We recently encountered pneumomediastinum and soft-tissue emphysema occurring during pneumoencephalography in 5 children. Because this complication is not described in several textbooks of neuroradiology (1, 4), these cases will be described, and possible mechanisms for the development of pneumomediastinum following pneumoencephalography discussed. Case Material Initially, air in the retropharyngeal soft tissues was observed during pneumoencephalography in 2 patients (Fig. 1), and pneumomediastinum was confirmed on radiographs of the chest. Subsequently, chest roentgenograms were obtained on all children in whom pneumoencephalography was performed. Pneumomediastinum as well as air in the retropharyngeal space was soon found in a third child. Radiographs of the lumbar spine were obtained in 2 of these 3 patients but no air was noted in soft tissues about it in either instance (Fig. 2). Following the recognition of this finding, the authors reviewed 79 consecutive pneumoencephalography studies performed over the previous four years at the University of Arkansas Medical Center. Air in the retropharyngeal soft tissues was found in 2 additional children. This finding was presumed indicative of pneumomediastinum, although radiographs of the chest were not available for confirmation. In this institution, lumbar pneumoencephalography is performed with the patient in a flexed position, either recumbent or sitting upright, with the chin and knees touching. Only minimal sedation is used. The indications for the examination were mental retardation in 3 patients, diabetes insipidus in 1, and cranial enlargement in 1. In 4 of the 5 patients in whom pneumomediastinum developed during pneumoencephalography, air was present in either the cerebral subarachnoid space or the ventricular space. In the fifth patient, air was noted in the spinal subarachnoid space when the pneumomediastinum was recognized, and the procedure was terminated. The patients in whom pneumomediastinum developed ranged in age from seven days to four years, only 1 being more than one year old. The total incidence of this pneumoencephalography complication in children under five years of age was 10 per cent. No complications developed from the pneumomediastinum in any case. Air in the soft tissues of the neck and axillae was noted twenty-four hours after the pneumoencephalogram in 2 patients, but this cleared spontaneously. Discussion The most immediately obvious explanation for a pneumomediastinum following pneumoencephalography is that the air injected reached the mediastinum by some devious route. A fascial space does exist by which air could pass from the region of the lumbar spine to the mediastinum (2). It extends from the base of the skull to the tip of the coccyx and is bounded anteriorly by the prevertebral fascia and posteriorly by the anterior surfaces of the vertebral bodies. Laterally this space extends to the tips of the transverse processes.
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