BackgroundThe aim of this study was to cephalometrically evaluate and compare a treatment protocol in patients with Class II Division 1 (II/1) and Class II Division 2 (II/2), and to pursue predictors of the change in chin prominence. MethodsThis retrospective study included 30 patients with Class II/1 and 25 patients with Class II/2 treated with the Forsus appliance, in combination with fixed appliances. Pre- and posttreatment lateral cephalometric radiographs were collected, and 28 measurements were recorded. A two-sample t test was used for the pretreatment comparison among the two Divisions. Paired t tests were used to evaluate the treatment changes within each group. Analysis of covariance was used to compare the treatment changes between the Divisions after adjusting for the baseline value, age, gender, treatment duration, and time with the Forsus appliance. The Simes multiple testing procedure permitted adjustment for multiple comparisons. Regression analysis was performed to identify predictors explaining the change in chin prominence. ResultsClass II correction occurred in both Divisions, mainly through dentoalveolar effects. There were no significant cephalometric differences found in the mean treatment changes between the Divisions. The pretreatment Gonial angle, molar eruption, lower incisor inclination, mandibular body length, and soft tissue chin thickness had a significant impact on the treatment changes in chin prominence. ConclusionsTreatment with the Forsus in combination with preadjusted fixed appliances leads to a favorable treatment outcome and produces similar treatment changes in both Class II Divisions.