In the traditional design method, structures are usually assumed as rigid base structures without considering soil-structure interaction (SSI). However, whether the effect of SSI on the seismic performance of structures is beneficial or detrimental is far from consensus among researchers. Moreover, previous literature mostly concentrated on the seismic behaviour of mid-rise buildings and moment-resisting frames. Therefore, it is in real need to comprehensively investigate the seismic response of tall buildings considering SSI. In this study, a soil-foundation-structure model developed in finite element software and verified by shaking table tests is used to critically explore the effects of SSI on high-rise buildings with a series of superstructure and substructure parameters. The beneficial and detrimental impacts of SSI are identified and discussed. Numerical simulation results indicate the rise in the stiffness of subsoil can dramatically amplify the base shear of structures. As the foundation rotation increases, inter-storey drifts are increased, and base shears are reduced. In general, SSI amplifies the inter-storey drifts showing detrimental effects of SSI. However, as for the base shear, SSI exerts detrimental effects on most piled foundation cases as well as classical compensated foundation structures resting on Ce soil, whereas, for compensated foundation structures resting on soil types De and Ee, effects of SSI are beneficial since the base shear is reduced. Moreover, regarding buildings with different structural systems and foundation types, minimum base shear ratios considering the SSI reduction effect are presented.