The article is devoted to the research, critical rethinking and comparative characterization of the socio-economic advantages and disadvantages of calculation and analytical methods for assessing the effectiveness of innovation activities in the context of the triad “education – science – production”. The article examines the scientific, theoretical and practical-applied attributes of the “Market to Book ratio” method; algorithm for assessing goodwill using the criterion of business activity of companies; functional cost analysis; parametric assessments of technologically correlated projects (“Scorecard Methods”; methods of “Scandia Business Navigator” and company business browsers, etc.). In the process of the study, conclusions were drawn about the conceptual inconsistency and inconsistency of the proposed solutions, and the author’s calculation and analytical tools for assessing the effectiveness of innovative activities of enterprises were proposed, containing coefficients of socio-economic significance and efficiency that reproduce the priorities of sustainable innovative development.