Soft Template Method Research Articles

Mesoporous materials 2.0: innovations in metals and chalcogenides for future applications

Abstract Incorporating mesoporous structures into various materials can provide abundant active sites and facilitate smooth diffusion, and their effectiveness has been demonstrated across a range of material types. However, despite the development of numerous mesoporous materials, first-generation mesoporous materials (e.g., silica-based compositions) have limited applications due to their poor electrical conductivity and limited compositional diversity, necessitating additional processing for widespread utilization. Our group first proposed the synthesis of mesoporous metals using a solution-based soft-templating method based on self-assembly of micelles, marking a significant advancement in mesoporous materials. This effective process has recently been extended to the synthesis of mesoporous metals and chalcogenides. Chalcogenides have garnered significant attention due to their intriguing optical, electrical, and electrochemical properties arising from their distinctive electronic structures. Mesoporous chalcogenides have been found to effectively enhance these properties. This paper provides a comprehensive review of the synthesis of mesoporous metals and chalcogenides—representing second-generation mesoporous materials (mesoporous materials 2.0)—with specific examples. Our goal is to inform readers about second-generation mesoporous materials and provide insights for further research.

Engineering Porous Poly-Ionic Liquid via a Soft Template Approach: Novel Carrier for Robust Incorporation of Phosphomolybdic Acid for Oxidative Desulfurization

Porous polyanionic liquids (PIL) were constructed via a soft template method. Phosphomolybdic acid (PMA) anions were uniformly loaded into the pores by ion exchange. Various characterizations of the synthesized catalysts...

Processes of Obtaining Nanostructured Materialswith a Hierarchical Porous Structure on the Example of Alginate Aerogels.

Currently, materials with specific, strictly defined functional properties are becoming increasingly important. A promising strategy for achieving these properties involves developing methods that facilitate the formation of hierarchical porous materials that combine micro-, meso-, and macropores in their structure. Macropores facilitate effective mass transfer of substances to the meso- and micropores, where further adsorption or reaction processes can occur. Aerogels represent a promising class of materials for implementing this approach. The formation of hierarchical porous structures in aerogels can be achieved using soft and hard templating methods or by foaming techniques. This paper presents a comprehensive study of three methods for forming hierarchical porous structures in alginate aerogels: (1) employing surfactants (Pluronic F-68), (2) using zein as a pore-forming component, and (3) foaming in a carbon dioxide medium. The results of micro-CT showed that each of the methods contributes to the formation of macropores within the structure of the resulting aerogels. Size distribution curves of the detected macropores were obtained, showing the presence of macropores ranging from 16 to 323 μm in size for samples obtained using surfactants, from 5 to 195 μm for samples obtained using zein, and from 20 μm to 3 mm for samples obtained by foaming in a carbon dioxide medium. The SEM images demonstrated the macro- and mesoporous fibrous structure of the obtained materials. The nitrogen porosimetry results indicated that samples obtained using surfactants and zein are characterized by a high specific surface area (592-673 m2/g), comparable to the specific surface area for an alginate-based aerogel obtained without the use of pore-forming components. However, the use of the developed methods for the formation of a hierarchical porous structure contributes to an increase in the specific mesopores volume (up to 17.7 cm3/g). The materials obtained by foaming in a carbon dioxide medium are characterized by lower specific surface areas (112-239 m2/g) and specific mesopores volumes (0.6-2.1 cm3/g). Thus, this paper presents a set of methods for forming hierarchical porous structures that can obtain delivery systems for active substances with a controlled release profile and highly efficient platforms for cell culturing.

Mesoporous Carbon Composites Containing Carbon Nanostructures: Recent Advances in Synthesis and Applications in Electrochemistry.

Carbon nanostructures (CNs) are various low-dimensional allotropes of carbon that have attracted much scientific attention due to their interesting physicochemical properties. It was quickly discovered that the properties of CNs can be significantly improved by modifying their surface or synthesizing composites containing CNs. Composites combine two or more materials to create a final material with enhanced properties compared with their initial components. In this review, we focused on one group of carbon materials-composites containing CNs (carbon/CN composites), characterized by high mesoporosity. Particular attention was paid to the type of synthesis used, divided into hard- and soft-templating methods, the type of polymer matrix precursors and their preparation method, heteroatom doping, pore formation methods, and correlations between the applied experimental conditions of synthesis and the structural properties of the composite materials obtained. In the last part, we present an updated summary of the applications of mesoporous composites in energy storage systems, supercapacitors, electrocatalysis, etc. The correlations among porous structures of materials, heteroatom doping, and electrochemical or catalytic efficiency, including activity, selectivity, and stability, were also emphasized. To our knowledge, a single review has never summarized pyrolyzed mesoporous composites of polymer-CNs, their properties and applications in electrochemistry.

