There is a phenomenal increase in the number of cases of women suffering from mental illness in our contemporary society, which is hard hit by pandemics. As scholarship reflects on this condition, there has been little attention paid to the impact of indigenous religion and cultural practices to the sexual and reproductive health of women with mental illness and indigenous entrepreneurs who seek economic fortunes in a post COVID-19 epoch. Largely, the Zimbabwean society detests mental illness and this has rendered mentally ill women to the social margins. However, cases of men from the mainstream society having illicit sexual intercourse with mentally ill women are rampant, both in urban and rural environments. So one can ask why men from the mainstream society are having sexual relations with the ostracised mentally ill women. Prioritizing ethical considerations, this qualitative study uses ritual theory as its theoretical framework, sociology of religion, phenomenology of religion and gendered cultural hermeneutics to explore the prevalence of these sexual practices. Data was gathered through interviews and desk research from January to December 2023. Findings of the study were that these sexual activities are ritualistic, done to enhance success in politics, business, farming and self-initiated churches. An analysis of the reasons behind the performance of these sex rituals showed that a mentally ill woman’s body is an entity which belongs to the spiritual world so the sexual relationship makes it possible for the male entrepreneur to access the spiritual world. Through these rituals, men with entrepreneurial wishes will be attempting to connect with and manipulate the spiritual world. The study concluded that mentally ill women have less choice over their sexual and reproductive lives. They are sexually exploited, yet they lack the capacity to disclose these heinous acts to the mainstream society. They are regarded by the patriarchal society as sexual preys where coercive sex and or rape are used for ritual purposes, with the intent of attaining socio-economic transformation.