Background and Aims: Self-care is crucial for the elderly since it allows everyone to have a healthy life, boost immunity, prevent sickness, care for themselves when unwell, and continue to perform everyday duties in their own homes. This study aimed to investigate the factors influencing the elderly's opinions on self-care in the southernmost provinces of Thailand. Methodology: This quantitative study used data collected by the Deep South Coordination Center from 271 elderly people in Pattani. The independent variable included demographic factors and health conditions. The outcome variable was a 4-point rating scale opinion on the self-care of the elderly. Descriptive statistics were employed to illustrate the sample's characteristics. Factor analysis was used to reduce the number of outcome variables. Multiple linear regression was used to examine the relationship between the outcome variables and the independent variables. Results: Eighteen outcome variables were categorized into three factors consisting of positive self-management, health preparation, and doing things for great pleasure. Elderly people who could walk with their spouse or family were more likely to have positive self-management and health preparation than those who lived alone or were separated and could not walk. Elderly people who did not engage in health-risk activities and could use public transportation independently were more likely to enjoy themselves than those who could not. Conclusion: The findings might improve the quality of self-care among the elderly to live better in their current societal situation. This can encourage care healthcare providers to promote daily living practices among the elderly.