UV Irradiation as a Versatile Low-Temperature Strategy for Fabricating Templated Mesoporous Titania Films.

Mesoporous titania thin films offer promising applications in sensors, batteries, and solar cells. The traditional soft templating methods rely on high-temperature calcination, which is energy-intensive, incompatible with thermosensitive flexible substrates, and destructive for titania structures. This work demonstrates UV irradiation as a versatile low-temperature and energy-saving alternative for mesoporous crystalline titania fabrication. Grazing incidence wide-angle X-ray scattering analysis reveals a three-stage crystallization process with increasing UV irradiation time supported by photoluminescence data. UV-irradiation-derived samples exhibit crystallinity and crystal size comparable to that of calcination. Integration with block copolymer templated sol-gel synthesis enables the creation of various morphologies, including cylindrical, ordered spherical, and hybrid structures. Characterizations via scanning electron microscopy and grazing incidence small-angle X-ray scattering confirm the homogeneity of morphology in the resulting films. The resulting films maintain similar optical properties despite morphological differences, as demonstrated by photoluminescence and UV-vis measurements. The versatility of UV irradiation extends to different titanium precursors, underscoring it as a flexible and efficient method for mesoporous titania thin film fabrication at low temperatures.

Highly Ordered Bimodal Mesoporous Carbon from ABC Triblock Terpolymers with Phenolic Resol.

Mesoporous carbons (MPCs) with a bimodal distribution of pore diameters are more advantageous than their monomodal counterparts for applications in adsorption, catalysis, and drug delivery systems; however, reports on their fabrication remain limited. In this study, we successfully fabricated bimodal MPCs using a soft template method with poly(2,2,2-trifluoroethyl methacrylate) (PTFEMA)-b-poly(4-vinylpyridine) (P4VP)-b-polystyrene (PS) and resol. The blend samples formed microphase-separated structures comprising PTFEMA spheres, PS cylinders, and matrix domains composed of P4VP and resol, leading to the separation of the PTFEMA and PS domains. The P4VP and resol matrix domains were carbonized at a high temperature of 900 °C, whereas the PTFEMA and PS domains were thermally decomposed. This process resulted in bimodal MPCs with both spherical and cylindrical mesopores. The pore diameters calculated using scanning electron microscopy were approximately 10 and 30 nm, while nitrogen adsorption measurements indicated a large specific surface area with a bimodal pore distribution.

Efficiently Designed Three-Dimensional Architecture of CoMn2O4 Decorated V2CTx MXene for Asymmetric Supercapacitors.

The structure, morphology, stoichiometry, and chemical characterization of the V2CTx MXene, CoMn2O4, and V2C@CoMn2O4 nanocomposite, prepared by using a soft template method, have been studied. The electron microscopy studies reveal that the V2C@CoMn2O4 composite incorporates mesoporous spheres of CoMn2O4 within the 2D layered structure of MXene. The specific capacitance of the composite electrode is ∼570 F g-1 at 1 A g-1, which is significantly higher than that of the sum of the individual components. It also exhibits great rate capability and a Coulombic efficiency of ∼96.5% over 10000 cycles. An asymmetric supercapacitor prototype created with V2C@CoMn2O4//activated carbon outperformed other reported ASCs in terms of achieving a high energy density of 62 Wh kg-1 at a power density of 440 W kg-1. The improved response of V2C@CoMn2O4 and ASC is attributed to the enhanced active area available for charge transfer and the synergistic interaction between CoMn2O4 spherical particles and nanolayered MXene. Supporting density functional theory (DFT) calculations are performed to understand the impact of composite heterojunction formation on its detailed electronic structure. Our atomistic simulations reveal that by incorporating CoMn2O4 in V2C, the density of electronic states at the Fermi level increases, boosting the charge transfer characteristics. These modifications in turn enhance the charge storage capabilities of heterojunction. Finally, the merits of the V2C@CoMn2O4 composite electrode are discussed by comparing it with those of other existing high-performance MXene-based composite electrodes.

