Transient heat fluxes imposed on solid surfaces can significantly affect the heat transfer and pressure drop of flow boiling processes in diverse fields ranging from microprocessor electronics cooling to waste-heat recovery and large-scale direct steam generation in concentrated solar applications. A series of simulated transients were applied in this experimental study to investigate the saturated flow boiling of R-245fa in a horizontal pipe. The test section consisted of an 8.31 mm inner diameter, 800 mm long heated pipe. The imposed transient conditions involved spatially uniform but temporally varying heat fluxes imposed on the pipe. A baseline condition with a saturation temperature of 35°C, a heat flux of 7.5 kW/m2 and a mass flux of 200 kg/m2s was considered over a vapour quality range from 0.10 to 0.85. Motivated by direct steam generation application case studies and based on actual solar direct normal irradiation data, reductions with an amplitude of 75% of the baseline heat flux were imposed over a period of 30 s. The waveform types were step, triangular and sinusoidal pulses, and were applied in a controlled fashion. It was found that during the step perturbation, the heat transfer coefficient was approximately 30% lower than the steady state condition. The triangular and sinusoidal perturbations resulted in heat transfer coefficients that were 8% lower than that of the steady state. The pressure gradient through the test section was unaffected by the imposed perturbations.