Permanent ground displacement (PGD) caused by surface faulting is considered as one of the most significant hazards affecting buried pipelines. Pipelines crossing reverse-slip faults are subjected to compressive actions (stresses and strains) which can result in buckling of the pipe. In current work, the results obtained from the full-scale laboratory testing and finite element analyses of 4″ (114.3mm) and 6″ (168.3mm) steel gas pipes (without internal pressure) buried inside a split box and subjected to a reverse faulting of 0.6m (pure dip-slip) are presented. These pipes are commonly used in gas distribution lines and networks. The experimental setup, procedure and instrumentation as well as the finite element (FE) modeling of the problem are described in detail. It is observed that the soil failure in the moving part of the split-box occurs along vertical surfaces extending from the sides of the pipe to the ground surface. The experimental results indicate that both pipes exhibit an S-shape deformation with two local buckling sections where the excessive yielding and plastic deformations of the pipes could lead to rupture failure. Both pipes exhibited “diamond-shape” buckled sections. The buckled sections of the pipes in the fixed and moving parts of the split box were unsymmetrical with respect to the fault plane. Using the factor of ovality to measure the pipe cross-section distortion, it is found that the cross-section distortion is more severe for the buckled section of the pipe in the moving part of the split box in comparison to its fixed part. Also, the distance between the buckled sections increases by increasing the pipe diameter, while the distortion of the pipe cross-section increases by increasing the pipe diameter over thickness ratio. Using the FE models that were validated utilizing the experimental results, the maximum equivalent soil–pipe interaction forces and their distribution along the pipes were determined and the results were compared with that of American Lifeline Alliance Guidelines for the Design of Buried Steel Pipe (ALA, 2005) [33]. The obtained maximum bearing force is less than the suggested values by ALA, while the maximum uplift force slightly exceeds those of ALA. The results indicate that for the considered cases, the uplift force is sensitive to the pipe diameter and its relative stiffness, while the ALA (2005, [33]) suggests a constant force for the burial depths considered in this study.