Nitrogen-Doped Mesoporous Carbons Fabricated from Self-Assembled Block Copolymers for Electrochemical Production of H2O2

Nitrogen-doped mesoporous carbons are attracting significant attention as next-generation electrocatalytic materials due to their high specific surface area, high electrical conductivity, and exceptional chemical stability. Especially, due to the facilitated mass transport of products, high selectivity for the two-electron oxygen reduction reaction is expected, making it applicable to the synthesis of hydrogen peroxide (H2O2).¹ In this study, we focused on the soft template method by utilizing the self-assembly of a block copolymer (BCP) through microphase separation.² In our laboratory, we have been working on the synthesis of poly(4-vinylpyridine)-b-poly(2,2,2-trifluoroethyl methacrylate) (P4VP-b-PTFEMA). The significant repulsive interaction between these two components allows extensive control of the domain size. Furthermore, poly(4-vinylpyridine) serves as both the nitrogen and carbon sources and is selectively crosslinked by resol, thus enabling a high carbonization yield to be obtained. We employed this BCP as a soft template and introduce resol as a cross-linker for fabricating nitrogen-doped mesoporous carbons. Here, we investigated in detail the effects of the composition of the block copolymer and the amount of the crosslinker on the morphology and nitrogen content of the mesoporous carbon.P4VP-b-PTFEMA was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. A mixture of P4VP-b-PTFEMA and resol was dissolved in DMF at 5 wt%, and the solution was evaporated and dried under vacuum at 100 °C for 24 hours to prepare a composite film. Subsequently, the film was heated to 900 °C to fabricate nitrogen-doped mesoporous carbons.Small-angle X-ray scattering (SAXS) analysis of the composite film revealed various microphase-separated structures depending on the BCP-to-resol ratio (Fig. 1 (a)). Furthermore, nitrogen-doped mesoporous carbons with pore diameters ranging from 6.2 nm to 24 nm were fabricated using various molecular weights of PTFEMA (Fig. 1 (b)). Additionally, in our presentation, we will discuss how the pore size affects the selectivity of the two-electron reaction and the catalytic efficiency in the oxygen reduction reaction.[Reference](1) Park et al., ACS Catal. 2014, 4, 3749.(2) Liu et al., Polym. Chem. 2014, 5, 6452.[Acknowledgement]This study was financially supported by JSPS-KAKENHI(21K04828). Figure 1

(Invited) Optimizing the Activity of Oxygen Reduction Reaction Via Structural Engineering of Support for Fe-N-C Electrocatalysts in Proton Exchange Membrane Fuel Cells

The scarcity and costliness of platinum group metals in PEMFC cathodes hinder commercialization. Despite the promise of Fe-N-Cs electrocatalysts as alternatives, their oxygen reduction reaction (ORR) performance falls short. To address this, two carbon support-structural engineering methods were devised. Firstly, defect adjustment in ZIF-NC carbon support, derived from zeolitic imidazolate frameworks, via CO2 activation. Secondly, introduction of mesopores into ZIF-NC using the block co-polymer soft-template method. Controlled degree of defect sites in supports enhance intrinsic activity of Fe-N4 by modifying electronic structure such as charge distribution and spin state. Mesopores aid mass transport, improving active site accessibility. Additionally, the curved surfaces and carbon edge sites generated by mesopores alter the geometric structure of Fe-N4, optimizing the adsorption energy of oxygen species. Support-structural engineered Fe-N-Cs electrocatalysts exhibit relatively outstanding ORR performance compared to pristine Fe-N-C. MEAs with these electrocatalysts exhibit impressive peak power densities, highlighting their high activity at the MEA level.

Electrochemically Deposited Nanoarchitectured Nanoporous Metal Film Using Block Copolymer Micelle for Ultra-Sensitive SERS Platform

