The changes in pore structure within soil-rock mixtures under freeze-thaw cycles in cold regions result in strength deterioration, leading to instability and slope failure. However, the existing studies mainly provided qualitative analysis of the changes in pore or strength of soil-rock mixture under freeze-thaw cycles. In contrast, few studies focused on the quantitative evaluation of pore change and the relationship between the freeze-thaw strength deterioration and pore change of soil-rock mixture. This study aims to explore the correlation between the micro-pore evolution characteristics and macro-mechanics of a soil-rock mixture after frequent freeze-thaw cycles during the construction and subsequent operation in a permafrost region. The pore characteristics of remolded soil samples with different rock contents (i.e., 25%, 35%, 45%, and 55%) subjected to various freeze-thaw cycles (i.e., 0, 1, 3, 6, and 10) were quantitatively analyzed using nuclear magnetic resonance (NMR). Shear tests of soil-rock samples under different normal pressures were carried out simultaneously to explore the correlation between the soil strength changes and pore characteristics. The results indicate that with an increase in the number of freeze-thaw cycles, the cohesion of the soil-rock mixture generally decreases first, then increases, and finally decreases; however, the internal friction angle shows no apparent change. With the increase in rock content, the peak shear strength of the soil-rock mixture rises first and then decreases and peaks when the rock content is at 45%. When the rock content remains constant, as the number of freeze-thaw cycles rises, the shear strength of the sample reaches its peak after three freeze-thaw cycles. Studies have shown that with an increase in freeze-thaw cycles, the medium and large pores develop rapidly, especially for pores with a size of 0.2–20 μm. Freeze-thaw cycling affects the internal pores of the soil-rock mixture by altering its skeleton and, therefore, impacts its macro-mechanical characteristics.