Objective To compare the effects of sodium potassium magnesium calcium and Glucose Injection, 5% Glucose Injection and 9% Sodium Chloride Injection on children with blood glucose, blood lactic acid and blood gas electrolyte during operation on children. Methods patients were randomly divided into A group(sodium potassium magnesium calcium and Glucose Injection group,n=20), B group(5% sodium chloride glucose injection, n=20)and C group(9% Sodium Chloride Injection group, n=20). Blood glucose, blood lactic acid, arterial blood Gas and electrolytes were measured and compared before infusion (T0)and on postoperative time(T1). Results blood glucose in B group increased but decreased significantly in C group(P < 0.05).;Blood lactic acid in C group significantly decreased than the other two groups(P < 0.05); Mg2+ decreased in B and C groups(P < 0.05). Conclusion Sodium Potassium Magnesium Calcium and Glucose Injection has the same efficacy and safety as commonly used 5% sodium chloride glucose injection and 9% sodium chloride injection, when infused in pediatric patients during perioperative period.