Utilizing surface-enhanced Raman scattering (SERS) substrates with plasmonic metals is a rapid, convenient, and powerful spectroscopic technique for molecule detection. The performance of SERS, including the limit of detection (LOD) and enhancement factor (EF), relies on the SERS substrate. These substrates contain plasmonic nanostructures, and the formation of nanogaps between them is one of the crucial factors. Therefore, the development of nanomaterials and nanostructures plays a pivotal role in creating high-performance SERS substrates. Despite numerous studies, achieving rich nanogap formation and establishing reliable processes remain challenging tasks. Firstly, we introduce a novel nanoarchitecture technique utilizing nanoporous metal films and nanoparticles to create abundant nanogaps. We fabricated a new type of SERS substrate with plasmonic nanoporous Au films using a soft-templating method combined with electrochemical deposition. Through precise surface modification and control of surface charge, we achieved well-defined nanogaps. Additionally, we present a new nanoarchitecture technique for forming hotspots by adjusting the gaps between nanoporous plasmonic Au pattern films. By adjusting the deposition voltage and time, we controlled the gaps between the patterns. The nanopatterns and nanoporous structures exhibit strong light trapping ability, owing to multiple reflections of light in the pore, and they possess a larger specific surface area, which enhances the enrichment of target molecules, leading to the formation of more "hot spots" and the enhancement of LSPR effect. Moreover, the multiple electric field couplings of the nanopatterns and nanoporous structures further enhance the local electromagnetic field. In conclusion, 3D SERS sensors hold great potential for revolutionizing various fields such as environmental monitoring, medical diagnostics, and chemical analysis. These products feature ultra-high sensitivity, high spatial resolution, and customizable design, making them indispensable tools for detecting and analyzing molecules at low concentrations. The advancements in substrate fabrication bring us one step closer to maximizing their potential, and continuous research and development will undoubtedly transform approaches to molecular analysis. This presentation emphasizes the importance of utilizing reliable nanomaterials and nanoarchitecture techniques for nanogap formation. Figure 1

Green preparation of high-efficiency mesoporous MoP electrocatalyst for hydrogen evolution

The production of hydrogen generation catalysts through inexpensive, green and sustainable route is urgently needed in the context of “double carbon”. In this work, a new mesoporous transition metal phosphide (P–MoP@C) as electrocatalytic hydrogen evolution catalyst was prepared by a soft template method using polyoxometalate (POM), biomass gallic acid and ammonium polyphosphate through one-step phosphating and calcination process. The mesoporous structure is formed by organic-organic self-assembly strategy facilitated by strong hydrogen bonding between the pyrogallol group on gallic acid and the block copolymer. P–MoP@C shows good catalytic and stability properties, with overpotentials of 149 and 162 mV in alkaline and acidic solutions, respectively, at a current density of 10 mA cm−2. The mesoporous structure adds up to the quantity of exposed active sites, accelerates the electron transfer rate, and improves the catalytic performance of P–MoP@C. The use of plant polyphenols as a carbon source for the synthesis of green and environmentally friendly hydrogen evolution catalysts provides some reference value for large-scale industrial production.

Hollow hydrangea-like Mo2C/MoO2/C composites with tunable phase compositions as highly efficient microwave absorbers

With the advancement of modern electronic communication technology, the development of efficient absorbing materials has attracted great interest. Here, hollow hydrangea-like Mo2C/MoO2/C composites are synthesized by soft template method. By adjusting the pyrolysis temperature, Mo2C/MoO2/C composites with different Mo2C and MoO2 contents and degrees of graphitization can be selectively synthesized. The Mo2C/MoO2/C-800 composite with the 30 wt% filler content exhibits a minimum reflection loss of −62.9 dB at 1.6 mm and achieves a maximum absorption bandwidth of 6.2 GHz at 1.9 mm. The interaction between the dielectric properties of each component and the unique 3D hydrangea-like structure promotes microwave absorption and dissipation. Besides, CST simulation further demonstrates the effectiveness of electromagnetic wave dissipation in practical applications. The excellent properties of the hydrangea-like Mo2C/MoO2/C composites indicate their promising applications in electromagnetic wave absorbers.

Wear and corrosion resistance of textured and functionally particle-enhanced multilayer dual-biomimetic polymer coatings

This study presents a dual-biomimetic polymer coating with improved wear and corrosion resistance, inspired by natural biological structures of shells and superhydrophobic surfaces. The coating is composed of alternating hard epoxy resin layers, modified with benzotriazole-functionalized silica for corrosion protection, and soft fluorocarbon resin layers, enhanced with graphene oxide for improved mechanical properties. Surface textures were added using a soft template method to boost hydrophobicity and reduce wear. The coating demonstrated excellent hardness, impact resistance, and corrosion protection, particularly in simulated seawater. Additionally, surface textures further minimized wear by trapping debris. This design strategy offers a promising approach for advanced polymer coatings in marine, machinery, and chemical applications, combining durability, protection, and self-healing properties.

