Soilless production of vegetables is rapidly gaining momentum and popularity especially in the periurban agricultural space. But this requires suitable technological backstopping in terms of substrate, nutrientmanagement and irrigation scheduling. Open and polyhouse experiments were conducted to study the effect ofvarying levels of N, P and K on the growth, biomass, yield and nutritional quality of zucchini hybrid ‘Champion’under soilless culture. The study was carried out with four different NPK levels and seven replications in acompletely randomized design. The results revealed that the nutrient scheduling of 168 ppm N-NO3, 16 ppm Pand 189 ppm K recorded maximum fruit length (24.12cm), fruit girth (44.4mm), fruit weight (335.6g) and yieldper plant (5.71 kg) and per hectare (71.39 tonnes) under open-field soilless culture. However, maximum plantheight (61.25cm), number of leaves (43.33) and total plant dry biomass (146.8g/plant) of zucchini were recordedwith application of 185 ppm N-NO3, 19 ppm P and 224 ppm K. Between open and polyhouse soilless cultivationof zucchini, highest plant height (80.6cm), number of leaves (47.4), number of fruits (22.3) and total plant drybiomass (184.7g/plant) were recorded with polyhouse conditions. Nevertheless, the highest stem diameter(35.2mm), maximum fruit length (23.2cm), maximum fruit girth (42.9mm), fruit weight (315.4g) and yield per plant(5.27kg) and per hectare (65.8t/ha) were recorded with open-field soilless culture. Zucchini plants raised on Arka Fermented Cocopeat registered higher plant height (54.7cm), stem diameter (35.2mm), number of leaves (39.3),total plant dry biomass (139.8g/plant), number of fruits (16.8), fruit length (23.2cm), fruit girth (42.9mm), fruitweight (315.4g) and yield (5.27kg/plant and 65.8t/ha) compared to soil (3.70 kg/plant and 46.3t/ha). The resultsestablished that the growers can increase zucchini yield and fruit quality and advance fruit production (10 days)by changing from soil to soilless culture.