AbstractThe present study introduces a nature inspired improved liver cancer algorithm (ILCA) for solving the non‐convex engineering optimization issues. The traditional LCA (t‐LCA) inspires from the conduct of liver tumours and integrates biological ethics during the optimization procedure. However, t‐LCA facing stagnation issues and may trap into local optima. To avoid such issues and provide the optimal solution, there are some modifications are implemented into the internal structure of t‐LCA based on Weibull flight operator, mutation‐based approach, quasi‐opposite‐based learning and gorilla troops exploitation‐based mechanisms to enhance the overall strength of the algorithm to obtain the global solution. For validation of ILCA, the non‐parametric and the statistical analysis are performed using benchmark standard functions. Moreover, ILCA is applied to resolve the stochastic renewable‐based (wind turbines + PVs) optimal power flow problem using a modified RER‐based IEEE 57‐bus. The objective of this work is to obtain the minimum predicted power losses and enhance the predicted voltage stability. By incorporation of renewable resources into the modified IEEE57‐bus network can help the system to reduce the power losses from 5.6622 to 3.8142 MW, while the voltage stability is enhanced from 0.1700 to 0.1164 p.u.