Efficient remediation of cadmium and lead contaminated soil in coal mining areas by MICP application in hydrothermal carbon-based bacterial agents: Nucleation pathways and mineralization mechanisms

The development of industrial mining has resulted in a large amount of Cd and Pb polluting the soil in mining areas, and leads to adverse health effects on the life of both plants and animals. Here, a soft template method was conducted to prepare hydrothermal carbon (HC) with regular morphology, which assisted with Bacillus pasteurii to induce calcite precipitation for decontamination of mining soil. Soil remediation experiments over 30 days of remediation with an HC microbial agent (HCMA) resulted in 89.4% and 87.8% decrease in the amount of leached Cd and Pb, respectively. The content of exchangeable Cd and Pb decreased by 76.1% and 81.0%, respectively. At the same time, soil fertility significantly improved. The electrostatic potential and surface charge distribution of extracellular polymeric substances (EPS) and sodium citrate (NaCit) were analyzed using DFT simulations, their nucleophilic and electrophilic regions were determined, and the nucleation mechanism was determined. The DFT results indicated that the oxygen-containing groups of EPS and NaCit had strong negative electrostatic potential and electronegativity, which could cause Cd2+, Pb2+, and Ca2+ to aggregate on their surfaces. They also combined with CO32− produced by urease during the decomposition of urea, resulting in Cd2+ and Pb2+ being encapsulated by calcium carbonate to form a coprecipitate. X-ray diffraction analyses revealed that the precipitate was mainly calcite calcium carbonate, which is more stable and less prone to secondary leaching of HMs. The gathered data prove the significant role of HCMA in remediation of mining soil contaminated with Cd and Pb.

Mechanistic Insights into the Removal of Surfactant-Like Contaminants on Mesoporous Polydopamine Nanospheres from Complex Wastewater Matrices.

The detrimental environmental effects of surfactant-like contaminants (SLCs) with distinctive amphiphilic structures have garnered significant attention, particularly since perfluorooctanesulfonate was classified as a persistent organic pollutant. Despite the numerous absorbents developed for SLCs removal, the underlying interaction mechanisms remain speculative and lack experimental validation. To address this research gap, we elucidate the mechanistic insights into the selective removal of SLCs using mesoporous polydopamine nanospheres (MPDA) fabricated via a novel soft-template method. We employed low-field nuclear magnetic resonance to quantitatively characterize the hydrophilicity of the absorbents using water molecules as probes. The results demonstrated that MPDA with uniform mesopores exhibited a remarkable threefold enhancement in SLCs' adsorption capacity compared to conventional polydopamine particles via intraparticle diffusion. We further demonstrated the dominant effects of electrostatic and hydrophobic interactions on the selective removal of SLCs with MPDA by regulating the isoelectric pH value and performing a comparative analysis. The mechanism-inspired SLC-removal strategy achieved an average removal rate of 76.3% from highly contaminated wastewater. Our findings offer new avenues for applying MPDA as an efficient adsorbent and provide innovative and mechanistic insights for targeted SLC removal in complex wastewater matrices.

N vacancies and OH/C=O co-modified g-C3N4 photoactivated peroxymonosulfate for the degradation of tetracycline: Synergistic promotion effect between excitons and carriers

Activation of peroxymonosulfate (PMS) to generate reactive oxygen species (ROS) for pollutant degradation via metal-free photocatalysts is an important green wastewater treatment and remediation method, but the pathway for generating ROS via exciton effects in catalysts is often overlooked. In this study, OH/C=O co-modified N-defective rod-shaped carbon nitride (Nv-CN-O) was designed and synthesized by soft template and alkali hydrothermal method. In the Nv-CN-O/PMS/Light system, there was a synergistic degradation of tetracycline (TC) by carriers and excitons, with a degradation rate 2.15 times higher than that of CN/PMS/Light. N vacancies and OH/C=O enhanced the adsorption to PMS, accelerated the charge transfer process, and activated PMS to generate ·O2− dominated reactive species. The functional group OH/C=O promoted the production of triplet excitons that through the energy transfer pathway to promote the production of 1O2. Abundant ROS were involved in the TC degradation process, and three possible TC degradation pathways were proposed. Nv-CN-O has strong anti-interference ability in actual water bodies, shows a promoting effect on the degradation of TC, which has practical application potential.

Synthesis of mesoporous niobium phosphosilicate with high catalytic activity in the conversion of glucose to 5‐hydroxymethylfurfural in water solvent

AbstractMesoporous niobium‐based solid acid catalysts were successfully synthesized using the soft template method with sodium lignosulfonate (SLS) as the template. In most studies the template is calcined to form mesopores after hydrothermal synthesis; however, in this study SLS was retained to produce niobium‐carbon composite catalysts. The catalysts obtained were characterized by X‐ray diffraction, nitrogen adsorption–desorption, Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis, and static contact angle measurements. The catalytic activity of the solids was also investigated in the conversion of glucose to 5‐hydroxymethylfurfural (HMF) using pure water as the solvent. Under optimal conditions, niobium‐carbon composite catalyst achieved a glucose conversion yield of 65.1% and an HMF yield of 42.1%. The enhanced catalytic activity was attributed to the timely extraction of the HMF by the carbonized SLS.

