valley direction. In the western and central sectors, formerly covered by the Cordillera Darwin Icefield, the surface of Fagnano and Beagle outlet palaeolobes and other major collectors constituted a comparatively high base level for mountain glaciers' incision during full glacial conditions, leading to the creation of profuse, short hanging valleys. In the eastern domain, on the contrary, glaciers appear to have been essentially regulated by the topoclimatic factors, attaining greater dimensions and flowing down to lower altitudes in south- and southeast-facing slopes. Finally, in marginal, lower mountains (away from the main chain axis) ice is thought to have formed only under the most severe glacial episodes in the zone.