Tuberculosis is a severe and life-threatening illness that affects numerous individuals worldwide every day. The key objective of this study was to create a system that could enhance the monitoring and management of tuberculosis patients. To achieve this goal, the Mobile D methodology was utilized because of its effectiveness in project management. This methodology emphasizes test-driven development, continuous integration, and optimization to enhance software processes. The outcome of this research was a prototype of a mobile application specifically designed for individuals with tuberculosis. Professionals and people affected by the disease assessed the quality of the prototype. They evaluated its effectiveness, user-friendliness, design, and functionality and gave ratings of 4.77 and 4.69 on a Likert scale, respectively. These figures indicate that the prototype meets high-quality criteria. In conclusion, this research successfully created an efficient prototype that enhances the monitoring and control of tuberculosis patients. The prototype includes features such as real-time consultations for immediate interaction between physicians and patients, clinical history visualization, and medication reminders, all of which improve the user’s experience.