Biologically inspired shell-hollow particles for designing efficient passive all-sky radiative cooling

Passive radiation cooling (PRC), as the most promising technology to meet future cooling needs, has attracted great interest. However, there are still huge challenges in manufacturing high-efficiency and low-cost radiant coolers suitable for all-day use. Here, we report a secondary micro-nano shell-hollow structure based on blending method, inspired by the African white beetle Goliathus goliatus. Due to the difference in reflectance between the shell and the internal air, compared with the homogeneous particles, the scattered light has a changed optical path at the interface of the core (air) and the shell (SiO2), and most of the light escapes from the particles, showing strong total internal reflection. The design ingeniously deposits the nano-sized shell-hollow structure on the surface of the micron-sized shell-hollow structure, achieving high solar reflectance (95 ​%)and excellent long-wave infrared emissivity (94 ​%). Sub-ambient cooling of 7.8 and 4.7 ​°C can be achieved at night and daytime, respectively. Silica microspheres with shell and hollow structure can be prepared by soft template method, which is mature, reliable, simple and cheap.Our work provides new ideas for the design and manufacture of high-performance Passive all-day radiative cooling (PARC).

Synthesis of an ion-imprinted starch phosphate porous carbonaceous material removing U(VI) from wastewater: Kinetics and mechanism

Uranium enrichment and separation are important for the sustainable development of nuclear energy. In this study, reverse-phase emulsion crosslinking polymerization was used to synthesize spherical hollow porous carbon materials (II-CLSPC) with a “red blood cell” morphology after roasting. The soft template method was used to modify II-CLSPC to obtain an open pore structure, which increased its contact area. Based on this, ion imprinting was conducted to improve the selective adsorption of U(VI). A spatial site matching the size of U(VI) was formed after ion template removal, which played a crucial role in this process. Multifaceted and multilevel improvements of II-CLSPC facilitated rapid adsorption, reaching equilibrium at 40 min and a removal rate of 94.6 % (pH 5, 298 K). The pseudo-second-order kinetic model and Langmuir isothermal model indicated that the adsorption process of uranyl ions by II-CLSPC involved via monolayer chemisorption with a theoretical saturation adsorption capacity of 653.6 mg g−1. In addition, II-CLSPC exhibited excellent selectivity (KdU = 3.7 × 104 mL g−1), cyclic stability, and salt tolerance, making it a promising candidate for uranium removal from wastewater.

Synthesis and application of mesoporous MIL-88A for enhanced lipase immobilization and high value oil conversion

MIL-88A, a metal–organic framework (MOF), has significant promise for lipase immobilization due to its robust acid and water tolerance coupled with cost-effectiveness. Nonetheless, enhancing the dimensional compatibility of carrier with lipase and substrate is imperative for its broader application. In this study, we innovatively synthesized mesoporous MIL-88A (Meso-MIL-88A) with a fairly wide pore distribution around 10 nm using a soft-template method followed by a citrate dissociation strategy. The adsorption isotherm of Meso-MIL-88A conformed to the Langmuir model, exhibiting a notable increase in the adsorption capacity of lipase ET 2.0 compared to common MIL-88A (C-MIL-88A), attributed to the augmented external specific surface area (59 to 19 m2/g). Moreover, the immobilized lipase on Meso-MIL-88A showcased superior specific activity and enzyme activity recovery in contrast to C-MIL-88A, owing to enhanced structural preservation of lipase protein and reduced mass transfer resistance. Greater stability towards pH and temperature and better dynamic performance of immobilized lipase compared to free lipases exhibited the great advantages of Meso-MIL-88A as immobilized carrier. Notably, in the synthesis of phosphatidyl DHA (docosahexaenoic acid), immobilized CalB (Candida antarctica lipase B) on Meso-MIL-88A exhibited a 41.89 % incorporation of DHA into PC (phosphatidylcholine) within 48 h and an 82.60 % recovery after five batches of use. SEM observations confirmed the sustained integrity of the immobilized lipase structure post-recycling, underscoring the good stability of Meso-MIL-88A in the catalysis system. This study unveils the substantial potential of Meso-MIL-88A in lipase immobilization and offers a facile approach to tailoring the pore size of MOFs for practical application system.